A5054885541- Diabetes and associated disorders
- Diabetes Management and Research
- Pancreatic function and diabetes
- Diabetes, Cardiovascular Risks, and Lipoproteins
- COVID-19 Impact on Reproduction
- COVID-19 Clinical Research Studies
- Diabetes Management and Education
- Obesity, Physical Activity, Diet
- Diabetes Treatment and Management
- Lipoproteins and Cardiovascular Health
- Kawasaki Disease and Coronary Complications
- Maternal Mental Health During Pregnancy and Postpartum
- Child Nutrition and Water Access
- Childhood Cancer Survivors' Quality of Life
- Thyroid Disorders and Treatments
- Congenital heart defects research
- Adolescent and Pediatric Healthcare
- Body Composition Measurement Techniques
- Diet, Metabolism, and Disease
- Digestive system and related health
- Vitamin D Research Studies
- COVID-19 and Mental Health
- Epigenetics and DNA Methylation
- Lysosomal Storage Disorders Research
- Immune Cell Function and Interaction
Ministry of Health
2012-2025
Farwaniya Hospital
2015-2025
Dasman Diabetes Institute
2018-2025
Kuwait University
2012
OBJECTIVE Insulin delivery methods, glucose-monitoring modalities, and related outcomes were examined in a large, international, diverse cohort of children adolescents with type 1 diabetes from the Better Control Pediatric Adolescent Diabetes: Working to Create Centers Reference (SWEET) -Registry. RESEARCH DESIGN AND METHODS Participants ≥1 year, aged ≤18 years, who had documented pump or sensor usage during period August 2017–July 2019 stratified into four categories: injections–no...
Abstract Background An increasing proportion of women are infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during pregnancy. Intrauterine viral infections induce an increase in the levels proinflammatory cytokines, which inhibit proliferation neuronal precursor cells and stimulate oligodendrocyte cell death, leading to abnormal neurodevelopment. Whether a maternal cytokine storm can affect neonatal brain development is unclear. The objective present study was assess...
Abstract We examined the frequency and severity of diabetic ketoacidosis (DKA) in 679 children adolescents (0–14 years) at diagnosis Type 1 Diabetes Mellitus (T1DM) Kuwait. Between st January 2011 31 December 2013, all newly diagnosed with diabetes were registered prospectively a population-based electronic register. DKA was using standard criteria based on levels venous pH serum bicarbonate. At time diagnosis, mild/moderate present 24.8% children, while severe 8.8%. Incidence significantly...
AIMS This study had 2 aims: to report data on the incidence of childhood-onset type 1 diabetes in Kuwaiti children aged 0-14 years during 2011 2013 and compare recent with those collected 1992 1997. METHODS All newly diagnosed patients were registered through Childhood-Onset Diabetes eRegistry (CODeR) 2011-2013, based DiaMond protocol used 1992-1997. RESULTS A total 515 (247 boys 268 girls) from January 31 December 2013. Data ascertainment 96.7%. The mean age ± SD at diagnosis was 8.7 3.4...
Identifying genes linked to extreme phenotypes in humans has the potential highlight biological processes not shared with all other mammals. Here, we report identification of homozygous loss-of-function variants primate-specific gene ZNF808 as a cause pancreatic agenesis. is member KRAB zinc finger protein family, large and rapidly evolving group epigenetic silencers which target transposable elements. We show that loss vitro results aberrant activation regulatory contained elements it...
Type 1 diabetes mellitus (T1DM) is highly prevalent in Kuwait with incidence of around 40.1/100,000 individuals. Evidence indicate that vitamin D plays an important role modulating the immune system and could thus impact onset high prevalence T1DM. We report serum levels Kuwaiti children T1DM non-diabetic controls to explore its relationship disease.This study included 216 Arab The diagnosis was based on ISPAD criteria. control subjects (204 Kuwaitis) were age gender matched, healthy,...
Objective: In recent decades, the Arab population has experienced an increase in prevalence of type 2 diabetes (T2DM), particularly within Gulf Cooperation Council. this context, early intervention programmes rely on ability to identify individuals at risk T2DM. We aimed build prognostic models for T2DM using machine-learning algorithms vs. conventional logistic regression (LR) and simple non-invasive clinical markers over three different time scales (3, 5, 7 years from baseline). Design:...
Multisystem inflammatory syndrome in children (MIS-C) is a severe complication arising from SARS-CoV-2 infection, with indications that rare inborn errors of immunity may play role its pathogenesis. Recent studies suggest genetic predispositions, particularly monogenic forms, could significantly influence the immune responses to MIS-C. We analysed 24 under 12 years old, all whom met criteria provided by World Health Organization, 2020 for MIS-C diagnosis, Paediatric COVID-19 Registry Kuwait...
Anxiety disorders are the second most common mental health in terms of disability-adjusted life years and lost across all age groups. A bidirectional relationship between anxiety diabetes mellitus has been documented. This study aimed to determine prevalence its associated factors among patients with receiving care at public primary clinics Kuwait during first quarter 2024. cross-sectional was conducted 2024 three healthcare centres within Capital Governate City. Adults for longer than six...
