A5100460361- Enzyme Catalysis and Immobilization
- Electrochemical sensors and biosensors
- Ionic liquids properties and applications
- Advanced Cellulose Research Studies
- Microtubule and mitosis dynamics
- Electrospun Nanofibers in Biomedical Applications
- biodegradable polymer synthesis and properties
- Lignin and Wood Chemistry
- Algal biology and biofuel production
- Analytical Chemistry and Chromatography
- Natural product bioactivities and synthesis
- Enzyme-mediated dye degradation
- Plant Pathogens and Fungal Diseases
- Microbial Metabolic Engineering and Bioproduction
- Biofuel production and bioconversion
- Ubiquitin and proteasome pathways
- Protein Hydrolysis and Bioactive Peptides
- Cellular transport and secretion
- Adsorption and biosorption for pollutant removal
- Photosynthetic Processes and Mechanisms
- Cancer-related Molecular Pathways
- Genomics and Chromatin Dynamics
- Pharmacological Effects of Medicinal Plants
- Conducting polymers and applications
- Aldose Reductase and Taurine
Chonnam National University
2014-2025
Konkuk University
2015-2024
Hanmi Pharmaceutical (South Korea)
2024
University of Minnesota
2024
Korea Forest Service
2013-2020
Government of the Republic of Korea
2019
Inje University
2014-2019
Korea University
2018
Duke-NUS Medical School
2014-2018
Cornell University
2018
Lignocellulose represents a key sustainable source of biomass for transformation into biofuels and bio-based products. Unfortunately, lignocellulosic is highly recalcitrant to biotransformation, both microbial enzymatic, which limits its use prevents economically viable conversion value-added As result, effective pretreatment strategies are necessary, invariably involves high energy processing or results in the degradation components lignocellulose. In this work, ionic liquid,...
The Hildebrand solubility parameters, cohesive energy densities and internal energies of 1-alkyl-3-methylimidazolium-based room temperature ionic liquids were determined by the intrinsic viscosity method their dependencies on length alkyl group analyzed.
The mitotic arrest-deficient protein Mad1 forms a complex with Mad2, which is required for imposing arrest on cells in the spindle assembly perturbed. By mass spectrometry of affinity-purified Mad2-associated factors, we identified translocated promoter region (Tpr), component nuclear pore (NPC), as novel Mad2-interacting protein. Tpr directly binds to and Mad2. Depletion HeLa disrupts NPC localization Mad2 during interphase decreases levels Mad1-bound Furthermore, depletion at kinetochores...
NAD-dependent formate dehydrogenase (FDH) from Candida boidinii (CbFDH) has been widely used in various CO2-reduction systems but its practical applications are often impeded due to low CO2-reducing activity. In this study, we demonstrated superior properties of FDH Thiobacillus sp. KNK65MA (TsFDH) for production CO2 gas. To discover more efficient FDHs than a reference enzyme, i.e. CbFDH, five were selected with biochemical and then, their activities evaluated. All including CbFDH showed...
BUBR1 is a mitotic phosphoprotein essential for the maintenance of chromosome stability by promoting congression and proper kinetochore-microtubule (K-fiber) attachment, but underlying mechanism(s) has remained elusive. Here we identify as binding partner B56 family Protein Phosphatase 2A regulatory subunits. The interaction between required congression, since point mutations in that block abolish congression. BUBR1:B56-PP2A complex opposes Aurora B kinase activity, loss can be reverted...
Recently, natural sun blockers have been drawing considerable attention because synthetic UV filters could adverse effects not only on humans but also the environment. Even though lignin, second most abundant renewable resource earth, is a UV-absorbing polymer, its unfavorable dark color hampers applications in sunscreens. In this work, we obtained light-colored lignin (CEL) from rice husks through cellulolytic enzyme treatment and subsequent solvent extraction under mild conditions compared...
Protein phosphatase 2A (PP2A) accounts for the majority of total Ser/Thr activities in most cell types and regulates many biological processes. PP2A holoenzymes contain a scaffold A subunit, catalytic C one regulatory/targeting B subunits. How subunit controls localization substrate specificity, which is crucial aspect regulation, remains poorly understood. The kinetochore critical site functioning, where orchestrates chromosome segregation through its interactions with BubR1. PP2A-BubR1...
Achieving robust cancer-specific lethality is the ultimate clinical goal. Here, we identify a compound with dual-inhibitory properties, named a131, that selectively kills cancer cells, while protecting normal cells. Through an unbiased CETSA screen, PIP4K lipid kinases as target of a131. Ablation PIP4Ks generates phenocopy pharmacological effects inhibition by Notably, a131 causes reversible growth arrest in cells transcriptionally upregulating PIK3IP1, suppressor PI3K/Akt/mTOR pathway....
The chromosome passenger complex (CPC) must relocate from anaphase chromosomes to the cell equator for successful cytokinesis. Although this landmark event requires mitotic kinesin MKlp2, spatiotemporal mechanistic basis remains elusive. Here, we show that phosphoregulation of MKlp2 by kinase Cdk1/cyclin B1 coordinates proper transition with CPC relocation. We identified multiple phosphorylation sites within stalk and C-terminal tail inhibit microtubule binding bundling,...