A5024471618- Effects and risks of endocrine disrupting chemicals
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Toxic Organic Pollutants Impact
- Epigenetics and DNA Methylation
- Health, Environment, Cognitive Aging
- Molecular Biology Techniques and Applications
- Peroxisome Proliferator-Activated Receptors
- Nutrition, Genetics, and Disease
- Genomics and Chromatin Dynamics
- bioluminescence and chemiluminescence research
- Fatty Acid Research and Health
- Diet and metabolism studies
- Meat and Animal Product Quality
- Chronic Myeloid Leukemia Treatments
- Aquaculture Nutrition and Growth
- Metabolism and Genetic Disorders
- Retinoids in leukemia and cellular processes
- Adipokines, Inflammation, and Metabolic Diseases
- Pharmacological Effects of Natural Compounds
- Marine Biology and Environmental Chemistry
- Microplastics and Plastic Pollution
- Vitamin C and Antioxidants Research
- Metabolomics and Mass Spectrometry Studies
- RNA Research and Splicing
University of California, Irvine
2012-2023
Irvine University
2023
University of California, Santa Cruz
2021-2023
Universidad Autónoma de Madrid
2012
We have previously shown that exposure to tributyltin (TBT) modulates critical steps of adipogenesis through RXR/PPARγ and prenatal TBT predisposes multipotent mesenchymal stem cells (MSCs) become adipocytes by epigenetic imprinting into the memory MSC compartment.We tested whether effects were heritable in F2 F3 generations.We exposed C57BL/6J female mice (F0) DMSO vehicle, pharmaceutical obesogen rosiglitazone (ROSI), or (5.42, 54.2, 542 nM) throughout pregnancy via drinking water. F1...
Background: Bisphenol A (BPA) and bisphenol diglycidyl ether (BADGE), used in manufacturing coatings resins, leach from packaging materials into food. Numerous studies suggested that BPA BADGE may have adverse effects on human health, including the possibility exposure to such chemicals can be superimposed traditional risk factors initiate or exacerbate development of obesity. is a suspected obesogen, whereas BADGE, described as peroxisome proliferator–activated receptor gamma (PPARγ)...
Ancestral environmental exposures to non-mutagenic agents can exert effects in unexposed descendants. This transgenerational inheritance has significant implications for understanding disease etiology. Here we show that exposure of F0 mice the obesogen tributyltin (TBT) throughout pregnancy and lactation predisposes F4 male descendants obesity when dietary fat is increased. Analyses body fat, plasma hormone levels, visceral white adipose tissue DNA methylome transcriptome collectively...
Background:In ToxCast™ Phase I, the U.S. EPA commissioned screening of 320 pesticides, herbicides, fungicides, and other chemicals in a series high-throughput assays. The agency also developed toxicological prioritization tool, ToxPi, to facilitate using assays predict biological function.Objectives:We asked whether top-scoring PPARγ activators identified I were genuine inducers adipogenesis. Next, we that should adipogenesis, an adipogenesis how well ToxPi predicted adipogenic...
Early life exposure to endocrine-disrupting chemicals (EDCs) is an emerging risk factor for the development of obesity and diabetes later in life. We previously showed that prenatal EDC tributyltin (TBT) results increased adiposity offspring. These effects linger into adulthood are propagated through successive generations. TBT activates two nuclear receptors, peroxisome proliferator-activated receptor (PPAR) γ its heterodimeric partner retinoid X (RXR), promote adipogenesis vivo vitro....
Background: The organotin dibutyltin (DBT) is used in the manufacture of polyvinyl chloride (PVC) plastics, construction materials, and medical devices. Previous animal studies showed detrimental effects DBT during utero development at relatively high doses, but little was known about exposure environmentally relevant doses on endpoints such as obesity metabolic disease. Objectives: We tested potential obesogenic using vitro vivo models. Methods. evaluated nuclear receptor activation...
Abstract Exposure to environmental stressors is known increase disease susceptibility in unexposed descendants the absence of detectable genetic mutations. The mechanisms mediating environmentally-induced transgenerational are poorly understood. We showed that great-great-grandsons female mice exposed tributyltin (TBT) throughout pregnancy and lactation were predisposed obesity due altered chromatin organization subsequently biased DNA methylation gene expression. Here we analyzed methylomes...
Hematopoiesis is a complex process regulated by both cell intrinsic and extrinsic factors. Alterations in the expression of critical genes during hematopoiesis can modify balance between stem differentiation proliferation, may ultimately give rise to leukemia other diseases. AF10 transcription factor that has been implicated development following chromosomal rearrangements gene one at least two genes, MLL CALM. The link leukemia, together with known interactions hematopoietic regulators,...
Abstract Ancestral environmental exposures to non-mutagenic agents can exert effects in unexposed descendants. This transgenerational inheritance has significant implications for understanding disease etiology. The obesogen hypothesis proposes that exposure obesogenic chemicals lead increased adiposity, vivo . Here we show of F0 mice the tributyltin (TBT) throughout pregnancy and lactation predisposes F4 male descendants obesity when dietary fat is increased. Analyses body fat, plasma...
Abstract Disclosure: S.R. Aguiar: None. R. Chamorro-Garcia: Exposure to endocrine-disrupting chemicals (EDCs) found in our environment can increase the risk of susceptibility metabolic diseases, such as obesity and type 2 diabetes. Tobacco products harbor a cluster harmful EDCs that are inhaled by smokers dispersed through air. Previous research showed tobacco exposure during pregnancy lead developmental alterations disease offspring later into adulthood. Although global use is higher among...
Abstract Disclosure: D.D. Davis: None. R. Chamorro-Garcia: C. Diaz-Castillo: Tobacco products harbor a heterogeneous cluster of endocrine-disrupting chemicals (EDCs) that can lead to many adverse health effects, including obesity and other metabolic diseases. During critical developmental windows, exposure EDCs found in tobacco products, inorganic arsenic (iAs) nicotine, increase susceptibility these An understudied window significant influence on the developing effects future generations is...