A5082020184- Diet, Metabolism, and Disease
- Bioactive Compounds and Antitumor Agents
- Pancreatic function and diabetes
- Parasitic infections in humans and animals
- Adipose Tissue and Metabolism
- Metabolism, Diabetes, and Cancer
- Cardiac Ischemia and Reperfusion
- Nutrition, Genetics, and Disease
- Meat and Animal Product Quality
- Synthesis and Biological Evaluation
- FOXO transcription factor regulation
- Hemostasis and retained surgical items
- Urological Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- PI3K/AKT/mTOR signaling in cancer
- Diet and metabolism studies
- Synthesis and biological activity
- Birth, Development, and Health
- Connexins and lens biology
- Palliative and Oncologic Care
- Apelin-related biomedical research
- Autophagy in Disease and Therapy
- Genetic Mapping and Diversity in Plants and Animals
- Evolution and Paleontology Studies
- Congenital Ear and Nasal Anomalies
Selçuk University
2014-2024
Selçuk Üniversitesi Tıp Fakültesi Hastanesi
2012-2021
Insulin receptor substrate 1 (IRS1), plays a critical role in insulin signaling and its control has an important place the development of resistance. The tyrosine phosphorylation IRS1 serves as docking molecules for downstream effectors such Phosphatidylinositol 3-kinase phosphotyrosine phosphatase-2. We focused on Gly972Arg Ala513Pro variants gene, since these specific allelic are located near Tyr-Met-X-Met (YMXM) motifs around Tyr987 Tyr612. Thus, we aimed to investigate effects...
The phosphatidylinositol 3-kinase p85 alpha regulatory subunit 1 gene (PIK3R1) encodes the PIK3R1 protein, which plays a direct role in insulin signaling. (p85 subunit) connects firmly with p110 catalytic subunit, and together these proteins form (PI3K) protein. PI3K is key protein Akt signaling pathway, regulates cell survival, growth, differentiation, glucose trafficking, utilization. Defects cascade play an important development of resistance, shares common genetic basis for metabolic...
Abstract The Blind Mole Rats of Anatolia (Nannospalax xanthodon (Nordmann, 1840)) are characterised by prolific chromosomal diversification. While the geographic distribution various cytotypes is well documented, opinions on their taxonomic ranking varies amongst authorities. A partial sequence (630 bp) mitochondrial cytochrome b gene in 13 from Konya basin, central Anatolia, which represented three distinct (2n=40, 58, and 60) yielded nine cyt haplotypes. Phylogenetic reconstructions...
Type 2 diabetes (T2D) is1397645907a multifactorial disease, determined by environmental and genetic factors. Currently, the transcription factor 7-like (TCF7L2) gene shows strongest association with T2D. In this study, we investigated whether TCF7L2 polymorphisms are associated T2D in a Turkish population.Using PCR-RFLP PCR-SSCP, genotyped six intronic gene, commonly T2D, 169 individuals 119 healthy controls.We found that rs7903146 C → T substitution intron 3 (OR: 1.9, P = 0.005) rs12255372...
OBJECTIVES: We aimed to investigate the effects of juglone on angiogenesis, metastasis and cell proliferation processes in pancreatic cancer (PC) understand whether its possible occur via Wnt signaling pathway by analyzing expression levels target genes signaling.BACKGROUND: PC is a silent lethal type which can only be detectable after angiogenesis occured.The one pathways that plays an active role many biological cell.Mutations this are related development cancers.Juglone, natural compound,...
Background: Pancreatic cancer does not show any symptoms in the early period and metastatic process is already passed when diagnosis done. Therefore, battle with pancreatic cancer, novel treatment strategies, particularly antiinvasive antimetastatic are needed. The cytotoxic anticancer effects of juglone sodium selenite (NaSe) have been showed various cells.
 Objectives: In this study, it aimed to investigate synergistic selenium on PANC-1 BxPC-3 Methods: Antimetastatic juglone-NaSe...
The genotoxic effects of potassium sorbate (E202), sodium benzoate (E211) and nitrite (E250), which are in preservatives the classes food additives, were examined using micronucleus method human lymphocyte cultures. Concentrations prepared as 200 μg/ml, 500 μg/ml 1000 for sorbate, 100 300 800 benzoate, 1 10 respectively, according to Turkish Food Codex added culture. Our results indicated that, foods have no effect (p>0.05). However has every concentrations (p<0.05).
Granular corneal dystrophies (GCD) are characterized by small, discrete, sharp-edged, grayish-white opacities in the stroma. Among genes responsible for development of GCD, most strongly related gene is transforming growth factor beta-induced (TGFBI), located 5q31.1 locus. Studies show that R124H exon 4 and R555W 12 hot-spot mutations TGFBI lead to GCD development. In this study, we aimed investigate these two exons other possible same regions, which code important functional regions...
Ankaferd blood stopper (ABS) is a medical product that used in several injuries, dental operations, prevention of minor or major bleeding after spontaneous surgerical operations and have anti-microbial, anti-inflamatory, anti-thrombin, anti-platelet, anti-atherosclerotic, anti-oxidants effects. The present study aimed to evaluate the effects ABS on 8-hydroxy-2ˈ-deoxyguanosine (8-OHdG), superoxide dismutase (SOD), myeloperoxidase (MPO) levels over pleural adhesions rabbits with pulmonary...
Background/Aims: Juglone, as a naphthoquinone, has been shown to have cytotoxic and apoptotic effects in various cancer cells besides this it was reported anti-invasive anti-metastatic PANC-1 BxPC-3 our previous studies. In study, we investigated the of juglone on GRP75, TFAM mTOR genes encoding key proteins associated with mitochondrial biogenesis activation pancreatic since mitochondria central roles cell survival, metastasis therapeutic resistance. Methods: study; 5, 10, 15 20 μM doses...
Objective: Chemotherapy is still the most common and primary treatment option for treating pancreatic cancers because metastasis has already occurred at time of diagnosis, difficulties operation due to its location, lack targeted approaches.Moreover, high chemoteuropatic resistance seen in cancer makes research on alternative drug treatments mandatory.Juglone, a natural naphthaquinone found members Juglandaceae family, various pharmacological effects such as antiviral antibacterial.It also...
To determine the micronucleus (MN) frequency of acquired cholesteatoma tissue using an MN assay.Eighteen patients were diagnosed as having chronic otitis media with and divided into primary secondary groups. Cholesteatoma normal specimens from external ear canal skin taken during surgical operations. frequencies control samples determined according to standard criteria.The tissues 0.54%+/-0.31% 0.24%+/-0.11%, respectively (p<0.01). for groups 0.63%+/-0.36% 0.46%+/-0.26%, (p>0.05). in without...
Objective: The pancreas is a vital organ that produces metabolic hormones and enzymes.Type II diabetes either arises from defective insulin secretion pancreatic beta-cell cells or diminished mass.The possible effects of grape seed extract on various diseases have been investigated in recent years.This study was designed to determine the effect therapy mass.Methods: Twenty-five rats were partitioned five groups: control, treatment groups which administered 100, 200, 400 mg/kg extract,...