A5033193705- Diabetic Foot Ulcer Assessment and Management
- Botulinum Toxin and Related Neurological Disorders
- Wound Healing and Treatments
- Pressure Ulcer Prevention and Management
- Balance, Gait, and Falls Prevention
- Pain Mechanisms and Treatments
- Genetics and Physical Performance
- Mesenchymal stem cell research
- Sports Performance and Training
- Folate and B Vitamins Research
- Sports injuries and prevention
- Ocular Surface and Contact Lens
- Bone and Joint Diseases
- Transcranial Magnetic Stimulation Studies
- Skin Diseases and Diabetes
- Stroke Rehabilitation and Recovery
- Laser Applications in Dentistry and Medicine
- Exercise and Physiological Responses
- Infrared Thermography in Medicine
- Trace Elements in Health
- Atrial Fibrillation Management and Outcomes
- Spectroscopy Techniques in Biomedical and Chemical Research
- Corneal Surgery and Treatments
- Cardiovascular Disease and Adiposity
- Drug Transport and Resistance Mechanisms
Hamad Medical Corporation
2012-2022
RMIT University
2021
UNSW Sydney
2019
Hamad General Hospital
2015-2018
University of Arizona
2012-2014
Qatar Airways (Qatar)
2013
Rosalind Franklin University of Medicine and Science
2012
The University of Texas Southwestern Medical Center
2012
Louisiana State University
1973-1974
University Medical Center New Orleans
1973-1974
Abstract Wound moisture is known to be a key parameter ensure optimum healing conditions in wound care. This study tests the content of wounds normal practice order observe condition at point dressing change. also first large‐scale observational that investigates status The WoundSense sensor commercially available which sits directly on find without disturbing or removing dressing. results show 588 changes recorded, 44·9% were made when reading was zone. Of 30 patients recruited for this...
<b><i>Background:</i></b> Individuals with diabetic peripheral neuropathy (DPN) have deficits in sensory and motor skills leading to inadequate proprioceptive feedback, impaired postural balance higher fall risk. <b><i>Objective:</i></b> This study investigated the effect of sensor-based interactive training on stability daily physical activity older adults diabetes. <b><i>Methods:</i></b> Thirty-nine DPN were enrolled...
This study aimed to validate a smart-textile based on fiber-optics for simultaneous measurement of plantar temperature, pressure, and joint angles in patients with diabetic peripheral neuropathy (DPN).After in-vitro validation the laboratory, 33 eligible subjects DPN were recruited (age: 58 ± 8 years, BMI: 31.5 kg/m2) assessing pressure temperature during habitual gait-speed clinical-setting. All participants asked walk at their speed while wearing pair sensorized socks made from highly...
Objective: The objective was to report patterns of physical activity and their relationship wound healing success in patients with diabetic foot ulcers protected removable or irremovable offloading devices. Methods: Forty-nine people were randomized wear either a cast walker (RCW) an instant total contact (iTCC). Primary outcome measures included change size, activities including position (ie, sitting, standing, lying) locomotion (speed, steps, etc). Outcomes parameters assessed on weekly...
Objective: People with diabetic peripheral neuropathy (DPN) often exhibit deteriorations in motor-performance mainly due to lack of plantar-sensation. The study explored effectiveness plantar electrical-stimulation therapy enhance among people DPN. Design and methods: Using a double-blinded model, 28 volunteers DPN (age: 57.8 ± 10.2 years) were recruited randomized either intervention (IG: n = 17) or control (CG: 11) group. Both groups received identical plantar-stimulation devices for six...
Objective. Asymmetric plantar temperature differences secondary to inflammation is a hallmark for the diagnosis and treatment response of Charcot foot syndrome. However, little attention has been given activity. We examined dynamic changes in (PT) as function graduated walking activity quantify thermal responses during first 200 steps. Methods. Fifteen individuals with Acute neuroarthropathy (CN) 17 non-CN participants type 2 diabetes peripheral neuropathy were recruited. All walked two...
Background: Individuals with diabetic peripheral neuropathy frequently experience concomitant impaired proprioception and postural instability. Conventional exercise training has been demonstrated to be effective in improving balance but does not incorporate visual feedback targeting joint perception, which is an integral mechanism that helps compensate for neuropathy. Methods: This prospective cohort study recruited 29 participants (mean ± SD: age, 57 10 years; body mass index [calculated...
Circulating microparticles (MPs) are major mediators in cardiovascular complications of type 2 diabetes (T2D); however, their contribution to Charcot foot (CF) disease is not known. Here, we purified and assessed the origin, concentration content circulating MPs from 33 individuals: 11 with T2D acute CF, patients equivalent neuropathy non-diabetic controls. First, demonstrated that there were no differences distribution endothelial, platelet origin among 3 groups. However, leukocytes...
