Jianfei Chen

ORCID: 0000-0002-6786-9283
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About
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Research Areas
  • Angiogenesis and VEGF in Cancer
  • Neuroscience of respiration and sleep
  • Immune Cell Function and Interaction
  • Immunotherapy and Immune Responses
  • Cardiovascular Function and Risk Factors
  • Pulmonary Hypertension Research and Treatments
  • Cancer, Hypoxia, and Metabolism
  • Immune cells in cancer
  • Immune Response and Inflammation
  • Cardiac Imaging and Diagnostics
  • Connective Tissue Growth Factor Research
  • Mesenchymal stem cell research
  • Heart Rate Variability and Autonomic Control
  • Microbial infections and disease research
  • Eicosanoids and Hypertension Pharmacology
  • Liver physiology and pathology
  • Hormonal Regulation and Hypertension
  • Toxoplasma gondii Research Studies
  • High Altitude and Hypoxia
  • Inflammatory mediators and NSAID effects
  • T-cell and B-cell Immunology
  • Fatty Acid Research and Health
  • Acute Ischemic Stroke Management
  • CAR-T cell therapy research
  • Biomarkers in Disease Mechanisms

Army Medical University
2009-2024

Xinqiao Hospital
2010-2024

Putian University
2019

Brigham and Women's Hospital
2015

Harvard University
2015

Peking University People's Hospital
2010

Peking University
2010

Morusin has been traditionally used for the treatment of Mycoplasma pneumoniae pneumonia (MPP), but underlying mechanism remains elusive. The present study aimed to explore by which morusin achieves efficacy on mycoplasma pneumonia. model was established in BALB/c mouse and effects were evaluated model. Compared with group, DNA amount M. decreased 24.6 ± 3.14% 47.6 6.78% low (20 mg/kg) high (50 groups, respectively (P<0.05). Moreover, led levels pro-inflammatory cytokines such as interleukin...

10.1042/bsr20190190 article EN Bioscience Reports 2019-06-01

Sleep disturbances and psychiatric repercussions pose great challenges at high altitude; however, few studies have investigated sleep disturbance anxiety profiles their associations after acute exposure in consecutive patients. Thus, we aimed to study the of patients high-altitude association such with anxiety. A total 668 participants were recruited sea level 3700 m. The trials performed (1 week prior a 2-h flight destination) m (24, 72, 168 h). assessed by self-reported patterns scores on...

10.1038/s41398-019-0510-x article EN cc-by Translational Psychiatry 2019-07-22

Although Streptococcus pneumoniae is usually found as a commensal in healthy individuals, it can act pathogen trauma patients, causing such complications early-onset pneumonia and sepsis. We discovered that treating mice with an A-class CpG-oligodeoxynucleotide (ODN) at 2 h after traumatic injury significantly improved mouse survival following secondary lung infection S. pneumoniae. This study used mass cytometry (cytometry by time-of-flight) Luminex technologies to characterize the cellular...

10.4049/jimmunol.1500597 article EN The Journal of Immunology 2015-12-17

Aim: To identify the predictive role of triglyceride-glucose (TyG) index in pulmonary hypertension (PH) coronary artery disease (CAD) patients after percutaneous intervention (PCI) treatment.

10.1080/17520363.2024.2422807 article EN cc-by-nc-nd Biomarkers in Medicine 2024-11-20

Objectives To explore the effect of c-met overexpression in EPCs on reendothelialisation after balloon injury. Methods derived from mouse bone marrow were isolated and cultured. 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assays used to evaluate EPC proliferation. Adenoviral vector expressing c-Met was generated using AdEasy system. role HGF/Met vascular repair vivo, we balloon-injured rat carotid artery model. Evans Blue dye administered 10 days injury, neointimal formation...

10.1136/heartjnl-2013-304613.149 article EN Heart 2013-08-01

Abstract Aim To identify the predictive role of TyG index for onset pulmonary hypertension in patients with coronary artery disease (CAD) who underwent percutaneous intervention (PCI) treatment. Methods We performed this prospective cohort study among CAD received PCI treatment our center from July 2016 to October 2022. The baselines echocardiography at both cross-sections and blood biomarkers. A angiography operation was also performed. Within a median 4.5 years follow-up, measure their...

10.1101/2023.02.21.23286276 preprint EN medRxiv (Cold Spring Harbor Laboratory) 2023-02-24
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