A5101552002- Immune Response and Inflammation
- COVID-19 diagnosis using AI
- Computational Drug Discovery Methods
- Radiomics and Machine Learning in Medical Imaging
- Gut microbiota and health
- Neonatal and fetal brain pathology
- Viral Infections and Outbreaks Research
- SARS-CoV-2 and COVID-19 Research
- Infant Nutrition and Health
- Artificial Intelligence in Healthcare and Education
- Machine Learning in Healthcare
- Influenza Virus Research Studies
- Glaucoma and retinal disorders
- CAR-T cell therapy research
- PARP inhibition in cancer therapy
- Protein Degradation and Inhibitors
- Nanowire Synthesis and Applications
- Cancer Immunotherapy and Biomarkers
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Reproductive Physiology in Livestock
- Retinal Development and Disorders
- Immunotherapy and Immune Responses
- Neuroscience and Neuropharmacology Research
- Immune Cell Function and Interaction
New York University
2023
Tuen Mun Hospital
2021-2022
Neoleukin Therapeutics (United States)
2020-2021
Florida College
2017-2021
University of Florida
2017-2021
Regeneron (United States)
2018-2020
Data privacy mechanisms are essential for rapidly scaling medical training databases to capture the heterogeneity of patient data distributions toward robust and generalizable machine learning systems. In current COVID-19 pandemic, a major focus artificial intelligence (AI) is interpreting chest CT, which can be readily used in assessment management disease. This paper demonstrates feasibility federated method detecting related CT abnormalities with external validation on patients from...
We developed a de novo protein design strategy to swiftly engineer decoys for neutralizing pathogens that exploit extracellular host proteins infect the cell. Our pipeline allowed design, validation, and optimization of human angiotensin-converting enzyme 2 (hACE2) neutralize severe acute respiratory syndrome coronavirus (SARS-CoV-2). The best monovalent decoy, CTC-445.2, bound with low nanomolar affinity high specificity receptor-binding domain (RBD) spike protein. Cryo-electron microscopy...
For most classes of drugs, rapid development therapeutics to treat emerging infections is challenged by the timelines needed identify compounds with desired efficacy, safety, and pharmacokinetic profiles. Fully human monoclonal antibodies (mAbs) provide an attractive method overcome many these hurdles rapidly produce for diseases. In this study, we deployed a platform generate, test, develop fully Zaire ebolavirus. We obtained specific anti-Ebola virus (EBOV) immunizing VelocImmune mice that...
CD28 bispecific antibodies are well tolerated and enhance the antitumor efficacy of CD3 bispecifics as a potential off-the-shelf antibody therapy.
G protein-coupled receptors (GPCRs) are the largest class of in genome and control many signaling cascades essential for survival. GPCR is regulated by β-arrestins, multifunctional adapter proteins that direct receptor desensitization, internalization, signaling. While at GPCRs, β-arrestins interact with a wide array effectors, it unclear how promote such varied functions. Here we show undergo liquid-liquid phase separation (LLPS) to form condensates regulate function. We demonstrate...
Abstract Triaging and prioritising patients for RT-PCR test had been essential in the management of COVID-19 resource-scarce countries. In this study, we applied machine learning (ML) to task detection SARS-CoV-2 infection using basic laboratory markers. We performed statistical analysis trained an ML model on a retrospective cohort 5148 from 24 hospitals Hong Kong classify other aetiology pneumonia. validated three temporal validation sets different waves Kong. For predicting infection,...
Glaucoma is an age-related neurodegenerative disease of the visual system, affecting both eye and brain. Yet its underlying metabolic mechanisms neurobehavioral relevance remain largely unclear. Here, using proton magnetic resonance spectroscopy functional imaging, we investigated GABAergic glutamatergic systems in cortex glaucoma patients, as well neural specificity, which shaped by GABA glutamate signals underlies efficient sensory cognitive functions. Our study shows that among older...
Herein we describe an association between activation of inflammatory pathways following transient hypoxia and the appearance multidrug resistant bacteria Staphylococcus simulans in fetal brain. Reduction maternal arterial oxygen tension by 50% over 30 min resulted a subseiuent significant over-expression genes associated with immune responses 24 h later The activated were consistent stimulation bacterial lipopolysaccharide; influx macrophages live found these brains. S. was predominant...
Fetal development is thought to proceed in a sterile environment. Recent reports of the presence bacterial DNA human placenta, transfer live bacteria from mother fetus after hypoxia pregnant sheep, and meconium newborn infants have suggested that might be exposed utero. The present experiments were designed test hypothesis small numbers introduced into maternal bloodstream (too few induce fever or changes food consumption), can found days later. We injected 100 colony forming units green-,...
Abstract The fetus develops in a privileged environment, as the placenta serves both gateway for nutrients and barrier pathogen transfer to fetus. Regardless, recent evidence suggests presence of bacterial DNA fetus, we have reported that protein from small numbers bacteria gain access maternal bloodstream. Other routes environmental mother remain unknown, well physiological relevance their presence. In these experiments, examine multiple by which cellular components can enter fetal response...
There is an urgent need for the ability to rapidly develop effective countermeasures emerging biological threats, such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that causes ongoing disease 2019 (COVID-19) pandemic. We have developed a generalized computational design strategy engineer de novo proteins precisely recapitulate protein surface targeted by agents, like viruses, gain entry into cells. The designed act decoys block cellular and aim be resilient viral...
The fetus is thought to develop in a sterile environment utero. Long standing dogma that “the uterus and the feto‐placental unit “sterile” based primarily on microbiological culture‐based techniques were unsuccessful growing “culture resistant” bacteria or intracellular bacteria. We have reported presence of low numbers tissues from normal sheep fetuses pregnancies not complicated by infection. exposure might aid neonatal survival informing fetal immune development. propose fragments can be...
The concept of the fetal microbiome is beginning to gain traction as new evidence bacterial presence in tissues arise. With bacteria mounting, it becomes important find out how fetus responds increasing bacteria. In our previous studies, we reported that small numbers (too few cause fever or behavioral response) inoculated into maternal sheep during late gestation can be detected tissues. present study, hypothesize transfer these low from mother stimulate a transcriptomic response brain, and...
<h3>Background</h3> NL-201 is a potent, selective, and long-acting computationally designed alpha-independent agonist of the IL-2 IL-15 receptors that being developed as an immunotherapy for cancer. Intravenous administration active in numerous pre-clinical tumor models. Here, we report data demonstrating favorable tolerability, pharmacokinetics, antitumor activity after intratumoral (IT) syngeneic murine <h3>Methods</h3> Mice were implanted with colorectal tumors single (right flank) or...
Abstract Background Using a computational approach, NL-CVX1 was developed by Neoleukin Therapeutics, Inc. to create de novo protein that both blocks SARS-CoV-2 infection and is highly resilient viral escape. In this study we evaluated the efficacy of against variants original strain, including important concern (VOC) such as B.1.1.7, B.1.351, P.1. Methods The relative binding affinity spike VOC measured using biolayer interferometry (Octet). A competitive ELISA ability compete with hACE2 for...