A5036501600- Bone health and treatments
- SARS-CoV-2 and COVID-19 Research
- CRISPR and Genetic Engineering
- Advanced Image Processing Techniques
- Bone Metabolism and Diseases
- RNA and protein synthesis mechanisms
- Advanced Vision and Imaging
- Image Processing Techniques and Applications
- vaccines and immunoinformatics approaches
- Mitochondrial Function and Pathology
- Bacterial Genetics and Biotechnology
- Glycosylation and Glycoproteins Research
- COVID-19 Clinical Research Studies
- Parathyroid Disorders and Treatments
- Bone health and osteoporosis research
- Metabolism, Diabetes, and Cancer
- DNA and Nucleic Acid Chemistry
- Multimodal Machine Learning Applications
- Image Enhancement Techniques
- Reinforcement Learning in Robotics
- Toxin Mechanisms and Immunotoxins
- MicroRNA in disease regulation
- Genetic Syndromes and Imprinting
- Clostridium difficile and Clostridium perfringens research
- ATP Synthase and ATPases Research
Korea University
2024-2025
Harvard University
2024
Massachusetts General Hospital
2024
Hyundai Motors (South Korea)
2023
Yonsei University
2020-2023
University of Toronto
2019-2022
Donnelly College
2021
Seoul National University
2012-2019
Extracellular vesicles (EVs) are membrane-enclosed particles secreted by a variety of cell types. These encapsulate diverse range molecules, including proteins, nucleic acids, lipids, metabolites, and even organelles derived from their parental cells. While EVs have emerged as crucial mediators intercellular communication, they also hold immense potential both biomarkers therapeutic agents for numerous diseases. A thorough understanding EV biogenesis is the development EV-based diagnostic...
Recent approaches for low-light image enhancement achieve excellent performance through supervised learning based on convolutional neural networks. However, it is still challenging to collect a large amount of low-/normal-light pairs in real environments training the In this letter, we propose an unsupervised approach single using bright channel prior (BCP) that brightest pixel small patch likely be close 1. An loss function defined with pseudo ground-truth generated BCP. network, consisting...
Recent works attempt to integrate the non-local operation with CNNs or Transformer, achieving remarkable performance in image restoration tasks. The global similarity, however, has problems of lack locality and high computational complexity that is quadratic an input resolution. local attention mechanism alleviates these issues by introducing inductive bias convolution-like operators. However, focusing only on adjacent positions, suffers from insufficient receptive field for restoration. In...
Abstract The world is facing a global pandemic of COVID-19 caused by the SARS-CoV-2 coronavirus. Here we describe collection codon-optimized coding sequences for cloned into Gateway-compatible entry vectors, which enable rapid transfer variety expression and tagging vectors. freely available. We hope that widespread availability this resource will many subsequent molecular studies to better understand viral life cycle how block it.
Abstract Osteoporosis, characterized by reduced bone density and strength, increases fracture risk, pain, limits mobility. Established therapies of Parathyroid hormone (PTH) analogs effectively promote formation reduce fractures in severe osteoporosis, their use is limited potential adverse effects. In the pursuit safer osteoporosis treatments, we investigated R25C PTH, a PTH variant wherein native arginine at position 25 substituted cysteine. These studies were prompted our finding high...
Osteoporosis, characterized by reduced bone density and strength, increases fracture risk, pain, limits mobility. Established therapies of Parathyroid hormone (PTH) analogs effectively promote formation reduce fractures in severe osteoporosis, their use is limited potential adverse effects. In the pursuit safer osteoporosis treatments, we investigated R25C PTH, a PTH variant wherein native arginine at position 25 substituted cysteine. These studies were prompted our finding high mineral...
Osteoporosis, characterized by reduced bone density and strength, increases fracture risk, pain, limits mobility. Established therapies of Parathyroid hormone (PTH) analogs effectively promote formation reduce fractures in severe osteoporosis, their use is limited potential adverse effects. In the pursuit safer osteoporosis treatments, we investigated R25C PTH, a PTH variant wherein native arginine at position 25 substituted cysteine. These studies were prompted our finding high mineral...
