A5058853956- Hearing, Cochlea, Tinnitus, Genetics
- Hearing Loss and Rehabilitation
- Neuroscience and Neuropharmacology Research
- Vestibular and auditory disorders
- Biochemical Analysis and Sensing Techniques
- Neural Networks and Applications
- Sleep and Wakefulness Research
- Spaceflight effects on biology
- Developmental Biology and Gene Regulation
- Congenital heart defects research
- Neurogenesis and neuroplasticity mechanisms
- Circadian rhythm and melatonin
- Genetics, Aging, and Longevity in Model Organisms
- Neurotransmitter Receptor Influence on Behavior
- Pharmacological Receptor Mechanisms and Effects
- Memory and Neural Mechanisms
- Medical and Health Sciences Research
- Marine animal studies overview
- Zebrafish Biomedical Research Applications
Harvard University
2014-2025
Medical University of Białystok
1999-2000
Significance The nematode Caenorhabditis elegans offers the opportunity to map complex behaviors specific roles of each neuron in a 302-neuron nervous system. Thermotaxis is behavior where worm inverts behavioral mode—positive thermotaxis up gradients or negative down gradients—to move toward remembered temperature. How are both long-term memory and multiple modes encoded? A long-standing model has been that separate circuits for positive compete control body movement. In contrast, we find...
Abstract The brain controls nearly all bodily functions via spinal projecting neurons (SPNs) that carry command signals from the to cord. However, a comprehensive molecular characterization of brain-wide SPNs is still lacking. Here we transcriptionally profiled total 65,002 SPNs, identified 76 region-specific SPN types, and mapped these types into companion atlas whole mouse 1 . This taxonomy reveals three-component organization SPNs: (1) molecularly homogeneous excitatory cortex, red...
Brainstem olivocochlear neurons (OCNs) modulate the earliest stages of auditory processing through feedback projections to cochlea and have been shown influence hearing protect ear from sound-induced damage. Here, we used single-nucleus sequencing, anatomical reconstructions, electrophysiology characterize murine OCNs during postnatal development, in mature animals, after sound exposure. We identified markers for known medial (MOC) lateral (LOC) OCN subtypes, show that they express distinct...
The sense of hearing originates in the cochlea, which detects sounds across dynamic sensory environments. Like other peripheral organs, cochlea is subjected to environmental insults, including loud, damage-inducing sounds. In response internal and external stimuli, central nervous system directly modulates cochlear function through olivocochlear neurons (OCNs), are located brainstem innervate epithelium. One population OCNs, lateral (LOC) neurons, target spiral ganglion (SGNs), primary ear....
ABSTRACT The sense of hearing originates in the cochlea, which detects sounds across dynamic sensory environments. Like other peripheral organs, cochlea is subjected to environmental insults, including loud, damage-inducing sounds. In response internal and external stimuli, central nervous system directly modulates cochlear function through olivocochlear neurons (OCNs), are located brainstem innervate epithelium. One population OCNs, lateral (LOC) neurons, target spiral ganglion (SGNs),...
SUMMARY Brainstem olivocochlear neurons (OCNs) modulate the earliest stages of auditory processing through feedback projections to cochlea and have been shown influence hearing protect ear from sound-induced damage unclear mechanisms. Here, we used single-nucleus sequencing, anatomical reconstructions, electrophysiology characterize OCNs during postnatal development after sound exposure. We identified markers for known OCN subtypes, medial (MOC) lateral (LOC) OCNs, show that they express...