A5057626318- Fibroblast Growth Factor Research
- CRISPR and Genetic Engineering
- Telomeres, Telomerase, and Senescence
- Renal and related cancers
- Urological Disorders and Treatments
- Birth, Development, and Health
- Endometrial and Cervical Cancer Treatments
- Sarcoma Diagnosis and Treatment
- Hippo pathway signaling and YAP/TAZ
- Autophagy in Disease and Therapy
- Uterine Myomas and Treatments
- Fungal and yeast genetics research
- Epigenetics and DNA Methylation
- Kruppel-like factors research
- Microbial Metabolic Engineering and Bioproduction
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Genetic Syndromes and Imprinting
- Viral Infectious Diseases and Gene Expression in Insects
- Congenital Diaphragmatic Hernia Studies
- Genetics, Aging, and Longevity in Model Organisms
- Bioeconomy and Sustainability Development
- NF-κB Signaling Pathways
- Plant Molecular Biology Research
Universitat de Lleida
2017-2024
Biomedical Research Institute of Lleida
2017-2024
Oncogenesis Stress Signaling
2024
National Institute on Aging
2022-2023
Institut thématique Génétique, génomique et bioinformatique
2023
Institute on Aging
2022-2023
National Institutes of Health
2022-2023
Hospital Universitari Arnau de Vilanova
2023
Evidence is accumulating that the earliest stages of DNA damage response can direct cells toward senescence instead other cell fates. In particular, tightly regulated signaling through Mitogen-Activated Protein Kinases (MAPKs) in early lead to a sustained pro-survival program and suppress pro-apoptotic program. Importantly, an epithelial-to-mesenchymal Transition (EMT)-like appears essential for preventing apoptosis favoring following damage. this review, we discuss how MAPKs might influence...
Abstract Genes of the Sprouty family (Spry1-4) restrain signaling by certain receptor tyrosine kinases. Consequently, these genes participate in several developmental processes and function as tumor suppressors adult life. Despite important roles, biology this still remains obscure. Here we show that proteins are general mediators cellular senescence. Induction senescence triggers vitro correlates with upregulation protein levels. More importantly, overexpression is sufficient to cause...
Phosphatase and TENsin homolog (Pten) p53 are two of the most frequently mutated tumor suppressor genes in endometrial cancer. However, functional consequences histopathological manifestation concomitant Pten loss function alterations development cancer is still controversial. Here, it demonstrated that simultaneous deletion sufficient to cause epithelial mesenchymal transition phenotype organoids. By a novel intravaginal delivery method using HIV1 trans-activator transcription cell...
Significance Statement Sprouty1 is a critical regulator of genitourinary development that ensures only one kidney forms on each side the embryo. The molecular mechanisms uses to do this are largely unknown. authors show removing single tyrosine from in mice enough inactivate its function during development. Knockin lacking develop supernumerary kidneys, megaureter, and vesicoureteral reflux, same defects seen knockout mice. These findings shed light elusive action Sprouty proteins provide...
The Wolffian ducts (WD) are paired epithelial tubules central to the development of mammalian genitourinary tract. Outgrowths from WD known as ureteric buds (UB) generate collecting kidney. Later during development, caudal portion will form vas deferens, epididymis and seminal vesicle in males, degenerate females. While genetic pathways controlling UB firmly established, less is about those governing portions UB. Sprouty proteins inhibitors receptor tyrosine kinase (RTK) signaling vivo. We...
Genes of the Sprouty family (Spry1-4) are feedback inhibitors receptor tyrosine kinases, especially Ret and FGF receptors. As such, they play distinct overlapping roles in embryo morphogenesis considered to be tumor suppressors adult life. Genetic experiments mice have defined great detail role these genes during embryonic development, however their function is less clearly established. Here we generate adult-onset, whole body Spry1/2/4 triple knockout mice. Tumor incidence mutant comparable...
ABSTRACT Genes of the Sprouty family (Spry1-4) are feedback inhibitors receptor tyrosine kinases, especially Ret and FGF receptors. As such, they play distinct overlapping roles in embryo morphogenesis considered to be tumor suppressors adult life. Genetic experiments mice have defined great detail role these genes during embryonic development, however their function is less clearly established. Here we generate adult-onset, whole body Spry1/2/4 triple knockout mice. Tumor incidence mutant...
Abstract Sublethal cell damage can trigger a complex adaptive program known as senescence, characterized by growth arrest, resistance to apoptosis, and senescence-associated secretory phenotype (SASP). As senescent cells accumulating in aging organs are linked many age-associated diseases, senotherapeutic strategies actively sought eliminate them. Here, whole-genome CRISPR knockout screen revealed that proteins the YAP-TEAD pathway influenced viability. Accordingly, treating with drug...
ABSTRACT Pten and p53 are two of the most frequently mutated tumor suppressor genes in endometrial cancer. However, functional consequences histopathological manifestation concomitant loss function alterations development cancer is still controversial. Here, we demonstrate that simultaneous deletion sufficient to cause epithelial mesenchymal transition phenotype organoids. By a novel TAT-fused Cre intravaginal delivery method, achieved local ablation both specifically uterus. These mice...
Abstract Microorganisms evolved adaptive responses that enable them to survive stressful challenges in ever changing environments by adjusting metabolism through the modulation of gene expression, protein levels and activity, flow metabolites. More frequent allow natural selection ampler opportunities select from a larger number phenotypes are compatible with survival. Understanding causal relationships between physiological metabolic requirements needed for cellular stress adaptation...
ABSTRACT The Wolffian Ducts (WD) are paired epithelial tubules central to the development of mammalian genitourinary tract. Outgrowths from WD known as ureteric buds (UB) generate collecting ducts kidney. Later during development, caudal portion will form vas deferens, epididymis and seminal vesicle in males, degenerate females. While genetic pathways controlling UB firmly established, less is about those governing portions UB. Sprouty proteins inhibitors receptor tyrosine kinase (RTK)...
ABSTRACT Sublethal cell damage can trigger a complex adaptive program known as senescence, characterized by growth arrest, resistance to apoptosis, and senescence-associated secretory phenotype (SASP). As senescent cells accumulating in aging organs are linked many age-associated diseases, senotherapeutic strategies actively sought eliminate them. Here, whole-genome CRISPR knockout screen revealed that proteins the YAP-TEAD pathway influenced viability. Accordingly, treating with drug...