A5061478379- Child and Adolescent Psychosocial and Emotional Development
- Maternal Mental Health During Pregnancy and Postpartum
- Stress Responses and Cortisol
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Early Childhood Education and Development
- Heart Rate Variability and Autonomic Control
- Resilience and Mental Health
- Infant Development and Preterm Care
- Attention Deficit Hyperactivity Disorder
- Mental Health Research Topics
- Cardiac Health and Mental Health
- Autism Spectrum Disorder Research
- Pregnancy and preeclampsia studies
- Tryptophan and brain disorders
- Identity, Memory, and Therapy
- Nerve injury and regeneration
- Birth, Development, and Health
- Genetics and Neurodevelopmental Disorders
- Adolescent and Pediatric Healthcare
- Asthma and respiratory diseases
- Estrogen and related hormone effects
- Childhood Cancer Survivors' Quality of Life
- Family Support in Illness
- Amino Acid Enzymes and Metabolism
- Neuroscience and Neuropharmacology Research
Vadaskert Alapítvány a Gyermekek Lelki Egészségéért
2005-2025
Semmelweis University
2014-2024
University of Szeged
2009-2021
University of South Florida
2018
James A. Haley Veterans' Hospital
2018
University of Pittsburgh
2018
University of Pittsburgh Medical Center
2018
American Academy of Child and Adolescent Psychiatry
2015
Centre for Addiction and Mental Health
2008
Depression in adults is associated with risk factors for cardiovascular disease (CVD). It unclear, however, when the association between clinical depression and cardiac develops or how early life this can be detected.In an ongoing study of pediatric depression, we compared CVD including smoking, obesity, physical activity level, sedentary behavior, parental history across three samples adolescents: probands established histories childhood-onset major depressive disorder (n = 210),...
Successful mood repair (i.e., attenuating sad, dysphoric affect) is a critical form of emotion regulation that necessary for healthy functioning. Laboratory-based studies have examined how well individuals can reduce sadness and this process affected by psychopathology like depression cognitive mechanisms attentional control. However, the extent to which laboratory-based findings inform about in daily life unknown. To examine ecological validity paradigms, we compared success laboratory...
Depressive disorders that onset in the juvenile years have been linked to far-reaching adverse consequences, making it imperative elucidate key mechanisms and contributory factors. Excessive use of regulatory responses exacerbate sadness (maladaptive mood repair) or insufficient reduce (adaptive may reflect behavioral depression risk. Cardiac vagal control, indexed by patterns respiratory sinus arrhythmia (RSA), has received attention as a putative physiological risk factor for depression....
<i>Background/Aims:</i> Inflammatory cytokines induce a behavioral syndrome, known as sickness behavior, that strongly resembles symptoms typically seen in depression. This resemblance has led to the theory an imbalance of inflammatory cytokine activity may be contributing factor depressive disorders. Support for this is found multiple lines evidence, such effects on activities hypothalamic-pituitary-adrenal axis, serotonin and brain-derived neurotrophic factor, hippocampal...
The chromosome 1p36 region was previously indicated as a locus for susceptibility to recurrent major depressive disorder based on linkage study in sample of 497 sib pairs. We investigated the gamma‐aminobutyric acid A (GABA ) δ receptor subunit gene, GABRD , gene childhood‐onset mood disorders (COMD) because substantial evidence implicating GABAergic dysfunction and position this near region. Using consisting 645 Hungarian families with child/adolescent proband diagnosed onset first episode...
Because depressive illness is recurrent, recurrence prevention should be a mainstay for reducing its burden on society. One way to reach this goal identify malleable risk factors. The ability attenuate sadness/dysphoria (mood repair) and parasympathetic nervous system functioning, indexed as respiratory sinus arrhythmia (RSA), are impaired during depression after it has remitted. present study therefore tested the hypothesis that these two constructs also may mirror factors recurrent major...
The purpose of this study was to investigate the impact postpartum depressive and anxiety symptoms on maternal perception infant protective role social support.Adverse effects perinatal depression mother-child interaction are well documented; however, has not been examined.We used data 431 women enrolled in a prospective single maternity unit. Depressive were measured using Edinburgh Postnatal Depression Scale (EPDS), State Trait Anxiety Inventory (STAI), mother's with Mother's Object...
Genome scans have revealed significant evidence for linkage of depression to chromosome 15q25.3-q26.2. The gene neurotrophic tyrosine kinase receptor 3 (NTRK3), the neurotrophin-3 (trkC) and a key in neurotrophin signaling, is located within this region and, given synaptic plasticity as mechanism mood disorders, was considered prime candidate. authors investigated NTRK3 susceptibility childhood-onset disorders.The study sample consisted 603 families with 723 affected children adolescents...
