A5090078796- Supramolecular Self-Assembly in Materials
- 3D Printing in Biomedical Research
- Bone Tissue Engineering Materials
- RNA Interference and Gene Delivery
- Connective tissue disorders research
- Bone and Dental Protein Studies
- Silk-based biomaterials and applications
- Polydiacetylene-based materials and applications
- Electrospun Nanofibers in Biomedical Applications
- Chemical Synthesis and Analysis
- Cellular Mechanics and Interactions
- Additive Manufacturing and 3D Printing Technologies
- Graphene and Nanomaterials Applications
- Diatoms and Algae Research
- Nanofabrication and Lithography Techniques
- Lipid Membrane Structure and Behavior
- Orthopaedic implants and arthroplasty
- Innovative Microfluidic and Catalytic Techniques Innovation
- Nanoplatforms for cancer theranostics
- Cancer Cells and Metastasis
- Polymer Surface Interaction Studies
- Proteoglycans and glycosaminoglycans research
- Advanced biosensing and bioanalysis techniques
- Tissue Engineering and Regenerative Medicine
- Cell Adhesion Molecules Research
University of Nottingham
2019-2025
Sunny BioDiscovery (United States)
2025
Nottingham Biomedical Research Centre
2023-2024
Queen Mary University of London
2015-2024
Universidad Autónoma del Estado de Morelos
2023-2024
Hospital General Universitario Gregorio Marañón
2023
Universidad Publica de Navarra
2021
Universidad de Navarra
2021
AO Foundation
2021
Queen Margaret University
2020
We report here the self-assembly of macroscopic sacs and membranes at interface between two aqueous solutions, one containing a megadalton polymer other, small self-assembling molecules bearing opposite charge. The resulting structures have highly ordered architecture in which nanofiber bundles align reorient by nearly 90 degrees as membrane grows. formation diffusion barrier upon contact liquids prevents their chaotic mixing. hypothesize that growth is then driven dynamic synergy osmotic...
The fabrication of multi-level SU-8 microstructures using multiple coating and exposure steps a single developing step has been achieved for up to six layers SU-8. Alternating 2010 (thin) 2100 (thick) photoresist films were spin coated, followed by soft-bake, ultraviolet (UV) post-exposure bake steps. simultaneously developed create patterned with overall thicknesses 500 µm minimum lateral feature size 10 µm. use facilitated complex that might be difficult, or even impossible, achieve...
Abstract A major goal in materials science is to develop bioinspired functional based on the precise control of molecular building blocks across length scales. Here we report a protein-mediated mineralization process that takes advantage disorder–order interplay using elastin-like recombinamers program organic–inorganic interactions into hierarchically ordered mineralized structures. The comprise elongated apatite nanocrystals are aligned and organized microscopic prisms, which grow together...
Microscale topographical features have been known to affect cell behavior. An important target in this area is integrate top down techniques with bottom up self-assembly create three-dimensional (3D) patterned bioactive mimics of extracellular matrices. We report a novel approach toward goal and demonstrate its use study the behavior human mesenchymal stem cells (hMSCs). By incorporating polymerizable acetylene groups hydrophobic segment peptide amphiphiles (PAs), we were able micro-pattern...
Self-assembled nanofibers are ubiquitous in nature and serve as inspiration for the design of supramolecular hydrogels. A multicomponent approach offers possibility enhancing tunability functionality this class materials. We report on synergistic self-assembly involving a peptide amphiphile (PA) 1,3:2,4-dibenzylidene-d-sorbitol (DBS) gelator to generate hydrogels with tunable nanoscale morphology, improved stiffness, enhanced self-healing, stability enzymatic degradation. Using induced...
Effective integration of molecular self-assembly and additive manufacturing would provide a technological leap in bioprinting. This article reports on biofabrication system based the hydrodynamically guided co-assembly peptide amphiphiles (PAs) with naturally occurring biomolecules proteins to generate hierarchical constructs tuneable composition structural control. The takes advantage droplet-on-demand inkjet printing exploit interfacial fluid forces guide into aligned or disordered...
Patient-derived in vivo models of human cancer have become a reality, yet their turnaround time is inadequate for clinical applications. Therefore, tailored ex that faithfully recapitulate tumour biology are urgently needed. These may especially benefit the management pancreatic ductal adenocarcinoma (PDAC), where therapy failure has been ascribed to its high stem cell (CSC) content and density stromal cells extracellular matrix (ECM). To date, these features only partially reproduced using...
Abstract Synthetic osteo‐promoting materials that are able to stimulate and accelerate bone formation without the addition of exogenous cells or growth factors represent a major opportunity for an aging world population. A co‐assembling system integrates hyaluronic acid tyramine ( HA‐Tyr ), bioactive peptide amphiphiles GHK‐Cu 2+ Laponite Lap ) engineer hydrogels with physical, mechanical, biomolecular signals can be tuned enhance regeneration is reported. The central design element...
Abstract Biological structures are inherently complex in nature. Structural hierarchy, chemical anisotropy, and compositional heterogeneity ubiquitous biological systems play a key role the functionality of living systems. For decades, methods such as soft lithography have enabled recreation arrangements through precise spatial control molecular patterns 2D. With technological advances increasing understanding structural biology, there has been an interest recreating organizations 3D. In...
During tooth development, ectoderm-derived ameloblast cells create enamel by synthesizing a complex protein mixture serving to control cell matrix interactions and the habit of hydroxyapatite crystallites. Using an in vitro organ culture system, we studied effect artificial bioactive nanostructures on ameloblasts with long-term goal developing cell-based strategies for regeneration. We used branched peptide amphiphile molecules containing motif Arg-Gly-Asp, or "RGD" (abbreviated BRGD-PA),...
A three-dimensional (3D) structure comprising precisely defined micro-architecture and surface micro-textures, designed to present specific physical cues cells tissues, may provide an efficient scaffold in a variety of tissue engineering regenerative medicine applications. We report fabrication technique based on microfabrication soft lithography that permits for the development 3D scaffolds with both engineered architecture tailored topography. The consists three key steps starting mold...