A5088201390- Chronic Myeloid Leukemia Treatments
- Chronic Lymphocytic Leukemia Research
- Quinazolinone synthesis and applications
- Acute Myeloid Leukemia Research
- PI3K/AKT/mTOR signaling in cancer
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Cell death mechanisms and regulation
- Circular RNAs in diseases
- Hepatitis B Virus Studies
- Hepatitis C virus research
- RNA Interference and Gene Delivery
- Microtubule and mitosis dynamics
- MicroRNA in disease regulation
- Cancer therapeutics and mechanisms
- Advanced biosensing and bioanalysis techniques
- Retinoids in leukemia and cellular processes
- Cancer Mechanisms and Therapy
- Synthesis and Reactivity of Heterocycles
- Histone Deacetylase Inhibitors Research
- RNA modifications and cancer
- Pharmacovigilance and Adverse Drug Reactions
- Tannin, Tannase and Anticancer Activities
- Nanoparticles: synthesis and applications
- Liver Disease Diagnosis and Treatment
Ege University
2011-2023
Bakırçay Üniversitesi
2021-2023
Izmir University
2021-2023
Selçuk Üniversitesi Tıp Fakültesi Hastanesi
2015
Long non-coding RNAs (lncRNAs) have been implicated in numerous biological processes, including epigenetic regulation, cell-cycle control, and transcriptional/translational regulation of gene expression. Differential expression lncRNAs disruption the regulatory processes are recognized as critical steps cancer development. The role hepatitis B virus (HBV) infection is not well understood. Here we analyzed 135 plasma samples 82 HBV patients (classified chronic patients, inactive carriers, or...
Abstract ASP was used to synthesize FeNP A . They were characterized by UV-vis spectroscopy, FT-IR, TEM, SEM, XRD and ZP. The aim of this study evaluate in vitro cytotoxic activity antioxidant acitivities properties evaluated using DPPH, ABTS + H 2 O assays. had higher comparing according DPPH (IC 50 : 3.48 μg/mL) (60.52%) Anti-cancer activities investigated breast cancer, melanoma control cell lines. more than MCF-7, MeWo, CHL-1, HEL 299 cells. shown that mitochondria induce apoptosis...
Abstract The effect of Wnt pathway in head and neck cancer could not be elucidated, even though the aberrant signaling plays a key role development many types cancer. inhibitor β‐catenin responsive transcription (ICRT‐3) blocks by binding to β‐catenin, which is coactivator promising agent for inhibiting signaling. In our study, we aimed evaluate ICRT‐3 on cytotoxicity, apoptosis, cell cycle progression, migration, gene expressions stem (HNCSC) hypopharynx this compound cytotoxicity viability...
PI3K/Akt/mTOR pathway activation causes relapse and resistance after radiotherapy in breast cancer (BC). We aimed to radiosensitize BC cell lines irradiation (IR) by PKI-402, a dual PI3K/mTOR inhibitor.We performed cytotoxicity, clonogenicity, hanging drop, apoptosis double-strand break detection, phosphorylation of 16 essential proteins involved the pathway.Our findings showed that PKI-402 has cytotoxic efficiency all lines. Clonogenic assay results plus IR inhibited colony formation...
Abstract Background The optimal radiobiological model, which assesses the biological effects of novel radiotherapy techniques that concurrently modify multiple physical factors, has not yet been defined. This study aimed to investigate impact intensity‐modulated (IMRT) and volumetric‐modulated arc therapy (VMAT) on cellular response in head neck cancer melanoma models. Methods Clonogenic analysis, DNA double‐strand break apoptosis, cell cycle analysis were performed stem models, normal...
Dysregulation of the cell cycle is one main causes melanomagenesis. Genomewide studies showed that expression Aurora -A and -B significantly has been upregulated in melanoma. However, there no FDA approved drug targeting aurora kinases treatment In addition, development resistance to chemotherapeutic agents melanoma and, as a result, relapse due heterogeneous groups patients second phenomenon failure. Therefore, an urgent need for therapeutic alternatives both Melanoma Cancer Stem Cells...
Hepatitis B is a significant public health issue worldwide. Long noncoding RNAs (lncRNAs) are pivotal in biological mechanisms. The involvement of lncRNAs hepatitis remains incompletely understood. This study sought to explore the potential certain as diagnostic and prognostic markers B, their ability differentiate between clinical disease subgroups.
The aim of the study is to examine cytotoxic, apoptotic effects and gene expressions Asphodelus aestivus water extract (ASP) silver nanoparticles (AgNPS) on decided cancer lines.Breast cell lines MCF-7 MDA-231; melanoma MEWO CHL-1; fibroblast WI-38 HEL 299 were selected for biological activities.xCELLigence system was used cytotoxicity.Annexin V-EG FP Apoptosis detection kit apoptosis assessed by real time online RT-PCR using Qiagen kits.AgNPS showed significant cytotoxicity in all lines.The...
Amaç: t(4;11), MLL-AF4 translokasyonu sonucu oluşan, 4q21 kromozomal bandına yerleşim gösteren AF4 geninin 11q23 MLL genine füzyonu gelişen bir anomalidir. Bu çalışmada, retrospektif olarak 2009-2013 yılları arasındaki akut lenfoblastik lösemi (ALL) hastalarındaki t(4;11) translokasyonunun analiz sonuçlarının incelenmesi amaçlandı. Gereç ve Yöntem: Ege Üniversitesi Tıp Fakültesi Tıbbi Biyoloji Anabilim Dalı'na arasında ön tanısıyla 176 çocuk (70 kız, 106 erkek) 144 yetişkin (60 kadın, 84...
Amaç: Bu çalışmada, Ege Üniversitesi Tıp Fakültesi Tıbbi Biyoloji Anabilim Dalı'na 2009-2013 yılları arasında akut myeloid lösemi (AML) ön tanısı ile başvuran 402 olgunun (322 yetişkin, 80 çocuk) kan veya kemik iliği örneklerinin inv16 kantitasyon analizlerinin RT-PCR yöntemi değerlendirilmesi amaçlandı. Gereç ve Yöntem: Hastalardan alınan örneklerinden total RNA/mRNA izolasyonunu takiben cDNA'ları elde edilerek revers-transkriptaz-polimeraz zincir reaksiyonu (RT-PCR) yöntemiyle kantitasyonu...