A5017942308- Vestibular and auditory disorders
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Hearing, Cochlea, Tinnitus, Genetics
- Neuroscience and Neural Engineering
- Advanced Control Systems Optimization
- Algorithms and Data Compression
- Neuroscience of respiration and sleep
- EEG and Brain-Computer Interfaces
- Process Optimization and Integration
- Innovative Approaches in Technology and Social Development
- Fault Detection and Control Systems
- Control Systems and Identification
- Information Systems Theories and Implementation
- Neural Networks and Applications
- Data Management and Algorithms
- Stability and Control of Uncertain Systems
- Data Mining Algorithms and Applications
- Target Tracking and Data Fusion in Sensor Networks
- Advanced Database Systems and Queries
- Green IT and Sustainability
- Muscle activation and electromyography studies
- Psychiatric care and mental health services
- Motor Control and Adaptation
- Environmental Conservation and Management
Lund University
2013-2024
Chalmers University of Technology
2016-2022
Technical University of Munich
2022
Helsingborgs lasarett
2019-2021
Stockholm County Council
2017
Uppsala University
2010-2016
Swedish University of Agricultural Sciences
2009
Luleå University of Technology
2004-2007
Volvo (Sweden)
2007
In-Q-Tel
2007
Associative learning in the cerebellum underlies motor memories and probably also cognitive associations. Pavlovian eyeblink conditioning, a widely used experimental model of such learning, depends on cerebellum, but memory locus within as well underlying mechanisms have remained controversial. To date, crucial information how cerebellar Purkinje cells change their activity during has been ambiguous contradictory, there is no at all about they behave extinction reacquisition. We now tracked...
Synaptic gain control and information storage in neural networks are mediated by alterations synaptic transmission, such as long-term potentiation (LTP). Here, we show using both vitro vivo recordings from the rat cerebellum that tetanization protocols for induction of LTP at parallel fiber (PF)-to-Purkinje cell synapses can also evoke increases intrinsic excitability. This form plasticity shares with a requirement activation protein phosphatases 1, 2A, 2B induction. Purkinje resembles CA1...
<h2>Summary</h2> Our tactile perception of external objects depends on skin-object interactions. The mechanics contact dictates the existence fundamental spatiotemporal input features—contact initiation and cessation, slip, rolling contact—that originate from fact that solid do not interpenetrate. However, it is unknown whether these features are represented within brain. We used a novel haptic interface to deliver such inputs glabrous skin finger/digit pads recorded neurons cuneate nucleus...
Neuronal function depends on the properties of synaptic inputs neuron receive and its intrinsic responsive properties. However, conditions for integration activation responses may to a large extent depend level background input. In this respect, deep cerebellar nuclear (DCN) neurons are particular interest: they feature massive input an intrinsic, postinhibitory rebound depolarization with profound effects integration. Using in vivo whole cell patch clamp recordings from DCN cells cat, we...
The computational principles underlying the processing of sensory-evoked synaptic inputs are understood only rudimentarily. A critical missing factor is knowledge activation patterns to neurons. Here we use well-defined, reproducible skin stimulation describe specific signal transformations that occur in different parallel mossy fiber pathways and analyze their representation cerebellar granule cells. We find input codes preserved responses cells, suggesting a coding-specific innervation....
Several lines of research have shown that the excitability inferior olive is suppressed during different phases movement. A number structures like cerebral cortex, red nucleus and cerebellum been suggested as candidate for mediating this gating. The inhibition responses olivary neurons from has studied extensively anatomical studies found specific areas within cuneate to be target projections magnocellular nucleus. In addition, GABA-ergic cells projecting found. We therefore tested if direct...
Abstract Apparent nitrogen‐use efficiency of the applied mineral N (NUE min ) in effluent from biodigested plant material (BE; C : org ratio 14:1; N–to–total 0.5:1) and a nitrate‐based inorganic fertilizer (IF), both at two rates was investigated six‐month pot experiment with Italian ryegrass ( Lolium multiflorum Lam.). Dry‐matter (DM) production 7% lower total amount aboveground biomass 8% BE than IF 40 d after sowing (DAS), equal 81 DAS, higher 136 172 DAS. NUE calculated on basis...
