A5043263176- SARS-CoV-2 and COVID-19 Research
- interferon and immune responses
- Viral gastroenteritis research and epidemiology
- COVID-19 Clinical Research Studies
- NF-κB Signaling Pathways
- Cancer Treatment and Pharmacology
- Lipid Membrane Structure and Behavior
- Long-Term Effects of COVID-19
- Parasitic Infections and Diagnostics
- Immunotherapy and Immune Responses
- Viral Infections and Immunology Research
- Autophagy in Disease and Therapy
- Radio Frequency Integrated Circuit Design
- Cancer-related Molecular Pathways
- Advanced Power Amplifier Design
- Diet and metabolism studies
- Child Nutrition and Water Access
- Receptor Mechanisms and Signaling
- Therapeutic Uses of Natural Elements
- COVID-19 and healthcare impacts
- Cholesterol and Lipid Metabolism
- Genetic factors in colorectal cancer
- Endoplasmic Reticulum Stress and Disease
- Multiple and Secondary Primary Cancers
- 14-3-3 protein interactions
Washington University in St. Louis
2020-2025
Samsung (South Korea)
2021-2024
Sungkyunkwan University
2020-2023
Ajou University
2011
Chungbuk National University
2007
Significance The novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the etiological agent of coronavirus disease-2019 (COVID-19), has swept world in unprecedented speed. In a few months, SARS-CoV-2 infected millions people and caused tens thousands deaths. There are no Food Drug Administration-approved antivirals or vaccines yet available clinical treatments limited to supportive therapies that help alleviate symptoms. Thus, there is an urgent need identify effective as...
Cryptosporidiosis is a major cause of severe diarrheal disease in infants from resource poor settings. The majority infections are caused by the human-specific pathogen C. hominis and absence vitro growth platforms has limited our understanding host-pathogen interactions development effective treatments. To address this problem, we developed stem cell-derived culture system for using human enterocytes differentiated under air-liquid interface (ALI) conditions. Human ALI cultures supported...
DNA methylation is one of the most important epigenetic modifications in living organisms and its application ecology becoming increasingly widespread. Based on collection review relevant literature ecological epigenetics, this paper introduces principles, advantages, limitations Methylation-Sensitive Amplified Polymorphism (MSAP) technology, as well applications prospects ecology. MSAP has become a powerful tool for studying levels due to wide ease operation. It particularly useful...
The coronavirus disease 2019 (COVID-19), the caused by SARS-CoV-2 infection, is an ongoing public health disaster worldwide. Although several vaccines are available as a preventive measure and FDA approval of orally bioavailable drug on horizon, there remains need for developing antivirals against that could work early course infection.
Toll-like receptors (TLRs) induce the activation of nuclear factor kappa-light-chain-enhancer activated B cells (NF-κB) and autophagy through TNF (Tumor necrosis factor) receptor-associated 6 (TRAF6)-evolutionarily conserved signaling intermediate in Toll pathways (ECSIT) TRAF6-BECN1 axes, respectively. Having shown that p62 negatively regulates receptor 4 (TLR4)-mediated via TRAF6-ECSIT axis, we herein investigated whether is functionally implicated thereby regulating cancer cell migration...
Hepatitis B virus X (HBx) protein has been reported as a key regulating the pathogenesis of HBV-induced hepatocellular carcinoma (HCC). Recent evidence shown that HBx is implicated in activation autophagy hepatic cells. Nevertheless, precise molecular and cellular mechanism by which induces still controversial. Herein, we investigated involved TRAF6-BECN1-Bcl-2 signaling for regulation response to TLR4 stimulation, therefore influencing HCC progression. interacts with BECN1 (Beclin 1)...
Summary Background Urticaria is the commonest cutaneous reaction caused by aspirin or other nonsteroidal anti-inflammatory drugs. The pathogenesis of aspirin-induced urticaria (AIU) not fully understood, but appears to involve mast cell activation and neutrophil infiltration. Objectives To investigate genetic contribution interleukin (IL)-18, which can amplify acute inflammation promoting activation, migration cytokine production, AIU. Methods A case–control association study was performed...
TRAF6-BECN1 signaling axis is critical for autophagy induction and functionally implicated in cancer progression. Here, we report that AMP-activated protein kinase alpha 1 (AMPKα1, PRKAA1) positively involved progression by regulating axis. Mechanistically, AMPKα1 interacted with TRAF6 BECN1. It also enhanced ubiquitination of BECN1 induction. AMPKα1-knockout (AMPKα1KO) HEK293T or AMPKα1-knockdown (AMPKα1KD) THP-1 cells showed impaired induced serum starvation TLR4 (Toll-like receptor 4)...
