A5101788862- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- Sirtuins and Resveratrol in Medicine
- RNA regulation and disease
- Adipose Tissue and Metabolism
- Telomeres, Telomerase, and Senescence
- interferon and immune responses
- Atmospheric chemistry and aerosols
- Genetics, Aging, and Longevity in Model Organisms
- Ferroptosis and cancer prognosis
- Atmospheric Ozone and Climate
- RNA modifications and cancer
- Cancer-related Molecular Pathways
- Protein Degradation and Inhibitors
- Sperm and Testicular Function
- Histone Deacetylase Inhibitors Research
- Alzheimer's disease research and treatments
- ATP Synthase and ATPases Research
- Indoor Air Quality and Microbial Exposure
- Cytomegalovirus and herpesvirus research
- NF-κB Signaling Pathways
- Cancer, Lipids, and Metabolism
- Advanced Glycation End Products research
- Microtubule and mitosis dynamics
- Autophagy in Disease and Therapy
Capital Medical University
2021-2025
Beth Israel Deaconess Medical Center
2024-2025
Harvard University
2024-2025
Guangxi Zhuang Autonomous Region Health and Family Planning
2025
Beijing Geriatric Hospital
2022-2023
Peking University
2011-2023
Wuhan University of Science and Technology
2022
State Key Joint Laboratory of Environment Simulation and Pollution Control
2011
Duke University Hospital
1994
Duke Medical Center
1994
Apolipoprotein E (apoE), a plasma apolipoprotein that plays central role in lipoprotein metabolism, is localized the senile plaques, congophilic angiopathy, and neurofibrillary tangles of Alzheimer disease. Late-onset familial sporadic disease patients have an increased frequency one three common apoE alleles, epsilon 4, suggesting apoE4 associated with susceptibility to To follow up on this suggestion, we compared binding synthetic amyloid beta (beta/A4) peptide purified apoE3, most...
The apolipoprotein E (apoE) type 4 allele (APOE4) is a susceptibility gene for late-onset familial and sporadic Alzheimer disease. ApoE found in some neurofibrillary tangle-bearing neurons, one of the major pathologic hallmarks Neurofibrillary tangles contain paired helical filaments formed from hyperphosphorylated microtubule-associated protein tau. In vitro, tau binds avidly to apoE3, but not apoE4, forming bimolecular complex. Tau phosphorylated with brain extract does bind either...
Sirtuin 3 (SIRT3) is an NAD+-dependent deacetylase linked to a broad range of physiological and pathological processes, including aging aging-related diseases. However, the role SIRT3 in regulating human stem cell homeostasis remains unclear. Here we found that expression was downregulated senescent mesenchymal cells (hMSCs). CRISPR/Cas9-mediated depletion led compromised nuclear integrity, loss heterochromatin accelerated senescence hMSCs. Further analysis indicated interacted with envelope...
Abstract. Using a GC/FID/MS system, we analyzed the mixing ratio of 16 halocarbon species in more than 100 air samples collected 2004 from Pearl River Delta (PRD) region southern China. The results revealed that there are elevated ratios for most halocarbons, especially HClC = CCl2 (trichloroethylene, TCE), CH2Cl2 (dichloromethane, DCM), CH3 Br (bromomethane), HCFC-22, CHCl3 (trichloromethane), CCl4 (tetrachloromethane), Cl2C (perchloroethylene, PCE), CH3CCl3 (methyl chloroform, MCF), and...
Age-dependent loss of skeletal muscle mass and function is a feature sarcopenia, increases the risk many aging-related metabolic diseases. Here, we report phenotypic single-nucleus transcriptomic analyses non-human primate aging. A higher transcriptional fluctuation was observed in myonuclei relative to other interstitial cell types, indicating susceptibility fiber We found downregulation FOXO3 aged muscle, identified as hub transcription factor maintaining homeostasis. Through establishment...
