A5011988774- Diabetes Treatment and Management
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Metabolism, Diabetes, and Cancer
- Vitamin D Research Studies
- Genetic Associations and Epidemiology
- Liver Disease Diagnosis and Treatment
- Cardiovascular Function and Risk Factors
- Diabetic Foot Ulcer Assessment and Management
- Pain Mechanisms and Treatments
- Ocular Surface and Contact Lens
- Pancreatic function and diabetes
- Genomic variations and chromosomal abnormalities
- Genomics and Rare Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Pharmacology and Obesity Treatment
- Retinal Diseases and Treatments
- Cardiac Valve Diseases and Treatments
- Bariatric Surgery and Outcomes
- Inflammatory Biomarkers in Disease Prognosis
- Obesity and Health Practices
- Forensic and Genetic Research
- Diet and metabolism studies
- Cardiovascular Disease and Adiposity
Hamad Medical Corporation
2016-2025
Hamad General Hospital
2003-2025
Dasman Diabetes Institute
2025
University of Bahrain
2025
Salmaniya Medical Complex
2025
Mubarak Al Kabeer Hospital
2025
Al Yarmouk University College
2025
Primary HealthCare
2025
Primary Health Care
2025
Farwaniya Hospital
2025
An open question in the history of human migration is identity earliest Eurasian populations that have left contemporary descendants. The Arabian Peninsula was initial site out-of-Africa migrations occurred between 125,000 and 60,000 yr ago, leading to hypothesis first were established on indigenous Arabs are direct descendants these ancient peoples. To assess this hypothesis, we sequenced entire genomes 104 unrelated natives at high coverage, including 56 Arab ancestry. defined a cluster...
Reaching the full potential of precision medicine depends on quality personalized genome interpretation. In order to facilitate in regions Middle East and North Africa (MENA), a population-specific for indigenous Arab population Qatar (QTRG) was constructed by incorporating allele frequency data from sequencing 1,161 Qataris, representing 0.4% population. A total 20.9 million single nucleotide polymorphisms (SNPs) 3.1 indels were observed Qatar, including an average 1.79% novel variants per...
Transcatheter aortic valve replacement (TAVR) is increasingly used for instead of surgical (sAVR). We aimed to examine the impact diabetes on 30-day mortality, readmission and compare outcomes between TAVR sAVR. Data were extracted from Nationwide Readmissions Database 2012 2017. The primary outcome was secondary readmission. study included 110 135 patients who underwent replacement. Of these, 59 466 (54.0%) hospitalised TAVR, 50 669 (46.0%) Diabetes present in 36.4% 29.1% sAVR patients. In...
Background While the cardiovascular risk of hyperglycemia has been thoroughly elucidated in patients with type 2 diabetes (T2DM) hospitalized for myocardial infarction, evidence surrounding acute severe is less well-established. Our study aimed to explore impact diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS), both conditions, on outcomes T2D admitted ST-elevation infarction (STEMI). Methods We used National Readmission Database (2016–2019) extract T2DM STEMI at...
Aims . Much of the diabetes burden is caused by its complications. This cross-sectional study aimed to determine prevalence and risk factors for diabetic microvascular complications (retinopathy, nephropathy, neuropathy) in a high-risk population. Methods We collected information via structured questionnaire directly from patient’s record on 1034 adult type 2 patients who were attending outpatient clinics Qatar. Results The mean age was 55 ± 10 years, duration 12.4 8.9 years. Forty-five...
Introduction To assess the effect of exenatide and pioglitazone or basal-bolus insulin on diabetic peripheral neuropathy (DPN) in patients with poorly controlled type 2 diabetes (T2D). Research design methods This is a substudy Qatar Study, an open-label, randomized trial. 38 subjects T2D were studied at baseline 1-year follow-up 18 control assessed only. A combination (2 mg/week) (30 mg/day) glargine aspart randomly assigned to achieve HbA1c <53 mmol/mol (<7%). DPN was corneal...
This study determined the prevalence and risk factors for diabetic peripheral neuropathy (DPN), painful DPN foot ulceration (DFU) in patients with type 2 diabetes secondary healthcare Qatar, Kuwait Kingdom of Saudi Arabia. Adults aged 18-85 years were randomly enrolled from healthcare, underwent clinical metabolic assessment. was evaluated using vibration perception threshold neuropathic symptoms Diabetic Peripheral Neuropathy Douleur Neuropathique 4 questionnaire. A total 3,021 individuals...
Abstract Background Elevated endothelial microparticles (EMPs) levels are surrogate markers of vascular dysfunction. We analyzed EMPs with apoptotic characteristics and assessed the angiogenic contents in blood patients type 2 diabetes (T2D) according to presence coronary artery disease (CAD). Methods A total 80 participants were recruited equally classified as (1) healthy without T2D, (2) T2D cardiovascular complications, (3) chronic (CAD), (4) acute syndrome (ACS). MPs isolated from...
Exome sequencing of families related individuals has been highly successful in identifying genetic polymorphisms responsible for Mendelian disorders. Here, we demonstrate the value reverse approach, where use exome a sample unrelated to analyze allele frequencies known causal mutations diseases. We sequenced exomes 100 representing three major subgroups Qatari population (Q1 Bedouin, Q2 Persian-South Asian, Q3 African) and identified 37 variants 33 genes with effects on 36 clinically...
