A5083040357- Astronomy and Astrophysical Research
- Heart Failure Treatment and Management
- Stellar, planetary, and galactic studies
- Cardiovascular Function and Risk Factors
- Gamma-ray bursts and supernovae
- Health Systems, Economic Evaluations, Quality of Life
- Galaxies: Formation, Evolution, Phenomena
- Astrophysical Phenomena and Observations
- Mobile Health and mHealth Applications
- Astronomical Observations and Instrumentation
- Astrophysics and Star Formation Studies
- Electronic Health Records Systems
- Chronic Disease Management Strategies
- Cardiac pacing and defibrillation studies
- Pharmaceutical Practices and Patient Outcomes
- ICT in Developing Communities
- Cardiac Health and Mental Health
- Healthcare Systems and Technology
- Pneumonia and Respiratory Infections
- Patient Safety and Medication Errors
- Primary Care and Health Outcomes
- Medication Adherence and Compliance
- Diabetes Treatment and Management
- Atrial Fibrillation Management and Outcomes
- Global Health Workforce Issues
University College Dublin
2016-2025
Imperial College London
2021-2024
University of South Florida
2024
Energy Center of Wisconsin
2023
University of Limerick
2021-2023
Aberystwyth University
1992-2022
Trinity College Dublin
2005-2022
Institute of Biological, Environmental and Rural Sciences
2014-2022
Indiana University School of Medicine
2022
National University of Ireland
2018-2021
IMPORTANCEPrevention strategies for heart failure are needed.OBJECTIVE To determine the efficacy of a screening program using brain-type natriuretic peptide (BNP) and collaborative care in an at-risk population reducing newly diagnosed prevalence significant left ventricular (LV) systolic and/or diastolic dysfunction. DESIGN, SETTING, AND PARTICIPANTSThe St Vincent's Screening to Prevent Heart Failure Study, parallel-group randomized trial involving 1374 participants with cardiovascular risk...
Aims Differentiation of heart failure with reduced ( HFrEF ) or preserved HFpEF ejection fraction independent echocardiography is challenging in the community. Diagnostic strategies based on monitoring circulating microRNA miRNA levels may prove to be clinical value near future. The aim this study was identify a novel signature that could useful HF diagnostic tool and provide valuable information whether patient has . Methods results MiRNA biomarker discovery carried out three cohorts, no...
Background: Limited knowledge exists of the extent epigenetic alterations, such as DNA methylation, in heart failure (HF). We conducted targeted methylation sequencing to identify alterations coding and noncoding RNA (ncRNA) across different etiological subtypes HF. Methods Results: A bisulfite sequence capture platform was applied extracted from cardiac interventricular septal tissue 30 male HF patients encompassing causes including hypertrophic obstructive cardiomyopathy, ischemic dilated...
Early warning scores (EWS) are used to identify physiological deterioration in patients. Studies date have primarily focused on the correlation between trends serially recorded EWS of inpatients and clinical outcomes. This study examined predictive value an calculated immediately presentation hospital for acute medical patients.A prospective 225 consecutive admissions. Pulse, systolic blood pressure, respiratory rate, oxygen saturation neurological status were calculate EWS. Patients divided...
The aim of this study was to address chronic heart failure (HF) diagnosis with the application machine learning (ML) approaches. In present study, we simulated procedure that is followed in clinical practice, as models built are based on various combinations feature categories, e.g., features, echocardiogram, and laboratory findings. We also investigated incremental value each type. total number subjects utilized 422. An ML approach proposed, comprising selection, handling class imbalance,...
The purpose of this study was to investigate the utility BNP, hsTroponin-I, interleukin-6, sST2, and galectin-3 in predicting future development new onset heart failure with preserved ejection fraction (HFpEF) asymptomatic patients at-risk for HF.This is a retrospective analysis longitudinal STOP-HF thirty who developed HFpEF matched cohort that did not develop (n = 60) over similar time period. Biomarker candidates were quantified at two points prior initial diagnosis.HsTroponin-I BNP...
<ns3:p>Background Cardiovascular disease (CVD) is the leading cause of death worldwide and disproportionately affects individuals from low socioeconomic (LSE) areas. Self-management interventions in general practice targeted towards people LSE areas may positively impact patients’ health. The High Risk Prevention Programme (HRPP), developed by Ireland’s Health Service Executive (HSE), Irish Heart Foundation University College Dublin School Medicine a behavioural self-management intervention...
In the last two decades, sex-related differences regarding cardiovascular diagnosis, treatment, and risk factors management have been reported. The current study aims to explore in outcomes among male female patients attending Irish secondary prevention programme - Heartwatch. This is a retrospective observational study. Anonymous data was extracted from Heartwatch database 2003 2017. Cardiovascular were analysed at sign-up four years follow-ups. An 8-point aggregate score (CCare Score)...
Introduction AI-powered conversational agents have proven effective in alleviating psychological distress, however, concerns about autonomy and authentic development remain, especially youth during critical stages of identity resilience formation. Despite the increasing use AI technologies, there is a significant gap well-being literacy within educational systems. This leaves young adults ill-prepared to navigate complexities real world challenges, contributing rising rates anxiety, stress,...
Systemic hypertension is highly prevalent in obstructive sleep apnea (OSA) but there are limited data on OSA prevalence cohorts with comparing dippers and nondippers. We investigated this relationship a clinic-based cohort of patients who were not screened for any pretest possibility OSA.A total 100 aged (mean ± SD) 58 10 years, body mass index 30.5 6.1 kg/m2, Epworth Sleepiness Scale score 6 4 included. All underwent overnight attended studies 24-hour ambulatory blood pressure monitoring....
Abstract Aims In the PARADIGM‐heart failure trial, sacubitril‐valsartan demonstrated a reduction in heart admissions and reduced all‐cause mortality patients with ejection fraction. Although real world data have shown similar benefits regarding efficacy safety, there has been difficulty achieving target dose (TD). The factors preventing achievement of TD remains unclear. This study assesses tolerability, ability to achieve, linked attaining routine clinical population. Methods results is...
Background Atrial tissue fibrosis is linked to inflammatory cells, yet incompletely understood. A growing body of literature associates peripheral blood levels the antifibrotic hormone BNP (B‐type natriuretic peptide) with atrial fibrillation ( AF ). We investigated relationship between pro‐fibrotic M2 macrophage marker Cluster Differentiation CD )163+, procollagen expression, and gene expression in patients without . Methods Results In a cross‐sectional study design, right was procured from...
Delayed diagnosis in primary care is a common, harmful and costly patient safety incident. Its measurement monitoring are underdeveloped underutilised. We created implemented novel approach to identify problems leading solutions for delayed care. developed priority-setting method called PRIORITIZE. invited more than 500 NW London clinicians via an open-ended questionnaire three main relating 113 submitted their suggestions which were thematically grouped synthesized into composite list of 33...
Medication error is a frequent, harmful and costly patient safety incident. Research to date has mostly focused on medication errors in hospitals. In this study, we aimed identify the main causes of, solutions to, primary care. We used novel priority-setting method for identifying ranking problems called PRIORITIZE. invited 500 North West London care clinicians complete an open-ended questionnaire three relating 113 submitted responses, which thematically synthesized into composite list of...