A5101509299- Peroxisome Proliferator-Activated Receptors
- Hepatitis C virus research
- Allergic Rhinitis and Sensitization
- Cholesterol and Lipid Metabolism
- Metabolism and Genetic Disorders
- Adipose Tissue and Metabolism
- HIV/AIDS drug development and treatment
- Diet and metabolism studies
- Liver Disease Diagnosis and Treatment
- Vitamin D Research Studies
- Dermatology and Skin Diseases
- Drug Transport and Resistance Mechanisms
- Asthma and respiratory diseases
- Systemic Lupus Erythematosus Research
- Metabolism, Diabetes, and Cancer
- Immunotherapy and Immune Responses
- Respiratory viral infections research
- T-cell and B-cell Immunology
- Congenital Diaphragmatic Hernia Studies
- Mitochondrial Function and Pathology
- Glaucoma and retinal disorders
- Cancer, Lipids, and Metabolism
- Vitamin C and Antioxidants Research
- Corneal Surgery and Treatments
- Diabetes Treatment and Management
AbbVie (Germany)
2016-2021
Martin Luther University Halle-Wittenberg
2007-2020
AbbVie (United States)
2019
Research Center Borstel - Leibniz Lung Center
2011
Instituto de Ciencias Agrarias
2007
Johannes Gutenberg University Mainz
2005-2007
Kiel University
2007
Bristol Royal Hospital for Children
2005
Summary Background Glecaprevir/pibrentasvir is a pangenotypic direct‐acting antiviral regimen approved for treating adults chronically infected with hepatitis C virus (HCV). There are limited real‐world data on glecaprevir/pibrentasvir to date. Aim To evaluate the effectiveness and safety of under conditions in German Hepatitis C‐Registry (DHC‐R). Methods The DHC‐R an ongoing, non‐interventional, multicentre, prospective, observational cohort study that monitors patients chronic HCV...
In addition to its role as an essential protein component, leucine (Leu) displays several other metabolic functions such activation of synthesis. This property makes it interesting amino acid for the therapy human muscle atrophy and livestock production. However, Leu can stimulate own degradation via branched-chain keto dehydrogenase complex (BCKDH). To examine response tissues excessive Leu, pigs were fed diets containing two- (L2) four-fold (L4) higher contents than recommended amount...
Summary Background Recently, it has been established that pollen grains contain Th2‐enhancing activities besides allergens. Objective The aim of this study was to analyse whether carry additional adjuvant factors like microbes and what immunological effects they may exert. Methods Timothy were collected disseminated on agar plates, the growing microorganisms cultivated defined. Furthermore, immunologic microbial products DC T cell responses analysed. Results A complex mixture bacteria moulds...
Summary Real‐world studies are relevant to complement clinical trials on novel antiviral therapies against chronic hepatitis C; however, practice data currently limited. This study investigated effectiveness and safety of ombitasvir/paritaprevir/ritonavir ( OBV / PTV /r)±dasabuvir DSV )±ribavirin RBV ) for treatment HCV genotype GT 1 4 infection in a large real‐world cohort. The German Hepatitis C Registry is an observational cohort prospectively collecting direct‐acting therapies. Patients...
Monocarboxylates such as pyruvate, lactate and ketone bodies are crucial for energy supply of all tissues, especially during restriction. The transport monocarboxylates across the plasma membrane cells is mediated by monocarboxylate transporters (MCTs). Out 14 known mammalian MCTs, six isoforms have been functionally characterized to short chain fatty acids (MCT1-4), thyroid hormones (MCT8, -10) aromatic amino (MCT10). Knowledge on regulation different MCT rare. In an attempt get more...
Summary Regulatory CD4 + CD25 FoxP3‐positive T cells (Treg) are functional in most atopic patients with allergic rhinitis and able to inhibit helper type 1 (Th1) Th2 cytokine production of – cells. This study was designed analyse the following additional aspects: influence allergen concentration, allergen, atopy status donor on strength regulatory activity. from healthy non‐atopic controls or grass‐pollen‐allergic wasp‐venom‐allergic donors were stimulated alone presence Treg autologous...
