A5025986237- Neurogenesis and neuroplasticity mechanisms
- Genetics and Neurodevelopmental Disorders
- Neuroscience and Neuropharmacology Research
- Wnt/β-catenin signaling in development and cancer
- Alzheimer's disease research and treatments
- Axon Guidance and Neuronal Signaling
- MicroRNA in disease regulation
- Intracerebral and Subarachnoid Hemorrhage Research
- Epilepsy research and treatment
- Memory and Neural Mechanisms
- Neurological Disease Mechanisms and Treatments
- Cancer-related gene regulation
- Neuroinflammation and Neurodegeneration Mechanisms
Universidad Andrés Bello
2016-2024
Institute of Biomedical Science
2023-2024
Indiana University School of Medicine
2022-2024
Indiana University – Purdue University Indianapolis
2022-2024
Indiana University
2022
Neurological Surgery
2022
In the adult hippocampus new neurons are continuously generated from neural stem cells (NSCs) present at subgranular zone of dentate gyrus. This process is controlled by Wnt signaling, which plays a complex role in regulating multiple steps neurogenesis including maintenance, proliferation and differentiation progenitor development newborn neurons. Differential effects signaling during progression could be mediated cell-type specific expression receptors. Here we studied potential Frizzled-1...
Dendrite arbor growth, or dendritogenesis, is choreographed by a diverse set of cues, including the NMDA receptor (NMDAR) subunits NR2A and NR2B. While NR1NR2B receptors are predominantly expressed in immature neurons promote plasticity, NR1NR2A mainly mature induce circuit stability. How different regulate these processes unclear, but this likely related to presence their distinct C-terminal sequences that couple signaling proteins. Calcium-calmodulin-dependent protein kinase II (CaMKII) an...
Mesial temporal lobe epilepsy (mTLE) is a life-threatening condition characterized by recurrent hippocampal seizures. mTLE can develop after exposure to risk factors such as febrile seizure, trauma, and infection. Within the latent period between onset of epilepsy, pathological remodeling events occur that contribute epileptogenesis. The molecular mechanisms responsible are currently unclear. We used mouse intrahippocampal kainite model investigate transcriptional dysregulation in...
Abstract In Alzheimer´s disease (AD) there is a reduction in hippocampal neurogenesis that has been associated to cognitive deficits. Previously we showed Andrographolide (ANDRO), the main bioactive component of Andrographis paniculate , induces proliferation hippocampus APPswe/PSEN1ΔE9 (APP/PS1) mouse model AD as assessed by staining with mitotic marker Ki67. Here, further characterized effect ANDRO on APP/PS1 mice and evaluated contribution this process ANDRO. Treatment 8-month-old for 4...
Abstract Background Close to 80 90% of subjects with AD also present cerebral amyloid angiopathy (CAA) a disease in which accumulation damages the vasculature an impairs blood flow. Since current therapies are targeting focusing on amyloid, we interested determine how decrease observed CAA and our aim is impact tau reduction pathogenesis. Method We crossed Tg‐FDD mice model Mapt ‐/‐ levels analyzed pathogenesis different genotypes though behavioral tests, histological morphometric assays...
In the dentate gyrus of adult hippocampus, neurogenesis from neural stem cells (NSCs) is regulated by Wnt signals local microenvironment. The Wnt/β-catenin pathway active in NSCs, where it regulates proliferation and fate commitment, subsequently its activity strongly attenuated. mechanisms controlling are poorly understood. peripheral tissues, secreted R-spondin proteins (RSPO1-4) interact with LGR4-6 receptors control signaling strength. Here, we found that RSPO1-3 expressed cultured NSCs...
In the dentate gyrus of adult hippocampus, neurogenesis from neural stem cells (NSCs) is regulated by Wnt signals local microenvironment. The Wnt/β-catenin pathway active in NSCs, where it regulates proliferation and fate commitment, subsequently its activity strongly attenuated. mechanisms controlling this pattern are poorly understood. peripheral tissues, secreted R-spondin proteins (RSPO1-4) interact with LGR4-6 receptors control signaling strength. Here, we found that RSPO1-3 expressed...
Abstract Mesial Temporal lobe epilepsy (mTLE) is a life-threatening condition characterized by recurrent epileptic seizures initiating in the hippocampus. mTLE can develop after exposure to risk factors such as seizure, trauma, and infection. Within latent period between onset of seizures, pathological remodeling events occur which are believed contribute epileptogenesis. The molecular mechanisms responsible for epileptogenesis seizure network currently unclear. We used mouse...