Article AbstractObjective: To determine whether the symptom presentation of major depressive disorder (MDD) in a large clinical sample youngsters is influenced by age, sex, and interaction age sex.Method: The included 559 children (mean age†‰=†‰11.69 years; range, 7-14 247 girls) with MDD recruited from 23 mental health facilities across Hungary. Psychiatric evaluations were conducted via semistructured Interview Schedule for Children Adolescents-Diagnostic Version (ISCA-D). Final DSM-IV...
Background Impaired emotion regulation is increasingly recognized as a core feature of depressive disorders. Indeed, currently and previously depressed adults both report greater problems in attenuating sadness (mood repair) daily life than healthy controls. In contrast, studies various strategies to attenuate sad affect have mostly found that or controls were similarly successful at mood repair the laboratory. But few examined among depression‐prone youths effects trait characteristics on...
Objectives Impaired positive autobiographical memory ( AM ) is closely linked to emotional disorders. impairments are often found in depressed adults and may be related the difficulties such persons have regulating their dysphoric mood. By contrast, less known about disturbances among adolescents, or functional relationship of early‐onset depression. Design A high‐risk family design served compare four groups youth who differed depression histories familial risk. Methods Thirty‐one currently...
Although hedonic capacity is diminished during clinical depression, it unclear whether that deficit constitutes a risk factor or persists after depression episodes remit. To examine these issues, adolescents with current/past major (probands; n = 218), never-depressed biological siblings of probands ( 207), and emotionally well controls 183) were exposed to several positively valenced probes. Across baseline probe conditions, consistently reported higher levels positive affect than high-risk...
Abstract Suicidal thoughts and behaviors (STBs) have been associated with emotion dysregulation atypical responses to affective stressful stimuli. To investigate the psychophysiology involved, we measured changes in respiratory sinus arrhythmia (RSA) cardiac pre‐ejection period (PEP; indexing parasympathetic sympathetic functioning, respectively) response stressful‐ sadness‐eliciting laboratory probes. Our sample included adolescents a history of depression STBs ( n = 177), but no 47),...
Depressive disorders are heterogeneous psychiatric involving deficits in cognitive, psychomotor, and emotional processing. have a significant genetic component, with severe, recurrent early-onset forms demonstrating elevated heritability. In this study we genotyped eleven single nucleotide polymorphisms (SNPs) spanning the estrogen receptor alpha gene (ESR1) large family-based childhood-onset mood disorder (COMD) sample. None of individual SNP or global haplotype analyses was entire COMD...
Studies in both animals and humans advocate a role for the vasopressin (AVP) system aetiology of depressive symptoms. Attention has particularly focused on AVP overactivation hypothalamic-pituitary-adrenal (HPA)-axis mood disorders. Elevated plasma levels have been found disorder patients, which are often positively correlated with severity We recently reported an association between childhood-onset disorders (COMD) polymorphisms receptor responsible AVP-mediated activation HPA-axis...
Abstract Childhood‐onset mood disorders (COMD) are often familial, and twin studies of COMD provide compelling evidence that genetic factors involved. Deficits in neural plasticity have been suggested to underlie the development depression. The receptor tropomyosin related kinase B (TrkB) its ligand, brain derived neurotrophic factor (BDNF), play essential roles plasticity, mRNA expression both these genes has shown be influenced by stress chronic antidepressant treatment. In addition, TrkB...
Affect regulation skills develop in the context of family environment, wherein youths are influenced by their parents', and possibly siblings', regulatory responses styles. Regulatory to sadness (mood repair) that exacerbate or prolong dysphoria (maladaptive mood may represent one way which depression is transmitted within families. We examined self-reported adaptive maladaptive repair across cognitive, social behavioural domains Hungarian 11- 19-year-old youth parents. Offspring included...
Background: Both depression and anxiety (two of the most common internalizing psychopathology among youths) are associated with difficulties in emotion regulation (ER). Little is known about whether as a comorbid condition has an effect on habitual use different ER strategies youngsters histories. We aimed (1) to compare adolescents histories childhood onset major (MDD) without (2) examine certain response clusters (Cognitive, Social, Behavioral/Physical) characterize children adolescents....
Background: Depression has been shown to have adverse effects on blood pressure (BP) and is associated with high variability (BPV). In turn, short-term BPV related eventual cardiovascular risk. But it not clear how early in adulthood the detrimental of depression may be discerned, if being at risk for also compromises BPV, whether clinical features moderate its effects. We investigated these three issues among young adults using an office-like setting. Methods: total, 218 subjects a history...