The purpose of this review is to summarize the distinct metabolic and pathophysiologic phenotype impaired fasting glucose (IFG) tolerance (IGT) subsequent clinical implications with regard future type 2 diabetes mellitus (T2DM) cardiovascular risk.Both IFG IGT manifest two core defects T2DM, that is, insulin resistance β-cell dysfunction. However, site shape dysfunction differ. These phenotypes explain greater disease (CVD) risk associated an increase in 2-h plasma concentration, compared...
Red cell distribution width (RDW) has emerged as a prognostic marker in patients with cardiovascular diseases. We investigated mortality diabetes included the National Health and Nutrition Examination Survey, relation to baseline RDW. RDW was divided into 4 quartiles (Q1: ≤12.4%, Q2: 12.5%-12.9%, Q3: 13.0%-13.7%, Q4: >13.7%).A total of 3,061 were included: mean age 61 ± 14 years, 50% male, 39% White. Mean 13.2% 1.4%. Compared first quartile (Q1) RDW, Q4 more likely be older, female,...
Abstract Aims Vitamin D measurement is a composite of vitamin 2 (25(OH)D ) and 3 levels, its deficiency associated with the development type diabetes (T2DM) diabetic complications; may be treated supplements. This study was undertaken to determine if levels differed between those without T2DM in this Middle Eastern population, relationship microvascular complications subjects . Methods Four hundred ninety-six Qatari subjects, 274 222 participated study. Plasma total were measured by LC-MS/MS...
Cardiac autonomic neuropathy (CAN) has been suggested to be associated with hypoglycemia and impaired unawareness. We have assessed the relationship between CAN extensive measures of glucose variability (GV) in patients type 1 2 diabetes.Participants diabetes underwent continuous monitoring (CGM) obtain GV extent hyperglycemia cardiovascular reflex testing.Of 40 participants (20 T1DM 20 T2DM) (aged 40.70 ± 13.73 years, duration 14.43 7.35 HbA1c 8.85 1.70%), 23 (57.5%) had CAN. Despite a...
The genetic determinants of low-density lipoprotein cholesterol (LDL-C) levels in blood have been predominantly explored European populations and remain poorly understood Middle Eastern populations. We investigated the architecture LDL-C variation Qatar by conducting a genome-wide association study (GWAS) on serum using whole genome sequencing data 13,701 individuals (discovery; n=5,939, replication; n=7,762) from population-based Biobank (QBB) cohort. replicated 168 previously reported loci...
<h3>Objectives:</h3> To provide insights into the real-world usage of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter 2 inhibitors (SGLT2i) among individuals with type diabetes (T2D) from Bahrain, Kuwait, Qatar who either had established atherosclerotic cardiovascular disease (eASCVD) or were at high risk developing ASCVD. <h3>Methods:</h3> This study 1062 adults diagnosed T2D is a sub-analysis within Prevalence Clinical Management Atherosclerotic...
Objectives . To investigate the efficacy and safety of three most commonly prescribed statins (rosuvastatin, atorvastatin, pravastatin) for managing dyslipidemia among diabetic patients in Qatar. Subjects Methods This retrospective observational population-based study included 350 consecutive diabetes who were diagnosed with any indicated between September 2005 2009. Data was collected by review Pharmacy Database, Electronic Medical Records Database (EMR viewer), Patient's Records....
OBJECTIVE The Qatar Study was designed to examine the efficacy of combination therapy with exenatide plus pioglitazone versus basal/bolus insulin in patients long-standing poorly controlled type 2 diabetes mellitus (T2DM) on metformin a sulfonylurea. RESEARCH DESIGN AND METHODS study randomized 231 (HbA1c &gt;7.5%, 58 mmol/mol) T2DM sulfonylurea receive 1) weekly (combination therapy) or 2) basal prandial (insulin maintain HbA1c &lt;7.0% (53 mmol/mol). RESULTS After mean follow-up 12...
Circulating microparticles (MPs) are major mediators in cardiovascular complications of type 2 diabetes (T2D); however, their contribution to Charcot foot (CF) disease is not known. Here, we purified and assessed the origin, concentration content circulating MPs from 33 individuals: 11 with T2D acute CF, patients equivalent neuropathy non-diabetic controls. First, demonstrated that there were no differences distribution endothelial, platelet origin among 3 groups. However, leukocytes...
The prevalence of type 2 diabetes (T2D) is increasing in the Middle East. However, genetic risk factors for T2D Eastern populations are not known, as majority studies Europeans and Asians.All subjects were ≥3 generation Qataris. Cases with (n = 1,124) controls 590) randomly recruited assigned to 3 known Qatari subpopulations [Bedouin (Q1), Persian/South Asian (Q2) African (Q3)]. Subjects underwent genotyping 37 single nucleotide polymorphisms (SNPs) 29 genes be associated and/or populations,...
Abstract Aims/Introduction This study determined the prevalence and risk factors for diabetic peripheral neuropathy (DPN) painful DPN (pDPN) in patients with type 2 diabetes primary healthcare (PHC) secondary (SHC) Qatar. Materials Methods was a cross‐sectional multicenter study. Adults were randomly enrolled from four PHC centers two SHC Participants underwent assessment of clinical metabolic parameters, pDPN. Results A total 1,386 individuals (297 1,089 SHC) recruited. The (14.8% vs 23.9%,...