Abstract Since the emergence of SARS-CoV-2 in humans, novel variants have evolved to become dominant circulating lineages. These include D614G (B.1 lineage), Alpha (B.1.1.7), Gamma (P.1), Delta (B.1.617.2), and Omicron BA.1 (B.1.1.529) BA.2 (B.1.1.529.2) viruses. Here, we compared viral replication, pathogenesis, transmissibility these variants. Replication kinetics innate immune response against viruses were tested ex vivo human nasal epithelial cells (HNEC) induced pluripotent stem...
Osteoporosis, characterized by reduced bone density and strength, increases fracture risk, pain, limits mobility. Established therapies of Parathyroid hormone (PTH) analogs effectively promote formation reduce fractures in severe osteoporosis, but their use is limited potential adverse effects. In the pursuit safer osteoporosis treatments, we investigated R25C PTH, a PTH variant wherein native arginine at position 25 substituted cysteine. These studies were prompted our finding high mineral...
Osteoporosis, characterized by reduced bone density and strength, increases fracture risk, pain, limits mobility. Established therapies of parathyroid hormone (PTH) analogs effectively promote formation reduce fractures in severe osteoporosis, but their use is limited potential adverse effects. In the pursuit safer osteoporosis treatments, we investigated R25C PTH, a PTH variant wherein native arginine at position 25 substituted cysteine. These studies were prompted our finding high mineral...
SARS-CoV-2 depends on host cell components for infection and replication. Identification of virus-host dependencies offers an effective way to elucidate mechanisms involved in viral If druggable, factor may present attractive strategy anti-viral therapy. In this study, we performed genome wide CRISPR knockout screens Vero E6 cells four human lines including Calu-3, UM-UC-4, HEK-293 HuH-7 identify genetic regulators infection. Our findings identified only ACE2, the cognate entry receptor, as...
Self-supervised monocular depth estimation has become an appealing solution to the lack of ground truth labels, but its reconstruction loss often produces over-smoothed results across object boundaries and is incapable handling occlusion explicitly. In this paper, we propose a new approach leverage pseudo maps stereo images generated from self-supervised matching methods. The confidence map estimated mitigate performance degeneration by inaccurate maps. To cope with prediction error itself,...
The TIM23 complex mediates membrane insertion of presequence‐containing mitochondrial proteins via a stop‐transfer mechanism. Stop‐transfer signals consist hydrophobic transmembrane segments and flanking charges. Mgr2 functions as lateral gatekeeper the complex. However, it remains elusive which features are discriminated by Mgr2. To determine effects on TIM23‐mediated pathway, we measured model varied hydrophobicity charges in Mgr2‐deletion or ‐overexpression yeast strains. We found that...
Numerous image restoration approaches have been proposed based on attention mechanism, achieving superior performance to convolutional neural networks (CNNs) counterparts. However, they do not leverage the model in a form fully suited tasks. In this paper, we propose an network with novel called cross-scale <italic xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">k</i> -NN Transformer (CS-KiT), that effectively considers several factors such as...
The evolutionarily conserved Sec61 translocon mediates the translocation and membrane insertion of proteins. For integration proteins into membrane, opens laterally to lipid bilayer. Previous studies suggest that lateral opening channel is mediated by helices TM2b TM7 a pore-forming subunit translocon. To map key residues in yeast modulate gating activity, we performed alanine scanning vivo site-directed photocross-linking experiments. Alanine identified two groups critical gate, one group...
Recent vision-based reinforcement learning (RL) methods have found extracting high-level features from raw pixels with self-supervised to be effective in policies. However, these focus on global representations of images, and disregard local spatial structures present the consecutively stacked frames. In this paper, we propose a novel approach, termed Paired Similarity Representation Learning (PSRL) for effectively encoding an unsupervised manner. Given input frames, latent volumes are first...