A5072316568- Tissue Engineering and Regenerative Medicine
- Electrospun Nanofibers in Biomedical Applications
- Nerve injury and regeneration
- Photodynamic Therapy Research Studies
- Pelvic floor disorders treatments
- Reconstructive Surgery and Microvascular Techniques
- Proteoglycans and glycosaminoglycans research
- Antifungal resistance and susceptibility
- Anorectal Disease Treatments and Outcomes
- Cardiac Structural Anomalies and Repair
- RNA Interference and Gene Delivery
- Hernia repair and management
- Plant Pathogens and Fungal Diseases
- Renal and related cancers
- Orthopaedic implants and arthroplasty
- Osteoarthritis Treatment and Mechanisms
- Nerve Injury and Rehabilitation
- Infectious Diseases and Tuberculosis
- Nanoplatforms for cancer theranostics
- Fungal Infections and Studies
- Silk-based biomaterials and applications
- Wound Healing and Treatments
- Tendon Structure and Treatment
- Prenatal Screening and Diagnostics
- Mesenchymal stem cell research
Banc de Sang i Teixits
2019-2024
Institut d'Investigacions Biomèdiques de Barcelona
2021-2024
Biomedical Research Institute
2021-2023
Hospital de Sant Pau
2022
Eindhoven University of Technology
2022
Institut Químic de Sarrià
2011-2016
Universitat Ramon Llull
2011-2016
Hypericin is a natural photosensitizer considered for the new generation of photodynamic therapy (PDT) drugs. The aim this study was to evaluate in vitro fungicidal effect hypericin PDT on various Candida spp., assessing its photocytotoxicity keratinocytes (HaCaT) and dermal fibroblasts (hNDF) determine possible side effects. A 3 log observed at 0.5 McFarland two albicans strains, parapsilosis krusei with concentrations 0.625, 1.25, 2.5 40 μm, respectively, fluence 18 J cm(-2) (LED lamp...
Decellularized nerve allografts are an alternative to autograft for repairing severe injuries, since they have higher availability and do not induce rejection. In this study, we assessed the regenerative potential of a novel decellularization protocol human rat nerves resections, compared gold standard autograft. A 15-mm gap in sciatic was repaired with decellularized allograft (DC-RA), xenograft (DC-HX), or fresh (AG). Electrophysiology tests were performed monthly evaluate muscle...
Abstract The aims of this study were to evaluate the feasibility New Zealand White (NZW) rabbit for studying implanted biomaterials in pelvic reconstructive surgery; and compare occurrence graft-related complications a commercial polypropylene (PP) mesh new developed human dermal matrix at vaginal abdominal level. 20 white female NZW rabbits randomized into two groups, experimental group (human acellular matrices-hADM-graft) control (commercial PP graft). In each animal, grafts surgically...
BACKGROUND AND OBJECTIVES: Peripheral nerve injuries resulting in a defect require surgical repair. The gold standard of autograft (AG) has several limitations, and therefore, new alternatives must be developed. main objective this study was to assess regeneration through long gap injury (50 mm) the peroneal sheep with decellularized allograft (DCA). METHODS: A 5-cm made repaired using an AG or DCA. Functional tests were performed once month electrophysiology echography evaluations at 6.5 9...
Can risks associated with novelties in assisted reproduction technologies (ARTs) be assessed a systematic and structured way?An ART-specific risk assessment tool has been developed to assess the development of ART (EuroGTP II-ART).How implement new is well-described literature. The successive steps should include testing animal models, executing pre-clinical studies using supernumerary gametes or embryos, prospective clinical trials finally, short- long-term follow-up on health offspring. A...
Tissue engineering, which involves the use of therapeutic biologicals supported by implantable materials, represents a promising tool to repair damaged tissues or organs. Among most proper supporting materials and scaffolds, natural extracellular matrix (ECM) constitutes dynamic platform structural functional fibers biomolecules that confers suitable microenvironment for cell attachment, proliferation differentiation via activation host signaling cues. In this context, ECM derived from human...
Antimicrobial photodynamic therapy combines the use of a photosensitizing drug with light and oxygen to eradicate pathogens. Trichophyton mentagrophytes is dermatophytic fungus able invade skin keratinized tissues. We have investigated new methylene blue as agent for antimicrobial produce in vitro inactivation T mentagrophytes. A full factorial design was employed optimize parameters photoinactivation dermatophyte. The studied were concentration, contact time between prior treatment, fluence...
The activities of tissue establishments are constantly and rapidly evolving. development a new type allograft, full-thickness acellular dermal matrix, with high mechanical properties to be used in tendon repair surgeries abdominal wall reconstruction, has determined the need for quality by design process order assess evidence quality, safety efficacy. EuroGTPII methodologies were specifically tailored perform risk assessment, identify suggest tests mitigate potential consequences novel...
Abstract Non-absorbable polypropylene (PP) meshes have been widely used in surgical reconstruction of the pelvic floor disorders. However, they are associated with serious complications. Human acellular dermal matrices (hADM) demonstrated safety and efficacy reconstructive medicine, but their suitability at vaginal level is not known. This study compares biological performance PP mesh a newly developed hADM. 20 rabbits were randomized to receive hADM graft or mesh. Grafts surgically...
Background: Decellularized human nerves overcome the limitations of current treatments for large peripheral nerve injuries. However, use decellularized requires an "off-the-shelf" availability useful and actual clinical application. In this study, we addressed preservation native matrix in integrative approach tissue scaffold production. Materials Methods: For analysis, used histological examination immunofluorescence to examine structure, biomechanical assays evaluate tensile strength...
The preservation conditions of fresh osteochondral allografts for clinical applications are critical due their objective: to transplant mature hyaline cartilage containing viable chondrocytes, maintaining metabolic activity and also preserving the structural functional characteristics extracellular matrix. aim present study was compare fluorescence confocal microscopy flow cytometry techniques evaluate viability chondrocytes in tissue, order determine effectiveness thus ensure...
Abstract Objective : to investigate the feasibility of New Zealand White (NZW) rabbit study human acellular dermal matrix (hADM) biomaterials in pelvic reconstructive surgery. Study design 20 white female NZW rabbits were randomized into 2 groups, experimental group (hADM graft) and control (Polypropylene graft; PP). In each animal, grafts surgically implanted subcutaneously abdominal wall vaginal submucosa layer for 180 days. The graft segments then removed surgical clinical results...
Abstract Non-absorbable polypropylene (PP) meshes have been widely used in surgical reconstruction of the pelvic floor disorders. However, they are associated with serious complications. Human acellular dermal matrices (hADM) demonstrated safety and efficacy reconstructive medicine, but their suitability at vaginal level is not known. This study compares biological performance PP mesh a newly developed hADM. 20 rabbits were randomized to receive hADM graft or mesh. Grafts surgically...