We tested the hypothesis that transcription of novel organic cation transporters (OCTNs) is directly regulated by peroxisome proliferator-activated receptor (PPAR)-alpha. Therefore, wild-type mice and deficient in PPAR alpha (PPAR alpha-/-) were treated with agonist WY 14,643. Wild-type 14,643 had a greater abundance OCTN2 mRNA their liver, muscle, kidney, small intestine OCTN3 kidney than did untreated (P < 0.05). Moreover, abundances enzymes involved hepatic carnitine synthesis...
Recent studies have shown that dietary oxidised fats influence the lipid metabolism in rats by activation of PPARalpha. In this study, we investigated whether a mildly fat causes PPARalpha pigs which are non-proliferators like man. Eighteen were assigned to two groups and received either diet containing 90 g/kg fresh or same with an prepared heating for 24 h at 180 degrees C deep fryer. Pigs fed had higher peroxisome count, activity catalase mRNA concentration mitochondrial...
Summary Background In grass pollen‐allergic individuals, T cell anergy can be induced by IL‐10‐treated dendritic cells (IL‐10‐DC) resulting in the suppression of helper type 1 (Th1) as well Th2 cells. This study was performed to analyse whether such IL‐10‐DC‐treated are able act regulatory (Treg) suppressing function other periphery. As transforming growth factor (TGF)‐β is also a potential inducer Treg, we additionally analysed inhibitory capacity TGF‐β‐treated this system. Materials and...
Expression of peroxisome proliferator-activated receptor-α (PPARα) has been shown in liver chicks, but effects its activation have not yet investigated. In this study, laying hens were treated with clofibrate, a synthetic PPARα agonist, to investigate the on lipid metabolism. Hens receiving diet containing 5 g clofibrate/kg had lower food intake and higher mRNA concentrations typical target genes (carnitine palmitoyltransferase 1A, acyl-coenzyme A oxidase, bifunctional enzyme, lipoprotein...
To combat vitamin D insufficiency in a population, reliable diet sources of are required. The recommendations to consume more oily fish and the use UVB treated yeast already applied strategies address insufficiency. This study aimed elucidate suitability plant oils as an alternative source. Therefore, that commonly used human nutrition were firstly analyzed for their content precursors metabolites. Secondly, selected exposed short-term irradiation stimulate synthesis D. Finally, efficacy...
A case is reported in which an automatic external defibrillator (AED) was used during the successful resuscitation of a 6 year old child out-of-hospital cardiac arrest, despite fact that these devices are not recommended children under 8 years. The interpretation protocols discussed and new developments this area reported.
It has been shown that treatment of rats with clofibrate, a synthetic agonist PPARα, increases mRNA concentration organic cation transporters (OCTN)-1 and -2 carnitine in the liver. Since oxidised fats have demonstrated to activate hepatic we tested hypothesis they also up regulate OCTN. Eighteen were orally administered either sunflower-seed oil (control group) or an fat prepared by heating oil, for 6 d. Rats had higher concentrations typical PPARα target genes such as acyl-CoA oxidase,...
PPAR α is a lipid‐activable transcription factor that mediates the adaptive response to fasting. Recent data indicate an important role of brain in physiological functions. However, it has not yet been shown whether can be activated fasting state. Here we demonstrate rats increased mRNA concentrations typical target genes implicated β ‐oxidation fatty acids (acyl‐CoA oxidase, carnitine palmitoyltransferase‐1, medium chain acyl‐CoA dehydrogenase) and ketogenesis (mitochondrial...
Monocarboxylate transporter (MCT)-1 mediates the transport of ketone bodies and other monocarboxylic acids across plasma membrane. MCT1 is up-regulated by peroxisome proliferator-activated receptor (PPAR)-alpha, a transcription factor that adaptive response to fasting up-regulation genes involved in fatty acid oxidation ketogenesis. Here, we show for first time dietary natural PPAR-alpha agonists. Both, an oxidized fat conjugated linoleic increased mRNA concentration liver rats. Also, pigs...