A5087168188- Viral gastroenteritis research and epidemiology
- Virus-based gene therapy research
- Viral Infections and Immunology Research
- Respiratory viral infections research
- Advanced Thermodynamic Systems and Engines
- Vitamin C and Antioxidants Research
- Viral-associated cancers and disorders
- Escherichia coli research studies
- Child Nutrition and Water Access
- Immune Cell Function and Interaction
- Neonatal Respiratory Health Research
- Lymphoma Diagnosis and Treatment
- Animal Virus Infections Studies
- Clostridium difficile and Clostridium perfringens research
- Gut microbiota and health
- Neonatal Health and Biochemistry
- Cytomegalovirus and herpesvirus research
University of Pittsburgh
2020-2025
Children's Hospital of Pittsburgh
2020-2024
University of Florida
2015-2021
University of Florida Health
2014
University Medical Center Freiburg
1996
University of Freiburg
1996
Gammaherpesviruses such as Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (KSHV, HHV-8) establish lifelong latency in their hosts are associated with the development of several types malignancies, including a subset B cell lymphomas. These viruses thought to co-opt process differentiation latently infect fraction circulating memory cells, resulting establishment stable setpoint. However, little is known about how this infected compartment maintained throughout life...
Abstract Human noroviruses are the leading cause of severe childhood diarrhea worldwide, yet we know little about their pathogenic mechanisms. Murine in interferon-deficient adult mice but these hosts also develop systemic pathology and lethality, reducing confidence translatability findings to human norovirus disease. Herein report that a murine causes self-resolving absence disease wild-type neonatal mice, thus mirroring key features representing small animal model mice. Intriguingly,...
Many functions of viral attachment proteins are established, but less is known about the biological importance protein encapsidation efficiency. The mammalian orthoreovirus (reovirus) σ1 forms filamentous trimers that incorporate into pentamers λ2 capsid protein. Reovirus strains vary in efficiency onto progeny virions, which influences stability during entry cells and efficacy tumor cell lysis. While role has been evaluated studies using cultured cells, contribution to infection animals...
Interferons (IFNs) are key controllers of viral replication, with intact IFN responses suppressing virus growth and spread. Using the murine norovirus (MNoV) system, we show that IFNs exert selective pressure to limit pathogenic evolutionary potential this enteric virus. In animals lacking type I signaling, nonlethal MNoV strain CR6 rapidly acquired enhanced virulence via conversion a single nucleotide. This nucleotide change resulted in amino acid substitution F514I capsid, which led...
ABSTRACT Serotype 3 (T3) strains of mammalian orthoreovirus (reovirus) spread to the central nervous system infect brain and cause lethal encephalitis in newborn mice. Although reovirus targets several regions brain, susceptibility infection is not uniformly distributed. The neuronal subtypes anatomic sites targeted throughout are precisely known. Reovirus binds attachment factors entry receptors, including sialic acid (SA)-containing glycans paired immunoglobulin-like receptor B (PirB)....
ABSTRACT Human noroviruses are the leading cause of severe childhood diarrhea worldwide yet we know very little about their pathogenic mechanisms. Murine in interferon-deficient adult mice but these hosts also develop systemic pathology and lethality, reducing confidence translatability findings to human norovirus disease. Herein report that a murine causes self-resolving absence disease wild-type neonatal mice, thus mirroring key features representing robust small animal model....