A5111972017- Dietary Effects on Health
- Diabetes Treatment and Management
- Diabetes Management and Research
- Pituitary Gland Disorders and Treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Growth Hormone and Insulin-like Growth Factors
- Diabetic Foot Ulcer Assessment and Management
- Metabolism, Diabetes, and Cancer
- Lipid metabolism and disorders
- Pharmacology and Obesity Treatment
- Neuroendocrine Tumor Research Advances
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Gestational Diabetes Research and Management
- Thyroid Disorders and Treatments
- Blood Pressure and Hypertension Studies
- Skin Diseases and Diabetes
- Botulinum Toxin and Related Neurological Disorders
- Neuroblastoma Research and Treatments
- Diabetes Management and Education
- Pain Mechanisms and Treatments
- Peripheral Artery Disease Management
- Vitamin C and Antioxidants Research
- Adrenal Hormones and Disorders
- Lipoproteins and Cardiovascular Health
- Ovarian function and disorders
Hamad Medical Corporation
2018-2025
Hamad General Hospital
2018-2025
Qatar University
2021
Malabar Institute of Medical Sciences
2021
Weill Cornell Medical College in Qatar
2021
Dumfries and Galloway Royal Infirmary
2014
Lincoln County Hospital
2014
University Hospital Ayr
2007-2010
King Faisal Specialist Hospital & Research Centre
2006-2008
Dudley Group NHS Foundation Trust
2006
Vascular disease in type 1 diabetes is a complex and multifactorial process, which probably begins childhood association with the onset of diabetes. To determine possible factors involved, we measured microvascular responses to endothelium-dependent (acetylcholine) endothelium-independent (sodium nitroprusside) vasodilators 56 patients (aged 9-22 years) 22 control subjects.Skin perfusion was at dorsum foot using laser Doppler flowmetry during low-current iontophoresis acetylcholine sodium...
BACKGROUND Hypopituitarism in adults is associated with increased vascular mortality, which has been attributed to GH deficiency. OBJECTIVE To compare the lipid profile and coronary risk predicted by Framingham Heart Study equation GH‐deficient hypopituitary patients healthy age gender‐matched controls. DESIGN A cross‐sectional observational study. METHODS We studied 50 adult‐onset growth hormone deficient (23F, 27M), on appropriate conventional replacement 45 controls (22F, 23M) matched for...
ObjectiveTo develop a machine-based algorithm from clinical and demographic data, physical activity glucose variability to predict hyperglycaemic hypoglycaemic excursions in patients with type 2 diabetes on multiple lowering therapies who fast during Ramadan.Patients methodsThirteen (10 males three females) 3 or more anti-diabetic medications were studied Fitbit-2 pedometer device Freestyle Libre (Abbott Diagnostics) weeks before Ramadan. Several machine learning techniques trained blood...
This study determined the prevalence and risk factors for diabetic peripheral neuropathy (DPN), painful DPN foot ulceration (DFU) in patients with type 2 diabetes secondary healthcare Qatar, Kuwait Kingdom of Saudi Arabia. Adults aged 18-85 years were randomly enrolled from healthcare, underwent clinical metabolic assessment. was evaluated using vibration perception threshold neuropathic symptoms Diabetic Peripheral Neuropathy Douleur Neuropathique 4 questionnaire. A total 3,021 individuals...
Endothelial cell dysfunction is an early feature of vascular disease and oxidative stress may be involved in its pathogenesis.Fifty-one children, adolescents young people with Type 1 diabetes no clinical diabetic angiopathy, mean age+/-SD 16+/-4 years, duration 8+/-5 HbA(1c) 8.5+/-1.6%, 29 age, sex matched normal controls had blood samples assayed for E-selectin, intercellular adhesion molecule-1, von Willebrand Factor, red superoxide dismutase, plasma thiol glutathione.E-selectin ICAM-1...
Adult hypopituitarism is known to be associated with reduced life expectancy related excess vascular events, and endothelial dysfunction present in patients this condition. We studied the relationship between biophysical biochemical markers of dysfunction, including E-selectin, intercellular cell adhesion molecule-1, von Willebrand factor, thrombomodulin 52 adult severe GH deficiency (<2 ng/ml on provocative testing) compared 54 age-, sex-, smoking-matched normal controls. also examined...
Painful diabetic peripheral neuropathy (PDPN) has a significant impact on the patient's quality of life. The prevalence PDPN in Middle East and North Africa region been reported to be almost double that populations UK. We sought determine its associated factors type 2 diabetes mellitus patients attending secondary care Qatar.This was cross-sectional study 1,095 participants with Qatar's two national centers. impaired vibration perception pulp large toes were assessed using Douleur...
