A5084333994- Primary Care and Health Outcomes
- DNA Repair Mechanisms
- Ethics in Clinical Research
- Artificial Intelligence in Healthcare
- Radiology practices and education
- Radiation Dose and Imaging
- Genomics and Chromatin Dynamics
- Radioactivity and Radon Measurements
- Carcinogens and Genotoxicity Assessment
- Radiation Therapy and Dosimetry
- Healthcare cost, quality, practices
- Mitochondrial Function and Pathology
- Cardiac Health and Mental Health
- Electronic Health Records Systems
- Palliative Care and End-of-Life Issues
- Diversity and Career in Medicine
- Biomedical Text Mining and Ontologies
- PARP inhibition in cancer therapy
- Medical Coding and Health Information
- Emergency and Acute Care Studies
- Health Promotion and Cardiovascular Prevention
- CRISPR and Genetic Engineering
- Sex and Gender in Healthcare
- Global Health Workforce Issues
- Global Health Care Issues
Public Health England
2021
Macmillan Cancer Support
2021
University of Calgary
2013-2020
Cancer Institute (WIA)
2017
Google (United States)
2017
O'Brien Institute
2017
Public Health Department
2017
Abstract Human-made buildings can artificially concentrate radioactive radon gas of geologic origin, exposing occupants to harmful alpha particle radiation emissions that damage DNA and increase lung cancer risk. We examined how North American residential exposure varies by modern environmental design, occupant behaviour season. 11,727 were radon-tested using multiple approaches coupled geologic, geographic, architectural, seasonal behavioural data with quality controls. Regional residences...
Cell survival after oxidative DNA damage requires signaling, repair and transcriptional events often enabled by nucleosome displacement, exchange or removal chromatin remodeling enzymes. Here, we show that Chromodomain Helicase DNA-binding protein 6 (CHD6), distinct to other CHD enzymes, is stabilized during stress via reduced degradation. CHD6 relocates rapidly in a manner dependent upon lesions conserved N-terminal poly(ADP-ribose)-dependent recruitment motif, with later retention...
The inhalation of naturally occurring radon (222Rn) gas from indoor air exposes lung tissue to α-particle bombardment, a highly mutagenic form ionizing radiation that damages DNA and increases the lifetime risk cancer. We analyzed household concentrations factors in southern Alberta, including Calgary, third-largest Canadian metropolis.A total 2382 residential homes (2018 Calgary 364 surrounding townships) an area encompassing 82% Alberta population were tested for radon, per Health Canada...
In the last two decades, sex-related differences regarding cardiovascular diagnosis, treatment, and risk factors management have been reported. The current study aims to explore in outcomes among male female patients attending Irish secondary prevention programme - Heartwatch. This is a retrospective observational study. Anonymous data was extracted from Heartwatch database 2003 2017. Cardiovascular were analysed at sign-up four years follow-ups. An 8-point aggregate score (CCare Score)...
Objectives This study estimates the prevalence of cancers that are categorised as treatable but not curable (TbnC) in England. It provides a quantification population and framework to aid identification this group enable design tailored support services. Design Through consultation with clinical data experts an algorithmic definition TbnC was developed. Using cancer registry sets, five other linked sets held by National Disease Registration Service, algorithm applied part retrospective...
Ionizing radiation (IR) is environmentally prevalent and, depending on dose and linear energy transfer (LET), can elicit serious health effects by damaging DNA. Relative to low LET photon (X-rays, gamma rays), higher particle produces more disease causing, complex DNA damage that substantially challenging resolve quickly or accurately. Despite the majority of human lifetime IR exposure involving long-term, repetitive, doses high alpha particles (e.g. radon gas inhalation), technological...
Ethics review of research involving humans has become something an institution in recent years. It is intended to protect participants from harm and, that end, follows rigorous standards. Given changes methodologies utilized medical research, it may be ethics for some kinds studies needs reexamined. The purpose this paper stimulate dialogue regarding the kind required citizen science-based research. We describe a case study proposal submitted our board and propose different approaches...
Objective Collaborate, Analyse, Research and Audit (CARA) project set out to provide an infrastructure enable Irish general practitioners (GPs) use their routinely collected patient management software (PMS) data better understand population, disease prescribing through dashboards. This paper explains the design development of CARA infrastructure. Methods The first exemplar dashboard was developed with GPs focused on antibiotic develop showcase proposed integration process involved...
Rural communities can experience more barriers to accessing health care than their urban counterparts, largely due fewer healthcare staff and services, geographical isolation. The purpose of this study is examine the availability GP practices in rural across Mid-West Ireland potential impact practice closure on patient access.
Objectives To investigate patient follow-up data from Heartwatch: Ireland’s secondary prevention programme for cardiovascular disease delivered in general practice. Design Retrospective descriptive study based on analysis of routinely collected Heartwatch. Setting Heartwatch targeted 20% practices Ireland and recruited 475 practitioners across 325 practices. Participants The population included people with a history acute myocardial infarction, percutaneous transluminal coronary angioplasty...
Abstract Background Since winter 2020/21, general practitioners (GPs) in the Republic of Ireland (RoI) have been granted access to diagnostic imaging studies on a new publicly funded pathway, expediting services previously obtained via hospital-based doctors. Aims Outline GP perspectives “GP Access Community Diagnostics” initiative. Methods A mixed-methods design was employed. Referrals over first six months 2019 and 2021 were collated by private provider, randomly selected subset (maximum...
Currently, more than 1.6 million Irish people live rurally. Rural populations in Ireland are older and have health needs compared with younger urban areas. Meanwhile, since 1982, the proportion of general practices rural areas has decreased by 10%. In this study, we look at new survey data to investigate challenges practice Ireland.This study will make use responses from 2021 membership College General Practitioners (ICGP). The anonymous, online, was sent email ICGP late 2021, a series...
Background: Irish general practice data is commonly stored in isolated systems (Patient Management Software (PMS)). PMS supports individual patient storage but accessing and analysing aggregated information for quality improvement initiatives challenging. CARA set out to provide an infrastructure enable practitioners (GPs) use their routinely collected better understand population, disease management prescribing through dashboards. This paper explains the design development of...