Discriminative touch relies on afferent information carried to the central nervous system by action potentials (spikes) in ensembles of primary afferents bundled peripheral nerves. These sensory quanta are first processed cuneate nucleus before is transmitted brain networks serving specific perceptual and sensorimotor functions. Here we report data integration synaptic inputs obtained with vivo whole cell patch clamp recordings from neurons this nucleus. We find that individual dominated 4-8...
A common method to explore the somatosensory function of brain is relate skin stimuli neurophysiological recordings. However, interaction with involves complex mechanical effects. Variability in mechanically induced spike responses likely be due part variability transformation into spiking patterns primary sensors located skin. This source greatly hampers detailed investigations response different types stimuli. novel stimulation technique designed minimize uncertainty strain distributions...
Despite our fine-grain anatomical knowledge of the cerebellar cortex, electrophysiological studies circuit information processing over last fifty years have been hampered by difficulty reliably assigning signals to identified cell types. We approached this problem assessing spontaneous activity signatures cortical neurones. A range statistics describing firing frequency and irregularity were then used, individually in combination, build Gaussian Process Classifiers (GPC) leading a...
Abstract Investigations of the mechanisms touch perception and decoding has been hampered by difficulties in achieving invariant patterns skin sensor activation. To obtain reproducible spatiotemporal activation sensory afferents, we used an artificial fingertip equipped with array neuromorphic sensors. The was to transduce real-world haptic stimuli into spikes. These spike were delivered afferents second digit rats via stimulation electrodes. Combined low-noise intra- extracellular...
The last few years have seen an increase in the variety of vivo experiments used for studying cerebellar physiological mechanisms. A combination ketamine and xylazine has become a particularly popular form anesthesia. However, because nonanesthetized control conditions are lacking these experiments, so far there been no evaluation effects drugs on activity neuronal network. In present study, we mossy fiber, parallel climbing fiber field potentials evoked nonanesthetized, decerebrated rat to...
Abstract The pathway from the deep cerebellar nuclei to inferior olive, source of climbing fibre input cerebellum, inhibits olivary transmission. As activity can depress background firing Purkinje cells, it was suggested that nucleo‐olivary (N–O) inhibition is a negative feedback mechanism for regulating cell excitability. This suggestion investigated, in set‐up with decerebrate ferrets, both by blocking and stimulating output while recording activity. Blocking N–O followed an increased...
This paper is concerned with the problem of tracking vehicles using radar detections. In particular, we deal problems where multiple detections are received from each target. According to recent studies, automotive sensors often receive a discrete set reflection centers. From these results, develop family sensor models suitable for tracking. A significant difficulty in performing this that it involves solving data association large number hypotheses. To reduce complexity problem, propose...
How the brain represents external world is an unresolved issue for neuroscience, which could provide fundamental insights into circuitry operation and solutions artificial intelligence robotics. The neurons of cuneate nucleus form first interface sense touch in brain. They were previously shown to have a highly skewed synaptic weight distribution tactile primary afferent inputs, suggesting that their connectivity strongly shaped by learning. Here we characterized intracellular dynamics...
To any model of brain function, the variability neuronal spike firing is a problem that needs to be taken into account. Whereas synaptic integration can described in terms original Hodgkin-Huxley (H-H) formulations conductance-based electrical signaling, transformation resulting membrane potential patterns output subjected stochasticity may not captured with standard single neuron H-H models. The dynamics dependent on normal background noise present vivo, but vivo well studied. In study, we...
Pavlovian eyeblink conditioning is a useful experimental model for studying adaptive timing, an important aspect of skilled movements. The conditioned response (CR) precisely timed to occur just before the onset expected unconditioned stimulus (US). timing can be changed immediately, however, by varying parameters (CS). It has previously been shown that increasing intensity peripheral CS or frequency consisting train stimuli mossy fibers shortens latency CR. behavioral CRs probably reflects...
Learning of classically conditioned eyeblink responses depends on mechanisms within the cerebellum. It has been suggested that climbing fibres from inferior olive transmit unconditioned stimulus signal to We have previously shown pathway deep cerebellar nuclei inhibits olivary activity. is known repeated presentation its own leads extinction response. If transmitted cerebellum via - fibre system then stimulation nucleo-olivary just before in a trained animal should lead extinction. The...