A5041343168- Venous Thromboembolism Diagnosis and Management
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Transplantation: Methods and Outcomes
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Blood Coagulation and Thrombosis Mechanisms
- Viral-associated cancers and disorders
- Hepatocellular Carcinoma Treatment and Prognosis
- Gallbladder and Bile Duct Disorders
- Blood disorders and treatments
- Liver Disease and Transplantation
- Childhood Cancer Survivors' Quality of Life
- Extracellular vesicles in disease
- Heparin-Induced Thrombocytopenia and Thrombosis
- Hematopoietic Stem Cell Transplantation
- Immune cells in cancer
- Metastasis and carcinoma case studies
- Pancreatitis Pathology and Treatment
- Gyrotron and Vacuum Electronics Research
- Protease and Inhibitor Mechanisms
- Cancer survivorship and care
- Bone and Joint Diseases
- Total Knee Arthroplasty Outcomes
- Atherosclerosis and Cardiovascular Diseases
- Immunotherapy and Immune Responses
- Neuroendocrine Tumor Research Advances
Methodist Hospital
2025
Methodist Hospital
2025
Roswell Park Comprehensive Cancer Center
2018-2021
University of North Carolina at Chapel Hill
2018-2019
University at Buffalo, State University of New York
2016-2017
Pancreatic cancer is associated with a high incidence of venous thromboembolism. Neutrophils have been shown to contribute thrombosis in part by releasing neutrophil extracellular traps (NET). A recent study showed that increased plasma levels the NET biomarker, citrullinated histone H3 (H3Cit), are thromboembolism patients pancreatic and lung but not those other types cancer, including breast cancer. In this study, we examined contribution neutrophils nude mice bearing human tumors. We...
Abstract Pancreatic cancer patients have a high risk of venous thromboembolism (VTE). Plasminogen activator inhibitor 1 (PAI-1) inhibits plasminogen activators and increases the thrombosis. PAI-1 is expressed by pancreatic tumors human cell lines. However, to date, there are no studies analyzing association active VTE in patients. We investigated plasma In addition, we determined if presence expressing impairs thrombus resolution mice. Plasma levels with mice bearing were enzyme-linked...
Background. Hepatocellular carcinoma (HCC) has a rising incidence and mortality in North America. Liver transplantation (LT) with adjunctive therapies offers excellent outcomes. However, HCC recurrences are associated high mortality. We investigate whether adjuvant systemic therapy can reduce recurrence, as shown other malignancies. Methods. Medical records of patients undergoing LT for at single center between January 2016 December 2022 were retrospectively reviewed. Patients stratified...
Background. Perihilar cholangiocarcinoma (phCCA) has excellent outcomes following liver transplantation (LT). Neoadjuvant radiation-based locoregional therapy is standard-of-care. Gemcitabine and cisplatin (gem/cis) combination systemic therapies have improved in advanced settings, but their efficacy pre-LT not been studied. Methods. We review our experience neoadjuvant gem/cis alone versus approaches. Patients with phCCA undergoing LT at a single center between January 2008 February 2023...
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, with treatment failure largely driven by stem-like cells that resist conventional chemoradiation and subsequently initiate tumor recurrence. While immune checkpoint blockade is effective in microsatellite instability-high (MSI-H) CRCs, the majority CRCs are stable (MSS) exhibit exclusion, rendering them refractory to immunotherapy. Here, we identify previously uncharacterized cell subtype, which term cancerous Crypt...
HCT co-morbidity index (HCT-CI) is a valid predictor of TRM and OS, however it has not been tested with other outcomes. KPS more subjective definition but also shows functional impairment independently associated shorter OS post HCT. We HCT-CI, the results comprehensive physical performance assessment pre-HCT day+100 TRM, novel outcomes LOS, death during admission, readmission need for rehabilitation placement after discharge. 349 consecutive adult (≥18 years) patients had first allogeneic...
Introduction: Cancer patients have an increased risk of venous thromboembolism (VTE) compared with healthy individuals. Pancreatic cancer has one the highest rates VTE. We are interested in elucidating pathways that contribute to cancer-associated thrombosis (CAT) particularly pancreatic cancer. A recent study reported association between plasma levels citrullinated histone H3, a marker neutrophil extracellular traps (NETs), and VTE population variety cancer-types. Importantly, subgroup...
Poor physical functioning is associated with adverse outcomes after allogeneic hematopoietic cell transplantation (alloHCT). Analytic tools to predict mortality in alloHCT recipients include the HCT Comorbidity Index (HCT-CI) based on comorbidities and Disease Risk (DRI) disease status. We developed replicated a risk model for overall survival (OS), early (ie, death from any cause at or before day +100), initial hospital length of stay (LOS), percentage inpatient days within first year...
Introduction: There is growing evidence that metabolic intermediates and products can modulate inflammatory responses. Acute pancreatitis (AP) affects more than 200,000 people each year in the United States. A hallmark of AP frequent rapid progression into a severe response which associated with pancreatic necrosis multi-organ failure. The ability non-infectious insults to initiate inflammation poorly understood feature AP, clinical management currently limited supportive care Aims: To Test...