The ovary is indispensable for female reproduction, and its age-dependent functional decline the primary cause of infertility. However, molecular basis ovarian aging in higher vertebrates remains poorly understood. Herein, we apply spatiotemporal transcriptomics to benchmark architecture organization as well cellular determinants young primate ovaries compare these aged ovaries. From a global view, somatic cells within non-follicle region undergo more pronounced transcriptional fluctuation...
Abstract. Aqueous phase chemical processes of organic compounds in the atmosphere have received increasing attention, partly due to their potential contribution formation secondary aerosol (SOA). Here, we analyzed aqueous OH-initiated oxidation isoprene and its reaction products including carbonyl acids, regarding acidity temperature as in-cloudy conditions. We also performed a laboratory simulation improve our understanding kinetics mechanisms for that are significant precursors SOA; these...
Sarcopenia, a skeletal muscle disorder in which loss of mass and function progresses with age, is associated increased overall frailty, risk falling mortality the elders. Here, we reveal that SESN1 safeguards from ageing downstream longevity gene FOXO3, recently reported geroprotector primate muscle. Knockdown mimicked human myotube phenotypes observed FOXO3-deficient myotubes, whereas genetic activation alleviated senescence. Of note, was identified as protective secretory factor against...
Abstract Ferroptosis is an iron-dependent form of regulated cell death characterized by lipid peroxidation. Colorectal cancer (CRC) cells evade ferroptosis despite their requirement substantial iron and reactive oxygen species (ROS) to sustain active metabolism extensive proliferation. However, the underlying mechanism unclear. Herein, we report role lymphoid-specific helicase (LSH), a chromatin-remodeling protein, in suppressing erastin-induced CRC cells. We demonstrate that erastin...
Although metabolic reprogramming is characterized as a hallmark of aging, implications the crucial glutamate dehydrogenase (GDH) in human senescence remain poorly understood. Here, we report that GDH activity significantly increased aged mice and senescent diploid fibroblasts. This enzymatic potentiation associated with de-repression from its functionally suppressive ADP-ribosylation modification catalyzed by NAD-dependent ADP-ribosyltransferase/deacetylase SIRT4. A series transcription...
Abstract Nucleolar proteins play an important role in the regulation of MDM2–p53 pathway, which coordinates cellular response to stress. However, mechanism underlying this remains poorly understood. Here, we report that nucleolar protein CSIG is a novel and crucial regulator pathway. We demonstrate translocates from nucleolus nucleoplasm Moreover, knockdown attenuates induction p53 abrogates G1 phase arrest interacts directly with MDM2 RING finger domain inhibits E3 ubiquitin ligase...
DNA damage-induced NF-κB activation and the secretion of inflammatory cytokines play crucial roles in carcinogenesis cellular senescence. However, underlying mechanisms, especially initial sensors transducers connecting nuclear damage signal with cytoplasmic remain incompletely understood. Here, we report that TRAF-interacting protein forkhead-associated domain (TIFA), an established activator cytosol, unexpectedly exhibited translocation accumulation on damaged chromatin following genotoxic...
Triple-negative breast cancer (TNBC) cells are often resistant to FAS (CD95)-mediated apoptosis, but the underlying molecular mechanism(s) is not fully understood yet. Notably, expression of type II transmembrane protein, CD74, correlated with chemotherapy-resistant and more invasive forms cancers via unknown mechanisms. Here, we analyzed gene pattern patients and/or patient-derived xenograft (PDX) models found that mRNA protein levels CD74 highly expressed in TNBC stem (CSCs)...
Abstract Hypoxia-inducible factor (HIF-1α), a core transcription responding to changes in cellular oxygen levels, is closely associated with wide range of physiological and pathological conditions. However, its differential impacts on vascular cell types molecular programs modulating human homeostasis regeneration remain largely elusive. Here, we applied CRISPR/Cas9-mediated gene editing embryonic stem cells directed differentiation generate HIF-1α-deficient including endothelial cells,...