Abstract Cholesterol 25-hydroxylase (CH25H) is an interferon-stimulated gene (ISG) that shows broad antiviral activities against a wide range of enveloped viruses. Here, using ISG screen VSV-SARS-CoV and VSV-SARS-CoV-2 chimeric viruses, we identified CH25H its enzymatic product 25-hydroxycholesterol (25HC) as potent inhibitors virus replication. Mechanistically, internalized 25HC accumulates in the late endosomes blocks cholesterol export, thereby restricting SARS-CoV-2 spike protein...
The abnormal proliferation of vascular smooth muscle cells (VSMCs) in arterial walls is an important pathogenetic factor disorders such as atherosclerosis and restenosis after angioplasty. Epothilone B, a novel potential antitumor compound, has potent effect on preventing postangioplasty restenosis. Therefore, we established vivo rat carotid injury model examined the effects epothilone B cardiovascular disease. We found that potently prevented neointimal formation VSMCs proliferation. In...
Abstract Pathogenic coronaviruses represent a major threat to global public health. Here, using recombinant reporter virus-based compound screening approach, we identified several small-molecule inhibitors that potently block the replication of newly emerged severe acute respiratory syndrome virus 2 (SARS-CoV-2). Among them, JIB-04 inhibited SARS-CoV-2 in Vero E6 cells with an EC 50 695 nM, specificity index greater than 1,000. showed vitro antiviral activity multiple cell types against DNA...
Abstract Introduction Coronavirus Disease 2019 (COVID-19) is an ongoing public health crisis that has sickened or precipitated death in millions. The etiologic agent of COVID-19, Severe Acute Respiratory Syndrome 2 (SARS-CoV-2), infects the intestinal epithelium, and can induce GI symptoms similar to human inflammatory bowel diseases (IBD). An international surveillance epidemiology study (SECURE-IBD) reported standardized mortality ratio trends higher IBD patients (1.5-1.8)...
As mobile applications have become more prevalent, the demand for higher network capacity and data rates has increased. This led to development of complicated platforms including RF transceivers that can support various frequency bands, a massive multiple-input multiple-output (MIMO), multiple carrier components (CCs) aggregations (CAs). paper presents fully integrated, versatile transceiver designed handle high achieve cost-efficient solution, incorporating techniques. The comprises 24...
ABSTRACT Cryptosporidiosis is a major cause of severe diarrheal disease in infants from resource poor settings. The majority infections are caused by the human-specific pathogen C. hominis and absence vitro growth platforms has limited our understanding host-pathogen interactions development effective treatments. To address this problem, we developed stem cell-derived culture system for using human enterocytes differentiated under air-liquid interface (ALI) conditions. Human ALI cultures...
최근 들어 ATSC-DTV의 미래형 핵심기술로 손꼽히고 있는 송신기 식별기술(TxID ; Transmitter Identification)이 새로운 신기술로 대두되고 있으며, 이에 대한 구현성 검증은 현재 활발하게 논의 중인 동일채널중계기(EDOCR)와 연계된 단일주파수망(SFN; Single Frequency Network)기술의 실용화를 위한 핵심적 역할을 한다고 볼 수 있다. 하지만 종래의 TxID 기술은 긴 주기의 워터마킹용 확산코드를 사용하므로 수신기 입장에서 하드웨어 부피 및 연산량이 크게 증가되는 문제점을 갖고 따라서 본 논문에서는 부피를 경감시킬 Decimation 알고리즘을 이용한 DTV 수신 신호의 효율적인 신호처리 기법을 제시하였으며, 모의실험을 통한 성능평가를 통해 제안한 알고리즘의 유용성을 입증하였다. Recently, Identification(TxID) technology has been issued as a of ATSC DTV. networks...
현재 국내 기업의 컴퓨터 종류별 보유치의 약 79%는 데스크톱으로 확인되고 있다. 대부분의 기업이 사용하는 데스크톱은 비인가 사용자도 데스크톱을 부팅하여 접근할 수 있는 문제점이 이를 보완하기 위해 BIOS 패스워드와 사용자 계정 로그인을 사용하지만, 이는 인증을 우회할 있어 취약하다. 이에 본 논문에서는 기존 데스크톱의 물리적 접근을 지문 인식과 전력 제어를 활용한 원격 부팅 시스템을 제안한다. 제안 시스템은 인식 기술을 이용해 수행한다. 그리고 시스템으로 전력을 제어함으로써 데스크톱 시스템의 접근 취약점을 극복한다. 통해 취약점에 대한 보안성을 높인 부팅이 가능하다.