<b><i>Background:</i></b> Individuals with diabetes have a higher risk of falls and fall-related injuries. People often develop peripheral neuropathy (DPN) as well nerve damage throughout the body. In particular, reduced lower extremity proprioception due to DPN may cause misjudgment foot position thus increase fall. <b><i>Objective:</i></b> An innovative virtual obstacle-crossing paradigm using wearable sensors was developed in an attempt...
Background: Gait-related fall risk is the leading cause of mortality among patients with diabetes, especially those older than 65 years. Deterioration in balance and loss protective sensation lower extremities contribute significantly to diabetic peripheral neuropathy (DPN). This study aimed explore impact foot ulcer on gait. Methods: We recruited 39 participants (age, 56.9 ± 8.2 years; body mass index, 29.6.3 4.7 kg/m 2 ), including 15 DPN without ulcers, 16 8 healthy aged-matched controls....
The aim of the present study was to identify extent small fiber neuropathy in diabetic patients with Charcot neuroarthropathy (CN).A total 20 CN were compared age- and diabetes duration-matched type 2 age-matched control participants. All underwent corneal confocal microscopy quantification nerve morphology assessment for vibration perception threshold, a subset sudomotor function neuropathic pain.In participants, there significant reduction density (14.94 ± 8.23 vs 23.86 7.71, P = 0.004...
Aim: Charcot foot (CF) is a rare complication of Type 2 diabetes (T2D). Materials & methods: We assessed circulating miRNAs in 17 patients with T2D and acute CF (G1), (G2) equivalent neuropathy without (G3) using the high-throughput miRNA expression profiling. Results: 51 significantly deregulated were identified G1 versus G2, 37 G3 64 G2 G3. Furthermore, we demonstrated that 16 differentially expressed between could be involved osteoclastic differentiation. Among them, eight are key factors...
Aim: To assess whether DNA methylation of monocytes play a role in the development acute diabetic Charcot foot (CF). Patients & methods: We studied whole methylome (WM) circulating 18 patients with Type 2 diabetes (T2D) and CF, T2D equivalent neuropathy without neuropathy, using enhanced reduced representation bisulfite sequencing technique. Results conclusion: WM analysis demonstrated that CF are differentially methylated compared non-CF monocytes, both CpG-site gene-mapped approaches....
An alteration in circulating miRNAs may have important diagnostic and therapeutic relevance diabetic neuropathy. Patients with type 2 diabetes mellitus (T2DM) underwent an assessment of neuropathic symptoms using Douleur Neuropathique 4 (DN4), the vibration perception threshold (VPT) a Neurothesiometer, sudomotor function Sudoscan, corneal nerve morphology confocal microscopy (CCM) high-throughput miRNA expression profiling. T2DM, (n = 9) without 7) significant loss were comparable age,...
Background: Undetected repeated foot loading and temperature changes during walking in diabetic patients with peripheral neuropathy significantly increases risk of ulceration. Early detection inflammation due to pressure from has shown be a potentially effective strategy prevention ulcers. Therefore, clinically feasible assessment these is vital measure pre-ulcerative predict DFUs. The current study aimed validate effectiveness an innovative fiber optics embedded smart textile for...
Background & Objectives: Charcot neuroarthropathy (CN) is a devastating complication of diabetes. It has two-fold higher rate major amputation compared to those without CN. Unfortunately, date, there no pathological marker or diagnostic criterion for it and diagnosis relies on pattern recognition clinical intuition. Not surprisingly, the can be missed up 95% time average delay been estimated at almost 7 months. Recent studies reported asymmetric plantar temperature differences secondary...
Background: People with diabetes-related peripheral neuropathy (DPN) frequently suffer from concomitant postural instability that can lead to falls, fractures, depression, anxiety, and decreased quality of life. Exercise has been demonstrated be effective in improving balance. However, high demands conventional balance programs might overtax DPN patients' ability perform exercises correctly. This turn reduce motivation or increase risk diabetic foot ulcers. In addition, training regimes do...
Background: Diabetic peripheral neuropathy (DPN) is one of the most common complications diabetes that affects nerve functions and may occur in 25% patients with 10 or more years up to 50% 20 diabetes. Patients DPN experience a high incidence injuries while walking have low level perceived safety. In certain cases impaired judgment - mainly due proprioceptive feedback can cause obstacle collision leading falls injuries. The subtle early findings are indicative postural instability difficult...