A5080649849- Pesticide Residue Analysis and Safety
- Pharmaceutical and Antibiotic Environmental Impacts
- Antibiotics Pharmacokinetics and Efficacy
- Analytical chemistry methods development
- Antibiotic Resistance in Bacteria
- Pharmacological Effects and Assays
- Coccidia and coccidiosis research
- Biosensors and Analytical Detection
- Plant Toxicity and Pharmacological Properties
- Effects and risks of endocrine disrupting chemicals
- Food Safety and Hygiene
- Insect and Pesticide Research
- Bee Products Chemical Analysis
- Pneumonia and Respiratory Infections
- Veterinary medicine and infectious diseases
- Antibiotic Use and Resistance
- Milk Quality and Mastitis in Dairy Cows
- Environmental and biological studies
- Infant Nutrition and Health
- Healthcare Regulation
- Cancer and biochemical research
- Botanical Research and Chemistry
- Analytical Methods in Pharmaceuticals
- Bacterial Infections and Vaccines
- Food Science and Nutritional Studies
Fundação Oswaldo Cruz
2013-2024
Faculdades Oswaldo Cruz
2022
Instituto Nacional de Saúde
2018-2021
The occurrence of antimicrobials in the aquatic environment and drinking water has raised question their impact on public health. Animal production is one most expressive activities Brazilian agribusiness. In order to ensure productivity competitiveness sector, use drugs for therapeutic prophylactic purposes a common practice. Due continuous release into environment, aim this study was compare frequency detection tetracyclines sulfonamides surface collected from rural areas Lidice District...
Two analytical methods for determination of five antibiotics classes in surface water and drinking samples were developed validated based on solid phase extraction followed by high-performance liquid chromatography coupled to tandem mass spectrometry.Two distinct chromatographic gradients used according the polarity different pharmaceuticals.The applied quantification 46 analytes belonging beta-lactams, macrolides, fluoroquinolones, sulfonamides tetracyclines classes.Validation results...
A simple extraction technique has been developed for seven macrolide antibiotics in milk. The procedure involves a modified quick, easy, cheap, effective, rugged, and safe method based on acetonitrile extraction, followed by the addition of mixture salts (sodium sulfate, sodium chloride, potassium carbonate) not yet reported literature. was validated tylosin selective, free matrix effect, linear range 0.78–18.75 ng/mL final extract, corresponding to 0.125–3 times maximum residue limit. limit...
This pilot survey aimed to assess the occurrence of tetracyclines and 4-epimers oxytetracycline, tetracycline chlortetracycline in commercial pasteurized milks sold metropolitan area Rio de Janeiro, Brazil, between October 2009 March 2010. A liquid chromatography-tandem mass spectrometry (LC-MS/MS) method, developed validated our laboratory, was used. All 100 analyzed samples were compliant, but 14 contained oxytetracycline concentrations ranging from method limit detection (3.7 µg l(-1))...
A segurança de alimentos é um tema cada vez mais relevante, devido à crescente busca por uma melhor qualidade vida e conscientização dos consumidores quanto ao direito adquirir produtos seguros saúde. O uso substâncias em animais produtores para o consumo humano requer estudos farmacocinética depleção resíduos, com estabelecimento valores limitativos, forma que não constituam risco Além das utilizadas intencionalmente, outras advindas da contaminação ambiental ou rações ingeridas esses podem...
A simple, rapid and sensitive screening method by liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed for the identification of 7 macrolides (clarithromycin, erythromycin, oleandomycin, spiramycin, tilmicosin, troleandomycin tylosin) 8 quinolones (ciprofloxacin, difloxacin, enrofloxacin, flumequine, moxifloxacin, nalidixic acid, norfloxacin ofloxacin) in meat egg-based baby foods. Sample preparation performed using an alkaline modified QuEChERS (Quick, Easy, Cheap,...
Considering the widespread use of antibiotic monensin (MON) in Brazilian livestock and possibility residues milk, this paper aimed to study stability fate drug during production Minas Frescal cheese, its effects on milk fermentation physicochemical characteristics product. For that, samples raw were fortified with MON at three different nominal concentrations (1.0, 2.0 8.0 μg/kg), passed through heat treatment used produce cheese. Pasteurization efficiency was certified by alkaline...
Antibiotic resistance genes (ARGs) are widespread in the environment due to overuse of antibiotics and other pollutants, posing a threat human animal health. In this study, we evaluated antimicrobial residues, bacterial diversity ARGs two important watersheds, Guandu São João, that supply drinking water Rio de Janeiro city, Brazil. addition, tap samples were collected from three different cities State, including metropolitan area city. Clarithromycin, sulfamethoxazole azithromycin found...
Two extraction/clean-up analytical procedures were investigated and compared regarding their recovery matrix-purification efficiency for screening β2-agonist residues in fortified bovine urine by high-resolution gas chromatography-mass spectrometry (GC-MS). The first procedure, based on an method originally developed detecting anabolic steroids, consists of the employment nonionic resin, Amberlite® XAD-2, a styrene-divinylbenzene copolymer solid-phase extraction (SPE), followed liquid-liquid...
A liquid chromatography–tandem mass spectrometry (LC–MS/MS) method, which has recently been developed and validated, was used for the identification quantification of polyether ionophore, macrolide lincosamide residues in commercial eggs sold metropolitan area Rio de Janeiro, Brazil. The method applied to 100 samples results showed a high incidence ionophore (25%). Salinomycin detected 21% samples, but only two non-compliant (5.3 53 µg kg−1) were found if maximum limits (tolerances)...
This narrative literature review deals with the honey, its context as a product of varied uses and significant socio-economic relevance, aiming to describe some emerging chemical residues contaminants their aspects related Health Surveillance. Honey is substance that, beyond being used food since beginning human civilization, also has therapeutic pharmacothecnical applications. Brazil among major world producers exporters honey this production play relevant role in country. Like other...
Polyether ionophore antibiotics are used in cattle to promote growth, increase milk production lactating cows, and prevent treat coccidiosis. In Brazil, lasalocid monensin the two polyether ionophores that allowed as antimicrobial additives dairy cow feed. However, there few methods for determining residues of these milk, no monitoring data available Brazil. These not yet included residue control programs matrix implemented by National Sanitary Surveillance Agency Ministry Agriculture,...
Tetracyclines and polyether ionophores are veterinary drugs frequently used in animals reared for food production. Despite the benefits, residues can be harmful human health if levels higher than those considered safe. The aim of this study was to evaluate, by LC-MS/MS, tetracyclines pasteurised milk samples marketed São Paulo state, Brazil estimate exposure adult/adolescent/children population. Within eight antibiotics monitored two were detected, tetracycline 4-epitetracycline, found 22.5%...