Lei Zhang

ORCID: 0000-0002-6684-3794
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Research Areas
  • Chronic Obstructive Pulmonary Disease (COPD) Research
  • Asthma and respiratory diseases
  • Urinary and Genital Oncology Studies
  • EEG and Brain-Computer Interfaces
  • Myofascial pain diagnosis and treatment
  • Bladder and Urothelial Cancer Treatments
  • Pediatric health and respiratory diseases
  • Nerve Injury and Rehabilitation
  • Rheumatoid Arthritis Research and Therapies
  • Neurological disorders and treatments
  • Delphi Technique in Research
  • Sodium Intake and Health
  • Liver Disease Diagnosis and Treatment
  • Radiation Dose and Imaging
  • Restless Legs Syndrome Research
  • Inflammatory mediators and NSAID effects
  • Facial Nerve Paralysis Treatment and Research
  • Osteoarthritis Treatment and Mechanisms
  • Vascular Anomalies and Treatments
  • Infant Development and Preterm Care
  • Lymphatic System and Diseases
  • Anesthesia and Sedative Agents
  • Intracerebral and Subarachnoid Hemorrhage Research
  • Amyotrophic Lateral Sclerosis Research
  • Fibromyalgia and Chronic Fatigue Syndrome Research

Zhejiang Lab
2024

Nanjing University of Chinese Medicine
2024

Zhejiang University of Science and Technology
2024

Chinese Academy of Medical Sciences & Peking Union Medical College
2023

Second Xiangya Hospital of Central South University
2015-2023

Central South University
2015-2023

Tianjin Hospital
2023

Shanghai Ninth People's Hospital
2022

Shanghai Jiao Tong University
2022

Xuzhou Central Hospital
2022

The clinical diagnosis of Parkinson's disease (PD) is very difficult, especially in the early stage disease, because there no physiological indicator that can be referenced. Drug-free patients with PD are characterized by symptoms such as impaired motor function and cognitive decline, which was caused dysfunction brain's dynamic activities. indicators brain at an unmedicated condition may provide a valuable basis for later treatment. In order to find spatiotemporal characteristic markers PD,...

10.1016/j.nicl.2019.102132 article EN cc-by-nc-nd NeuroImage Clinical 2019-12-20

Objective: The goal of this study is to evaluate pulmonary function and respiratory center drive in patients with early-stage idiopathic Parkinson's disease (IPD) facilitate early diagnosis Disease (PD). Methods: 43 IPD (Hoehn Yahr scale 1) 41 matched healthy individuals (e.g. age, sex, height, weight, BMI) were enrolled study. Motor status was evaluated using the Movement Disorders Society-Unified PD Rating Scale (MDS-UPDRS). Pulmonary measured tests (PFT). All also subjected a series...

10.3389/fneur.2019.00724 article EN cc-by Frontiers in Neurology 2019-07-03

Recent developments in MIBC treatment suggest good efficacy of bladder sparing combined with immune checkpoint inhibitor. However, there is no standard mode. A retrospective analysis was conducted to reveal the and safety PD-1 inhibitor combination radiotherapy or chemoradiotherapy. We retrospectively analyzed 25 patients T2-T3N0M0 disease who were unfit unwilling undergo RC. These underwent maximum TURBT followed by (Tislelizumab Toripalimab) chemoradiotherapy (gemcitabine plus cisplatin)...

10.3389/fimmu.2023.1162580 article EN cc-by Frontiers in Immunology 2023-05-22

To explore a practical marker for quantitatively analyzing the small airway remodeling in COPD by HRCT. Twenty-four patients with (GOLD I, n = 7; GOLD II, 8; III+IV, 9) and 14 healthy controls (7 normal pulmonary function; 7 small-airway disease (SAD)) were enrolled study as five groups, SAD. All subjects underwent HRCT spirometry. With ISP 9.0, whole emphysema index (EI) parameters, including wall area (WA), lumen (LA), (AA) of 3rd, 5th 9th generations bronchi, measured successively. The...

