A5101856721- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Nanoplatforms for cancer theranostics
- Collagen: Extraction and Characterization
- Reproductive biology and impacts on aquatic species
- Cell Adhesion Molecules Research
- Aquaculture Nutrition and Growth
- Advanced Nanomaterials in Catalysis
- Electrospun Nanofibers in Biomedical Applications
- Luminescence and Fluorescent Materials
- Image and Signal Denoising Methods
- Sirtuins and Resveratrol in Medicine
- Histone Deacetylase Inhibitors Research
- Adenosine and Purinergic Signaling
- Enzyme Catalysis and Immobilization
- Advanced biosensing and bioanalysis techniques
- Advanced Image Processing Techniques
- Electrochemical sensors and biosensors
- Chemical Synthesis and Analysis
- Enzyme Production and Characterization
- Nanocluster Synthesis and Applications
- Aquaculture disease management and microbiota
- Photoacoustic and Ultrasonic Imaging
- Inflammatory mediators and NSAID effects
- Calcium Carbonate Crystallization and Inhibition
- Amino Acid Enzymes and Metabolism
Beijing University of Chemical Technology
2024-2025
City University of Hong Kong
2022-2024
City University of Hong Kong, Shenzhen Research Institute
2023-2024
Lanzhou University
2018-2024
Aerospace Information Research Institute
2024
Chinese Academy of Sciences
2015-2024
State Key Laboratory of Remote Sensing Science
2024
Lanzhou Jiaotong University
2024
Dalian Ocean University
2023
Institute of Hydrobiology, Biology Centre, Academy of Sciences of the Czech Republic
2023
Lysine lactylation (Kla) is a novel histone post-translational modification discovered in late 2019. Later, HDAC1-3, were identified as the robust Kla erasers. While Sirtuin family proteins showed weak eraser activities toward Kla, reported. However, catalytic mechanisms and physiological functions of HDACs Sirtuins are not identical. In this study, we observed that SIRT3 exhibits higher activity against H4K16la site than other human Sirtuins. Crystal structures revealed detailed binding...
Abstract. Soil moisture plays a key role in vegetation restoration and ecosystem stability arid semiarid regions. The response of soil to rainfall pulses is an important hydrological process, which strongly influenced by land use during the implementation restoration. In this study, vertical variations woodland (Pinus tabulaeformis), native grassland (Stipa bungeana), shrubland (Hippophea rhamnoides), cropland (Triticum aestivum) artificial (Onobrychis viciaefolia) five profiles were...
Abstract Employing responsive nanoplatforms as carriers for photosensitizers represents an effective strategy to overcome the challenges associated with photodynamic therapy (PDT), including poor solubility, low bioavailability, and high systemic toxicity. Drawing inspiration from morphology transitions in biological systems, a general approach enhance PDT that utilizes enzyme‐responsive is developed. The transformation of phosphopeptide/photosensitizer co‐assembled nanoparticles first...
Abstract The creation of versatile platforms for developing dual‐channel near‐infrared fluorescent (NIRF) and photoacoustic (PA) probes, especially those engineered to minimize channel crosstalk, is crucial precise biomarker detection. However, such remain scarce. To bridge this gap, study introduces an innovative cyanine‐based platform, CySN . platform showcases remarkable wavelength‐shifting properties, including large modality shift (68 nm) PA (145 after the decaging reaction. These...
Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor associated with limited treatment options and high drug resistance, presenting significant challenges in the pursuit of effective strategies. Epigenetic modifications have emerged as promising diagnostic biomarkers therapeutic targets for GBM. For instance, histone deacetylase 6 (HDAC6) has been identified potential pharmacological target Furthermore, overexpression monoamine oxidase A (MAO A) glioma linked to...
Red-tail catfish (Hemibagrus wyckioides) is an important commercially farmed in southern China. Males of red-tail grow faster than females, suggesting that all-male will produce more significant economic benefits aquaculture practice. However, little research has been reported on sex determination and gonadal development catfish.In this study, we performed the first transcriptomic analysis male female gonads at four developmental stages 10, 18, 30, 48 days post hatching (dph) using RNA-seq...
Abstract Along with an ever‐deepening understanding of the catalytic principle natural enzymes, rational design high‐activity biomimetic nanozymes has become a hot topic in current research. Inspired by active centers enzymes consisting sites and binding pockets, Cu‐doped CoS 2 hollow nanocube (Cu/CoS HNCs) nanozyme integrating substitution defects vacancies is developed through defect engineering strategy. It shown that Cu/CoS HNC serve as pockets sites, respectively. The construction this...