Abstract Background/Aims Current childhood fat mass (FM) assessment techniques are not suitable for clinical and population‐level adiposity assessment. A prediction model, which accurately estimates FM using predictor variables of weight, height, age, sex ethnicity, requires validation in Arab populations. We evaluate the model's performance Kuwaiti, Lebanese Moroccan children/adolescents. Methods Data from three cross‐sectional studies on 471 individuals, aged 6–15 years, were obtained with...
Abstract Introduction The COVID‐19 pandemic might have a multifaceted effect on children with type 1 diabetes (T1D), either directly through infection itself or indirectly due to measures implemented by health authorities control the pandemic. Objective To compare data newly diagnosed T1D in Kuwait during pre‐pandemic period. Research Design and Methods We analysed aged 12 years less registered Childhood‐Onset Diabetes electronic Registry (CODeR) Kuwait. Data were incidence rate (IR),...
The incidence of type 1 diabetes mellitus (T1DM) in Kuwait is amongst the highest world. Vitamin D considered to be involved immune modulation and its deficiency contribute autoimmune destruction insulin producing beta cells T1DM patients. has been shown exert effects via a nuclear vitamin receptor (VDR) therefore, VDR gene may candidate for susceptibility. genotypes four polymorphisms were determined 253 Kuwaiti Arab patients 214 healthy controls by PCR-RFLP analysis. Serum concentrations...
Although most neonates with severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection experience only mild disease, its impact on neurodevelopmental outcomes is unknown. This study aimed to assess the 18-month of infants who had SARS-CoV-2 as neonates.
Abstract Genetic variants responsible for Maturity-Onset-Diabetes of the Young (MODY) in Kuwait were investigated. A newly established a National Referral Clinic, Dasman Diabetes Institute (DDI-NRC), assessed forty-five members from 31 suspected MODY families by whole exome sequencing. Thirty-three 45 samples independently sequenced at DDI-NRI, Exeter University, UK ( https://www.diabetesgenes.org/ ) using targeted 21-gene panel approach. Pathogenic mutations GCK, HNF1A, HNF1B, HNF4A, and...
Abstract Aims This study reports the prevalence and characteristics related to development of thyroid autoimmunity among children newly diagnosed with type I diabetes (T1D) during COVID‐19 pandemic in Kuwait. Materials Methods is a prospective observational all under age 14 years T1D We define duration from official declaration first identified positive case on 24 February 2020 until 31 December 2022. For comparison, we use time period directly before pandemic, 1 January 2017 23 2020....
Background: Health related quality of life (HRQOL) has become a field extensive research involving children and adolescents with diabetes. There are no HRQOL instruments designed or adapted for the Arabic culture language. The objectives study to test translated version PedsQLTM 4.0 Generic Core Scales (GCS) 3.0 Diabetes Module (DM) in type 1 diabetes (T1DM) Kuwait analyse their psychometric properties. Methods: After process translation, committee review pre-testing (linguistic validation),...
Continuous subcutaneous insulin infusion (CSII) and multiple daily injections (MDI) are two methods currently used to manage type I diabetes mellitus (T1DM). Here we compare our experiences with CSII MDI in a large cohort of pediatric patients Kuwait.Data on 326 T1DM who were started between 2007 2012 retrospectively compared those MDI. They matched for sex, age at diagnosis, duration, glycemic control, requirement, body mass index (BMI). Data collected baseline every three months included...
Abstract There has recently been a growing interest in examining the role of epigenetic modifications, such as DNA methylation, etiology type 1 diabetes (T1D). This study aimed to delineate differences methylation patterns between T1D-affected and healthy individuals by genome-wide from three Arab families Kuwait with mono-/dizygotic twins non-twinned siblings. Bisulfite sequencing peripheral blood affected each was performed. Methylation profiles were compared those Principal component...
This study aimed to provide a global insight into initiatives in type 1 diabetes care driven by the COVID-19 pandemic and associations with glycemic outcomes.An online questionnaire regarding before during was sent all centers (n = 97, 66,985 youth diabetes) active SWEET registry. Eighty-two responded, 70 (42,798 had available data (from individuals duration >3 months, aged ≤21 years) for 4 years from 2018 2021. Statistical models were adjusted, among others, technology use.Sixty-five...
Background: Type 2 Diabetes (T2D) in children and adolescents has become an important public health concern due to the increase childhood obesity worldwide. The urgency address T2D is evident as are at a higher risk of complications prolonged disease duration. We aimed estimate incidence rate (IR) Kuwaiti aged 14 years younger between 2011-2013 describe their clinical characteristics time diagnosis. Material Methods: All newly diagnosed patients were registered through Childhood-Onset...
Mucopolysaccharidosis type I (MPS I) is an autosomal recessive lysosomal storage disorder characterized by deficient or absent α -L-iduronidase (IDUA) enzyme activity due to pathogenic variants in the IDUA gene. Early treatment with hematopoietic stem cell transplantation and/or replacement therapy associated improved outcomes this progressive multisystem disease. The diagnosis usually delayed late presentation and non-specific symptoms, which result high morbidity mortality. incidence of...