10.2147/copd.s295320 article EN cc-by-nc International Journal of COPD 2021-03-01

Maxillary sinusitis is 1 of the postoperative complications Le Fort I osteotomy, this study investigated related factors maxillary after osteotomy. A total 23 cases, 92 controls, and 11 were included in case-control with a 1:4 ratio. The risk for examined by least absolute shrinkage selection operator multivariate conditional logistic regression linear regression. patency sinus ostium at 6 months surgery was significantly associated Compared obstructed ostium, percentage volume healthy air...

10.1097/scs.0000000000008450 article EN Journal of Craniofacial Surgery 2022-01-03

To explore the relationship between chronic periodontitis (CP) and depression-anxiety psychological factors.Thirty-one patients 29 age, gender-matched volunteers were enrolled for this study. In order to assess index, subjects filled questionnaire regarding demographic socioeconomic information, oral hygiene habit, Center Epidemiologic Studies Depression Scale (CES-D) Self Rating Anxiety Scale(ASA). Calculus index (CI), bleeding on probing (BOP), depth (PD), clinical attachment loss (CAL),...

10.3969/j.issn.1672-7347.2011.01.015 article EN PubMed 2011-01-01

To evaluate the service life of arteriovenous fistula (AVF) in patients with dialysis and to explore associated factors for AVF life. A cohort study regarding 472 cases AVFs at Second Xiangya Hospital from January 2009 December was retrospectively analyzed. The placement-associated primary secondary failure rates, complications various risk were examined. Kaplan-Meier survival curves Cox proportional hazard models used determine factors. By end 1st, 2014, after excluding indeterminate...

10.11817/j.issn.1672-7347.2015.08.013 article EN PubMed 2015-08-01

Epilepsy is an irregular and recurrent cerebral dysfunction that significantly impacts the affected individual's social functionality quality of life. This study aims to integrate cognitive dynamic attributes brain into seizure prediction, evaluating effectiveness various characterization perspectives for while delving impact varying fragment lengths on performance each characterization. We adopted microstate analysis extract properties states, calculated EEG-based microstate-based features...

10.3389/fnins.2024.1474782 article EN cc-by Frontiers in Neuroscience 2024-11-19

To explore the risk factors of acute respiratory distress syndrome (ARDS) in patients with sepsis and to construct a nomogram model.The clinical data 234 admitted intensive care unit (ICU) Tianjin Hospital from January 2019 May 2022 were retrospectively analyzed. The divided into non-ARDS group (156 cases) ARDS (78 according presence or absence ARDS. gender, age, hypertension, diabetes, coronary heart disease, smoking history, history alcoholism, temperature, rate (RR), mean arterial...

10.3760/cma.j.cn121430-20230215-00088 article EN PubMed 2023-07-01

Abstract Introduction: More patients with idiopathic scoliosis (IS) preferred to choose manual therapy as a complementary conservative treatment, but the effects of for IS remains controversial. The previous reviews could not draw reliable conclusion due few eligible studies perform meta-analysis. In last decade, however, several new were published that assessed in management IS, especially China. Therefore, present systematic review and meta-analysis will be performed examine whether is...

10.1097/md.0000000000021782 article EN cc-by-nc Medicine 2020-08-19

Objective To study the correlation between fractionlal exhaled nitric oxide(FeNO) levels and lung function about children with asthma in clinical remission. Methods Selecting 267 cases as research object, come from Cheng Du Women Children Hospital, measure their FeNO pulmonary function, analysis level function. Results There is no statistical difference male female remission.FeNO has positive heigh, weight, age(r=0.213, 0.147, 0.276; P=0.001, 0.025, 0.000)and negative pred % of...

10.3760/cma.j.issn.1673-4394.2015.01.005 article EN Int J Immunol 2015-01-05

Objective To investigate the impact of peripheral neuropathy on external anal sphincter electromyography (EAS-EMG). Methods EAS-EMG was performed in 36 patients with diabetic polyneuropathy (DPN), 58 multiple systemic atrophy (MSA) and 19 healthy controls.The routine nerve conduction study done standard EMG recorded from sphincter, common digital muscle anterior tibial muscle.Parameters studied included spontaneous activity (fibrillation potentials positive sharp waves), duration,...

10.3760/cma.j.issn.1006-7876.2013.05.004 article EN Chin J Neurol 2013-05-08
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