A5020175389- PI3K/AKT/mTOR signaling in cancer
- Chronic Myeloid Leukemia Treatments
- Microtubule and mitosis dynamics
- Quinazolinone synthesis and applications
- Cancer Mechanisms and Therapy
- Cancer Cells and Metastasis
- Cancer-related Molecular Pathways
- Retinoids in leukemia and cellular processes
- Chronic Lymphocytic Leukemia Research
- Enzyme function and inhibition
- Cancer-related molecular mechanisms research
- Histone Deacetylase Inhibitors Research
- Wnt/β-catenin signaling in development and cancer
- Epigenetics and DNA Methylation
- DNA Repair Mechanisms
- Tea Polyphenols and Effects
- Antioxidant Activity and Oxidative Stress
- Cell death mechanisms and regulation
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Electrochemical sensors and biosensors
- Phytochemicals and Antioxidant Activities
- Hepatitis B Virus Studies
- Cholinesterase and Neurodegenerative Diseases
- Eosinophilic Disorders and Syndromes
- FOXO transcription factor regulation
Muğla University
2023-2024
Ege University
2017-2023
Selçuk University
2014-2016
Long non-coding RNAs (lncRNAs) have been implicated in numerous biological processes, including epigenetic regulation, cell-cycle control, and transcriptional/translational regulation of gene expression. Differential expression lncRNAs disruption the regulatory processes are recognized as critical steps cancer development. The role hepatitis B virus (HBV) infection is not well understood. Here we analyzed 135 plasma samples 82 HBV patients (classified chronic patients, inactive carriers, or...
Insulin receptor substrate 1 (IRS1), plays a critical role in insulin signaling and its control has an important place the development of resistance. The tyrosine phosphorylation IRS1 serves as docking molecules for downstream effectors such Phosphatidylinositol 3-kinase phosphotyrosine phosphatase-2. We focused on Gly972Arg Ala513Pro variants gene, since these specific allelic are located near Tyr-Met-X-Met (YMXM) motifs around Tyr987 Tyr612. Thus, we aimed to investigate effects...
Objectives: Lung cancer (LC) is one of the most prevalent cancers with highest fatality rate worldwide. Long noncoding RNAs (lncRNAs) are being considered potential new molecular targets for early diagnosis, follow-up, and individual treatment decisions in LC. Therefore, this study evaluated whether lncRNA expression levels obtained from exhaled breath condensate (EBC) samples play a role occurrence metastasis diagnosis follow-up patients advanced lung adenocarcinoma (LA). Methods: A total...
PI3K/Akt/mTOR pathway activation causes relapse and resistance after radiotherapy in breast cancer (BC). We aimed to radiosensitize BC cell lines irradiation (IR) by PKI-402, a dual PI3K/mTOR inhibitor.We performed cytotoxicity, clonogenicity, hanging drop, apoptosis double-strand break detection, phosphorylation of 16 essential proteins involved the pathway.Our findings showed that PKI-402 has cytotoxic efficiency all lines. Clonogenic assay results plus IR inhibited colony formation...
Abstract The effect of Wnt pathway in head and neck cancer could not be elucidated, even though the aberrant signaling plays a key role development many types cancer. inhibitor β‐catenin responsive transcription (ICRT‐3) blocks by binding to β‐catenin, which is coactivator promising agent for inhibiting signaling. In our study, we aimed evaluate ICRT‐3 on cytotoxicity, apoptosis, cell cycle progression, migration, gene expressions stem (HNCSC) hypopharynx this compound cytotoxicity viability...
A recombinant carbonic anhydrase (CA, EC 4.2.1.1) from the soil-dwelling bacterium Enterobacter sp. B13 was cloned and purified by Co2+ affinity chromatography. Bioinformatic analysis showed that new enzyme (denominated here B13-CA) belongs to β-class CAs possess 95% homology with ortholog Escherichia coli encoded can gene, whereas its sequence other such E. (encoded cynT gene) of 33%. B13-CA characterized kinetically as a catalyst for carbon dioxide hydration bicarbonate protons. The shows...
Dysregulation of the cell cycle is one main causes melanomagenesis. Genomewide studies showed that expression Aurora -A and -B significantly has been upregulated in melanoma. However, there no FDA approved drug targeting aurora kinases treatment In addition, development resistance to chemotherapeutic agents melanoma and, as a result, relapse due heterogeneous groups patients second phenomenon failure. Therefore, an urgent need for therapeutic alternatives both Melanoma Cancer Stem Cells...
Objective: A relationship exists between breast cancer stem cells (BCSCs) and the chemo-resistance recurrence of aggressive tumors. Amcasertib is a small chemical compound multiple kinase inhibitor that inhibits downstream Nanog other signaling pathways in by targeting several serine-threonine kinases. In this study, we aimed to investigate cytotoxicity anticancer effects on BCSCs, gaining insight into targetability BCSCs. Method: We used combined xCELLigence-Real-Time Cell Analyzer (RTCA)...
To evaluate the effect of combination irradiation and AZD0156 on apoptosis, cell cycle progression, clonogenic survival in human breast cancer fibroblast cells.Estrogen receptor-positive line MCF-7 healthy lung WI-38 were obtained. Following employing proliferation analysis, cytotoxicity analysis was done to calculate IC50 values lines. application irradiation, flow cytometry performed for evaluating distribution extent apoptosis. Plating efficiency surviving fraction calculated assay.SPSS...
Background: Salinomycin, an ionophore antibiotic, is known to be effective agent in reducing the viability of Glioblastoma (GBM) cells. The combination salinomycin with other chemotherapeutic drugs would help overcome drug resistance GBM Objective: This study aims test combinatorial effect and AZD3463 T98G Methods: cytotoxic effects on cells were determined by using WST-8 assay. Flow cytometry was used identify apoptosis cell cycle profiles after treatments. Real-time PCR portray mRNA...
Since December 2019, an outbreak of a novel coronavirus (SARS-CoV-2) infection causing COVID-19 disease has influenced the whole world. Angiotensin converting enzyme 2 (ACE2) receptors on type pneumocytes in humans were determined as entry for SARSCoV- 2. Receptor binding and subsequently endocytosis ACE2 diminish cell membrane expression also function ACE2. is involved bradykinin metabolism. Lys-des-Arg9-BK occured with enzymatic cleaving Lys-BK derived from low molecular weight kininogen...
Abstract Objectives Recently, phenolic compounds (quercetin, kaempferol, ellagic acid (EA), and myricetin) as natural sources have been suggested to be used for treatment chemoprevention of prostate cancer. Since rosehip includes the above molecules in high concentration, we set out investigate possible anti-proliferative effect tea on cancer cell line. Methods The flavonol content prepared at different temperatures time intervals was determined first then antiproliferative samples...
Amaç: Serin/treonin protein kinaz olan aurora kinazlar, hücrelerin uygun mitotik ilerlemeden sorumlu önemli moleküllerdir.Kanser hücrelerinde anormal olarak ifade edildikleri bilinmekte ve bu nedenle bir terapötik hedefler görülmektedir.CCT137690, yüksek oranda seçici özellik gösteren sentetik inhibitörüdür.Bu çalışmada CCT137690'un KU812 hücreleri (insan kronik miyeloid lösemi-KML) üzerinde apoptotik antiproliferatif etkilerinin belirlenmesi