Abstract Aims Diabetic neuropathy (DN) is a “Cinderella” complication, particularly in the Middle East. A high prevalence of undiagnosed DN and those at risk diabetic foot ulceration (DFU) major concern. We have determined its factors, DFU, DFU patients with type 2 diabetes mellitus (T2DM) secondary care Qatar. Materials methods Adults T2DM were randomly selected from two National Diabetes Centers was defined by presence neuropathic symptoms vibration perception threshold (VPT) ≥ 15 V....
Abstract A 62-year-old Sudanese female was diagnosed with a nonfunctioning pituitary adenoma in 2006. Despite undergoing 3 transsphenoidal surgeries and radiotherapy, her tumor persisted, causing debilitating symptoms, including headaches visual defects. As last resort, she treated pasireotide, second-generation somatostatin analog broader receptor affinity than first-generation drugs. Over 6 months, the mass stabilized, headaches, disappeared. This case demonstrates potential new...
Metformin may lead to B12 deficiency and neuropathy. There are no published data on the prevalence of Metformin-related neuropathy in Arabian Gulf.Determine whether intake is associated with diabetic peripheral (DPN) painful neuropathy.Patients type 2 diabetes mellitus (T2DM) (n = 362) attending outpatient clinics at HMC underwent assessment levels, DN4 questionnaire, vibration perception threshold (VPT).Comparing non-Metformin users there were differences VPT, or DN4. The (B12 <133 pmol/l)...
Abstract Aims/Introduction This study determined the prevalence and risk factors for diabetic peripheral neuropathy (DPN) painful DPN (pDPN) in patients with type 2 diabetes primary healthcare (PHC) secondary (SHC) Qatar. Materials Methods was a cross‐sectional multicenter study. Adults were randomly enrolled from four PHC centers two SHC Participants underwent assessment of clinical metabolic parameters, pDPN. Results A total 1,386 individuals (297 1,089 SHC) recruited. The (14.8% vs 23.9%,...
OBJECTIVE: To examine the influence of puberty on endothelial dysfunction and oxidative stress in children young people with type 1 diabetes. RESEARCH DESIGN AND METHODS: There were 51 patients diabetes, including 12 prepubertal children, 16 adolescents, 23 adults who had no clinical diabetic angiopathy, studied; none microalbuminuria. The three groups matched for glycemic control, systolic diastolic blood pressures cholesterol levels not significantly different between groups....
The major cause of morbidity and mortality in pa tients with type 1 diabetes mellitus is vascular disease the death rate this group patients can be up to six times that general population. Elevated levels blood glucose endothelial cell damage, markers dam age such as von Willebrand factor (vWF) thrombomodulin (TM) have been reported increase adult diabetic patients. Growth factors are strongly linked smooth muscle pro liferation contributes significantly occlusive process it has shown growth...
Acromegaly is a chronic hormonal disorder caused by excessive GH secretion. In addition to physiological symptoms, it often accompanied debilitating headaches. Although effective treatment options exist, achieving complete symptom control and disease management can still be challenging. This case report chronicles the clinical journey of 38-year-old male diagnosed with acromegaly in 2013. Despite prior interventions, including surgery first-generation somatostatin analogues, severe frequent...
Summary objective Adult GH deficiency (GHD) is linked to endothelial dysfunction and vascular disease. We examined the effect of 12 months therapy on function, C‐reactive protein (CRP) coronary risk. design Open‐design intervention study. patients Fourteen GH‐deficient (nonsmokers, without diabetes, hypertension or disease) studied before, 6 after therapy. measurements Flow‐mediated dilatation (FMD), carotid intima–media thickness (IMT) thrombomodulin (TM), E‐selectin, CRP, lipid profile,...
The aim of this study was to assess the prevalence and effects presence metabolic syndrome in patients with type 1 diabetes. Retrospective analysis data from a one year period attending annual review clinic undertaken. Body weight, height blood pressure were measured along assessment micro-/macro-vascular complications. HbA1c, urea, cholesterol, triglyceride, urinary albumin: creatinine ratios also measured. Patients divided into those without syndrome. Data 365 diabetic analysed. Hundred...
We report a 73‐year‐old woman with rapidly developing symptoms and signs of Cushing’s syndrome high urinary free cortisol. She was virilized hirsute testosterone levels which became exceptionally high. ACTH suppressed CT scan the adrenals pelvis showed no abnormality. Ultrasound scanning enlargement left ovary. Venous catheter studies suggested ovarian source. A 2‐cm diameter lipid cell tumour removed from ovary laparoscopically. Histology initially benign, clinical biochemical cure...
Adult hypopituitarism is known to be associated with reduced life expectancy related excess vascular events, and endothelial dysfunction present in patients this condition. We studied the relationship between biophysical biochemical markers of dysfunction, including E-selectin, intercellular cell adhesion molecule-1, von Willebrand factor, thrombomodulin 52 adult severe GH deficiency (<2 ng/ml on provocative testing) compared 54 age-, sex-, smoking-matched normal controls. also examined...