A5056098452- Effects and risks of endocrine disrupting chemicals
- Estrogen and related hormone effects
- RNA Research and Splicing
- Genomics and Chromatin Dynamics
- Metabolomics and Mass Spectrometry Studies
- Stress Responses and Cortisol
- Consumer Attitudes and Food Labeling
- Nutritional Studies and Diet
- Biotin and Related Studies
- interferon and immune responses
- RNA Interference and Gene Delivery
- Vitamin D Research Studies
- Molecular Biology Techniques and Applications
- Adipose Tissue and Metabolism
- bioluminescence and chemiluminescence research
- Cell death mechanisms and regulation
- Toxoplasma gondii Research Studies
- Nutrition, Genetics, and Disease
- Toxic Organic Pollutants Impact
University of California, Irvine
2020-2023
Massachusetts General Hospital
2023
University of California System
2023
Stanford University
2014
Abstract The balance between controlling infection and limiting inflammation is particularly precarious in the brain because of its unique vulnerability to toxic effects inflammation. Astrocytes have been implicated as key regulators neuroinflammation CNS infections, including with Toxoplasma gondii, a protozoan parasite that naturally establishes chronic mice humans. In toxoplasmosis, astrocytes are critical growth. They secrete proinflammatory cytokines physically encircle parasites....
Burgeoning evidence demonstrates that responses to environmental exposures can be transmitted subsequent generations through the germline without DNA mutations 1,2 . This is controversial because underlying mechanisms remain identified. Therefore, understanding how effects of are unexposed a fundamental unanswered question in biology. Here, we used an established murine model transgenerational obesity show direct or ancestral exposure obesogen tributyltin (TBT) elicited persistent changes...
Polychlorinated biphenyls (PCBs) are environmental toxicants; PCB exposure has been associated with adverse effects on wildlife and humans. However, the mechanisms underlying these not fully understood. The steroid xenobiotic receptor [SXR; also known as pregnane X (PXR) formally NR1I2] is a nuclear hormone that regulates inducible metabolism of drugs xenobiotics activated or inhibited by various congeners.The aim this study was to investigate PCB-153, most prevalent congener in human...
Abstract Burgeoning evidence demonstrates that effects of environmental exposures can be transmitted to subsequent generations through the germline without DNA mutations 1,2 . This phenomenon remains controversial because underlying mechanisms have not been identified. Therefore, understanding how are unexposed is a fundamental unanswered question in biology. Here, we used an established murine model male-specific transgenerational obesity show exposure obesogen tributyltin (TBT) elicited...