Chemoselective modification of specific residues within a given protein poses significant challenge, as the microenvironment amino acid in proteins is variable. Developing universal molecular platform with tunable chemical warheads can provide powerful tools for precisely labeling acids proteins. Cysteine and lysine are hot targets chemoselective modification, but current cysteine/lysine-selective face challenges due to cross-reactivity unstable reaction products. In this study, versatile...
With the development of ecological civilization construction, urban planning and in China have entered a phase which optimizing constructing spaces is required. As national livable city, Xuchang has experienced rapid economic recent years, leading to significant expansion that impacted layout space networks central area its surroundings. Therefore, identifying spatial corridors City are crucial for park city construction. This study utilizes multisource geospatial data identify extract City....
Abstract The efficient detection of pathological collagen plays an essential role in the diagnosis, prognosis, and treatment various critical diseases such as arthritis tumors. Peptide probes with (Gly‐Pro‐Hyp)n sequences have been recently discovered to recognize collagen; however, their staining efficacy severely suffers from strong trimerizing tendency. An intrinsically nontrimerizing peptide probe F‐GOP‐10 has constructed for first time specifically target collagen. consists repetitive...
Financial time series prediction has been a challenge due to its uninterpreted patterns, dynamics and noises. With machine learning, the objective of predicting trends foreign exchange rate can be achieved by building neural networks. In this paper, we propose novel Multi-Channel LSTM network for utilizing information from different scales. Features extracted channels provide complementary they are used jointly predict trends. We applied our model on real market data EURUSD EURAUD evaluate...
Two novel peptide probes provide versatile tools for specifically targeting denatured collagen in various types of connective tissues, which has attractive potential the diagnosis and therapeutics collagen-involved diseases.
The construction of potent peptide probes for selectively detecting denatured collagen is crucial a variety widespread diseases. However, all the collagen-targeting found till date primarily utilized repetitive (Gly-X-Y)n sequences with exclusively imino acids Pro and Hyp in X Y positions, which stabilized triple helical conformation probes, resulting severe obstacles their clinical applications. A novel series have been constructed by incorporating nonimino at position (GPO)3GXO(GPO)4...
Trypsin not only acts as a novel robust biotemplate to mediate the growth of CaCO<sub>3</sub> crystals, but also enhances their biological properties an excellent enzyme.
The red swamp crayfish (Procambarus clarkii) is an important aquatic animal and has developed as a popular aquaculture species in China. In this study, total of 72,839 SSR motifs were identified from transcriptional data, 20 microsatellite markers them finally to assess the genetic diversities seven wild populations natural lakes nine cultured rice fields. Genetic diversity was slightly higher than populations. degree differentiation between slight, while moderate large most variations...
Catfish (Siluriformes) are one of the most diverse vertebrate orders and characterized by whisker-like barbels, which important sensory organs in teleosts. However, their specific biological functions still unclear. Red-tail catfish (Hemibagrus wyckioides) is well-known species with four pairs maxillary barbels reach two-thirds body length. In this study, a 776.58 Mb high-quality chromosome-level genome was assembled into 29 chromosomes. Comparative data indicated that barbeled regeneration...
Optical coherence tomography (OCT) is an emerging optical imaging modality with high resolution and non-invasive, which plays important role in applications such as material detection disease diagnosis, especially for ophthalmic retinal diseases age-related macular degeneration, diabetic edema choroidal neovascularization. However, since OCT utilizes the coherent interference of light, generated image inevitably affected by speckle noise, blurs structural information layer structure lesion...
The development of robust collagen assays is crucial in the diagnosis and treatment various pathological conditions. Peptide probes composed (Gly-Pro-Hyp)n sequences have received extensive attention for their remarkable collagen-targeting capability, which unfortunately has been severely impaired by high triple helical stability. Herein, we report an efficient strategy to reduce propensity electrostatic repulsion. A series peptides consisting (Gly-Pro-Hyp)7 sequence a number charged amino...
Dynamically controlling the post-translational modification of ε-amino groups lysine residues is critical for regulating many cellular events. Increasing studies have revealed that important diseases, including cancer and neurological disorders, are associated with malfunction deacylases demethylases. Developing fluorescent probes capable detecting deacylase demethylase activity highly useful interrogating their roles in epigenetic regulation diseases. Due to distinct substrate recognition...
Abstract Proteases, such as trypsin, are essential for extracting collagen in various industrial applications. The potential applications of rare earth nanomaterials, specifically yttrium nanoparticles, have attracted significant interest across fields due to their distinctive characteristics, including high dielectric constant and thermal stability. Biomineralization has emerged a promising approach synthesize protein-inorganic nanomaterials with hierarchical structures desired functions....