Binding and transport characteristics for uptake of taurocholic acid by isolated rat liver cells were studied. 1. An adsorption taurocholate to the cell surface is terminated in less than 15 s. A Ks 0.55 mM a total binding capacity 3.8 nmol/mg protein determined. 2. The rate follows Michaelis-Menten kinetics with Km = 19 muM V 1.7 min. 3. There broad pH optimum between 6.5 -- 8.0. 4. activation energy amounts 29 kcal/mol. At high concentration an unusual upward bend observed Arrhenius plot....

<b>Background:</b> Deficits in attention-related cognitive performance measured as dual-task represent early markers of dementia and are associated with motor deficits increased risk falling. The purpose this study was to examine the effect a specific training patients mild moderate dementia. <b>Methods:</b> Sixty-one geriatric confirmed took part 12-week randomized, controlled trial. Subjects intervention group (IG) underwent dual-task–based exercise training. control (CG) performed...

Objectives To determine whether a specific, standardized training regimen can improve muscle strength and physical functioning in people with dementia. Design Double‐blinded, randomized, controlled trial 3‐month intervention follow‐up period 2006 to 2009. Setting Outpatient geriatric rehabilitation. Participants Individuals confirmed mild moderate dementia, no severe somatic or psychological disease, ability walk 10 m. Most participants were still living independently without supportive...

Frailty is a geriatric syndrome resulting from age-related cumulative decline across multiple physiologic systems, impaired homeostatic reserve, and reduced capacity to resist stress. Based on recent estimates, 10% of community-dwelling older individuals are frail another 41.6% prefrail. Frail elders account for the highest health care costs in industrialized nations. Impaired physical function major indicator frailty, functional performance tests useful identification frailty. Objective...

&lt;i&gt;Background:&lt;/i&gt; Measures of fear falling have not yet been validated in patients with dementia, leaving a methodological gap that limits research population at high risk and fall-related consequences. &lt;i&gt;Objective:&lt;/i&gt; The objectives this study are to determine: (1) the validity 7-item Short Falls Efficacy Scale International (Short FES-I) geriatric without cognitive impairment, (2) sensitivity change 10-item (FES), 16-item FES-I dementia....

Cancer patients with chemotherapy-induced peripheral neuropathy (CIPN) have deficits in sensory and motor skills leading to inappropriate proprioceptive feedback, impaired postural control, fall risk. Balance training programs specifically developed for CIPN are lacking.This pilot study investigated the effect of an interactive adaptation balance program based on wearable sensors improving older cancer CIPN.Twenty-two (age: 70.3 ± 8.7 years) objectively confirmed [vibration perception...

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; Individuals with diabetic peripheral neuropathy (DPN) have deficits in sensory and motor skills leading to inadequate proprioceptive feedback, impaired postural balance higher fall risk. &lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; This study investigated the effect of sensor-based interactive training on stability daily physical activity older adults diabetes. &lt;b&gt;&lt;i&gt;Methods:&lt;/i&gt;&lt;/b&gt; Thirty-nine DPN were enrolled...

Highlights•We examined the dynamics of motor control locomotion in challenging settings•We extracted muscle synergies (motor modules and primitives) from electromyography•The time-dependent primitives were modified by perturbations•Primitives wider, less unstable, complex presence perturbationsSummaryIs movement stable when we walk or run settings? Intuitively, one might answer that it is, given externally (e.g., rough terrain) internally age-related impairments) makes our movements more...

Uptake of the hepatodiagnostic dye bromosulfophthalein into isolated hepatocytes was studied with special regard to kinetics transport. The following results were obtained. uptake follows Michaelis‐Menten only at low substrate concentrations an apparent K m = 7 ± 2 μM and V 2.6 1.7 nmol × mg protein −1 min −1′ . At higher a second mechanism is observed as indicated by deviation from linearity in Lineweaver‐Burk plot. activation energy found be 11 kcal/mol 10 bromosulfophthalein. independent...

Wearable sensor technology can accurately measure body motion and provide incentive feedback during exercising. The aim of this pilot study was to evaluate the effectiveness user experience a balance training program in older adults integrating data from wearable sensors into human-computer interface designed for interactive training.Senior living community residents (mean age 84.6) with confirmed fall risk were randomized an intervention (IG, n = 17) or control group (CG, 16). IG underwent...

Preventing and rehabilitating gait disorders in people with dementia during early disease stage is of high importance for staying independent ambulating safely. However, the evidence gathered randomized controlled trials (RCTs) on effectiveness exercise training improving spatio-temporal parameters scarce. The aim present study was to determine whether a specific, standardized regimen can improve characteristics dementia. Sixty-one individuals (mean age: 81.9 years) confirmed mild moderate...

&lt;b&gt;&lt;i&gt;Background:&lt;/i&gt;&lt;/b&gt; There is a need for simple clinical tools that can objectively assess the fall risk in people with dementia. Wearable sensors seem to have potential prediction; however, there has been limited work performed this important area. &lt;b&gt;&lt;i&gt;Objective:&lt;/i&gt;&lt;/b&gt; To explore validity of sensor-derived physical activity (PA) parameters predicting future falls compare sensor-based assessment conventional measures....

Some individuals with mild cognitive impairment (MCI) experience not only deficits but also a decline in motor function, including postural balance. This pilot study sought to estimate the feasibility, user experience, and effects of novel sensor-based balance training program. Patients amnestic MCI (mean age 78.2 yr) were randomized an intervention group (IG, n = 12) or control (CG, 10). The IG underwent (4 wk, twice week) that included weight shifting virtual obstacle crossing. Real-time...

Most falls occur after a loss of balance following an unexpected perturbation such as slip or trip. Greater understanding how humans control and maintain stability during perturbed walking may help to develop appropriate fall prevention programs. The aim this study was examine changes in spatiotemporal gait parameters response sudden mechanical perturbations medio-lateral (ML) anterior-posterior (AP) direction treadmill walking. Moreover, we aimed evaluate which are most representative...

Research on foot problems and frailty is sparse could advance using wearable sensor-based measures of gait, balance, physical activity (PA). This study examined the effect likelihood falls, syndrome, motor performance, PA in community-dwelling older adults.Arizona Frailty Cohort Study participants (community-dwelling adults aged ≥65 years without baseline cognitive deficit, severe movement disorders, or recent stroke) underwent Fried assessment. Gait, balance (bipedal eyes open closed),...