To determine whether there is a significant correlation between optic nerve head circulation determined by pulse wave analysis of laser speckle flowgraphy (LSFG), and the cardio-ankle vascular index (CAVI), left ventricular (LV) function, age.Forty-nine men who visited Vascular Function Section Toho University Sakura Medical Center, Chiba, Japan were studied. The mean age subjects was 60.7±10.6 years (range 29 to 80 years). CAVI, ejection fraction (LVEF) as function systolic LV early...

We investigated whether intravitreal infusion solution containing epinephrine affects optic nerve head (ONH) blood flow during vitreous surgeries.The subjects were 22 patients with epimacular membrane or idiopathic macular hole. During surgery, ONH was examined before and 10 minutes after of epinephrine, via a laser speckle flowgraphy (LSFG) technique modified for acquiring measurements in supine position. Epinephrine concentration set at 1.0 mg/500 mL (1:500,000) 0.5 (1:1,000,000), each...

To investigate the short-term effects of 2 new secretagogue eye drops for dry eye, 3% diquafosol tetrasodium ophthalmic solution (diquafosol) and 2% rebamipide suspension (rebamipide), on concentration mucin 5AC (MUC5AC) in rabbit tear fluid conjunctival goblet cells.One dose artificial tears, or rebamipide, was instilled into 8 eyes Japanese white rabbits. MUC5AC examined using enzyme-linked immunosorbent assay 15 min after instillation compared with untreated controls. Impression cytology...

The purpose of this study was to determine whether there were significant correlations between the pulse waveform in capillary area optic nerve head (ONH) microcirculation shown by laser speckle flowgraphy (LSFG) and parameters systemic condition, especially cardio-ankle vascular index (CAVI). We studied 130 men (ages 60.5 ± 10.9 years) who visited Vascular Function Section Department Cardiovascular Center Toho University Sakura Medical Center. evaluated skew blowout time (BOT) — which are...

To characterize laser speckle flowgraphy (LSFG) pulse waveform parameters for ocular circulation evaluation, a multicenter, prospective, cross-sectional study was conducted in 111 eyes of 86 healthy Japanese individuals. Optic nerve head (ONH) tissue-area, vessel-area mean blur rate (MT and MV, respectively), MT MV were obtained using LSFG ONH structural planimetry. Multivariate linear mixed-effects modeled regression analysis identified factors contributing to MT- or MV-waveforms age,...

Abstract Potential differences in the nature of influences aging and gender on optic nerve head (ONH) microcirculation, using laser speckle flowgraphy (LSFG) were evaluated. We studied 908 healthy subjects (men = 701, age: 50.0 ± 9.1 yrs, women 208, 49.8 9.5 p 0.76). The average, maximum (Max), minimum (Min) mean blur rate (MBR) a heartbeat parameters analyzed separately for tissue, vessels, throughout ONH (All). investigated which MBR sections are correlated with age by univariate...

Purpose: To investigate the ocular and systemic factors related to glaucoma be adjusted for interindividual comparison of blood flow measurement results by laser speckle flowgraphy (LSFG) obtained from optic nerve head (ONH) in normal Japanese individuals. Methods: A multicenter, prospective cross-sectional study was conducted. The ONH tissue-area vessel-area mean blur rate (MT MV) were evaluated using LSFG structural parameters planimetric methods. Multivariate linear mixed-effects modeled...

Aim. To determine whether there is a significant correlation between the optic nerve head (ONH) circulation determined by laser speckle flowgraphy (LSFG) and kidney function. Materials. Seventy-one subjects were investigated. The estimated glomerular filtration rate (GFR) serum creatinine, cystatin C, urinary albumin excretion measured. ONH was an analysis of pulse wave LSFG, this parameter named blowout time (BOT). Chronic disease (CKD) defined to be present when GFR <60 mL/min per 1.73...

A novel arterial stiffness index, the cardio-ankle vascular index (CAVI), has been proposed. To clarify properties of CAVI, effects beraprost sodium (BPS), a prostaglandin (PG) I2 analogue, which potent vasodilating effect, on CAVI were studied and comparing with brachialankle pulse wave velocity (baPWV) in healthy volunteers.Male volunteers (n=18, 46.3±4.2 yr) enrolled this study administered BPS (40 µg). baPWV measured every hour for 4 hours.When was to 18 volunteers, systolic blood...

&lt;b&gt;&lt;i&gt;Purpose:&lt;/i&gt;&lt;/b&gt; To evaluate the risk factors for acute atherothrombotic events in patients with exudative age-related macular degeneration (AMD) without a history of coronary artery disease or stroke. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; Two hundred fifty-nine patents AMD were evaluated carotid atherosclerosis, peripheral arterial disease, and chronic kidney (CKD). &lt;b&gt;&lt;i&gt;Results:&lt;/i&gt;&lt;/b&gt; A mean intima-media thickness ≥1.0 mm...

Measuring the ocular blood flow in neonates may clarify relationships between eye diseases and circulation abnormalities. However, no method for noninvasively measuring is established. We used laser speckle flowgraphy (LSFG) modified to measure their investigated whether this reproducible. During normal sleep, we studied 16 subjects (adjusted age of 34–48 weeks) whose could be measured three consecutive times. While slept supine position, mean blur rate (MBR) values optic nerve head (ONH)...

Abstract The influences of age and gender differences on the pulse waveform in optic nerve head (ONH) healthy adults, using laser speckle flowgraphy (LSFG) were evaluated. We studied 908 subjects (men = 701, age: 50.0 ± 9.1, women 208, 49.8 9.5, p 0.76), evaluating these parameters: blowout score (BOS), time (BOT), acceleration index (ATI), rising falling rates. parameters analyzed separately for tissue, vessels, throughout (All). All compared between genders. investigated which independent...

We report on a patient with ischemic colitis and another paralytic ileus, both of whom experienced an acute abdomen after intravitreal injection bevacizumab (IVB). Case 1 was 78-year-old woman. Her medical history included surgery for colon carcinoma 10 years earlier. The developed severe abdominal pain nausea the day IVB retinal vein occlusion macular edema, massive lower gastrointestinal bleeding occurred. Ischemic diagnosed. 2 64-year-old man who presented neovascular glaucoma...

Purpose. To clarify whether the incidence of metabolic syndrome (MetS) and overlap MetS components are affecting ocular circulation shown by laser speckle flowgraphy (LSFG). Materials Methods. We studied 76 consistent patients. Blowout score (BOS) blowout time (BOT), which pulse waveform analysis parameters, mean blur rate (MBR) using LSFG in optic nerve head (ONH) choroid were evaluated. Throughout, ONH was separated out from vessels tissue for MBRs divided into four sections (superior,...

To evaluate the relationships between optic nerve head (ONH) blood flow by laser speckle flowgraphy (LSFG), and postmenstrual age body weight in normal neonates. During their sleep, we studied 24 infants (postmenstrual age, 248–295 days) whose ocular could be measured three consecutive times. While subjects slept supine position, mean blur rate (MBR) values of ONH were obtained: MBR-A (mean all values), MBR-V (vessel mean) MBR-T (tissue ONH. With regard to eye diseases, no retinopathy...

Purpose We examined the effects of aging and exercise habits on ocular blood flow (OBF) its profiles throughout optic nerve head region choroidal area. hypothesized that reduce stiffness vessels in circulation, which generally increases with aging. Methods Participants a medical checkup program (698 males 192 females aged 28 to 80 years) were categorized into 2 groups (with without habits) based participant self-reporting definition Ministry Health, Labor Welfare Japan (MHLW). OBF right eye...