A5020550358- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Liver Disease Diagnosis and Treatment
- Diet and metabolism studies
- Migration, Health and Trauma
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Emergency and Acute Care Studies
- Cancer, Lipids, and Metabolism
- Food Security and Health in Diverse Populations
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Liver Disease and Transplantation
- COVID-19 and healthcare impacts
- Cancer-related molecular mechanisms research
- Tissue Engineering and Regenerative Medicine
- Nitric Oxide and Endothelin Effects
- Metabolomics and Mass Spectrometry Studies
- Transplantation: Methods and Outcomes
- Ion channel regulation and function
- Metabolism and Genetic Disorders
- High Altitude and Hypoxia
- Xenotransplantation and immune response
- Cardiac Ischemia and Reperfusion
- Diet, Metabolism, and Disease
- Pluripotent Stem Cells Research
Minneapolis Heart Institute Foundation
2023-2024
Twin Cities Orthopedics
2023-2024
University of Minnesota
2023-2024
Baylor College of Medicine
2024
University of Minnesota Medical Center
2024
Inflammation drives pulmonary arterial hypertension (PAH). Gut dysbiosis causes immune dysregulation and systemic inflammation by altering circulating microbial metabolites; however, little is known about gut metabolites in PAH.
Mitochondrial dysfunction, characterized by impaired lipid metabolism and heightened reactive oxygen species generation, results in peroxidation ferroptosis. Ferroptosis is an inflammatory mode of cell death that promotes complement activation macrophage recruitment. In pulmonary arterial hypertension (PAH), endothelial cells exhibit cellular phenotypes promote Moreover, there ectopic deposition accumulation the vasculature. However, effects ferroptosis inhibition on these pathogenic...
BackgroundKetone bodies are pleotropic metabolites that play important roles in multiple biological processes ranging from bioenergetics to inflammation regulation via suppression of the NLRP3 inflammasome, and epigenetic modifications. Ketone elevated left ventricular failure (LVF) approaches increase ketone concentrations exert advantageous cardiac effects rodents humans. However, relationships between right (RVF) relatively unexplored.Methods51 PAH patients were dichotomized into...
Abstract Background Mitochondrial dysfunction, characterized by impaired lipid metabolism and heightened reactive oxygen species (ROS) generation, results in peroxidation ferroptosis. Ferroptosis is an inflammatory mode of cell death that promotes complement activation macrophage recruitment. In pulmonary arterial hypertension (PAH), endothelial cells (PAEC) exhibit cellular phenotypes promote Moreover, there ectopic deposition accumulation the vasculature. However, effects ferroptosis...
Abstract Emerging data demonstrate systemic and local inflammation regulate right ventricular (RV) adaption in preclinical human pulmonary arterial hypertension (PAH). Pathological RV is targetable as antagonism of glycoprotein-130 (GP130) signaling counteracts pathological microtubule remodeling improves function rodents. Microtubules control several aspects cardiomyocyte biology including cellular nuclear size/structure, t-tubule homeostasis, the proper localization connexin-43. The...
Ketone bodies are pleotropic metabolites that play important roles in multiple biological processes ranging from bioenergetics to inflammation regulation via suppression of the NLRP3 inflammasome, and epigenetic modifications. elevated left ventricular failure (LVF) approaches increase ketone concentrations exert advantageous cardiac effects rodents humans. However, relationships between right (RVF) relatively unexplored. Moreover, cardioprotective properties ketones preclinical RVF unknown....
Background: Valine, leucine, and isoleucine are the branched amino acids (BCAA). Elevated BCAAs predict worse outcomes in several cardiovascular diseases with metabolic origins, but role of pulmonary arterial hypertension (PAH) remains unclear. Moreover, effects on emerging lung-liver axis unexplored. Methods: The small molecule (BT2) activation BCAA catabolism a low diet were evaluated monocrotaline rats. Multi-omics analyses lung liver conducted BT2 arm. Confocal microscopy hepatocyte...
Introduction: Right ventricular failure (RVF) is the leading cause of death in pulmonary arterial hypertension (PAH), but effective therapies for RVF are lacking. Ketones exert therapeutic effects through suppression NLRP3 (nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3) inflammasome and exhibit favorable metabolic properties LVF. However, relationships among serum ketone bodies, RV activation, function preclinical human unexplored. Hypothesis: Serum...
Introduction: Valine, leucine, and isoleucine are essential branched chain amino acids (BCAA), recent epidemiological studies report elevated BCAAs predict worse outcomes in several cardiovascular diseases with metabolic origins such as diabetes, heart failure, hypertension. However, the role of BCAA metabolism pulmonary arterial hypertension pathophysiology is relatively unexplored. Hypothesis: human PAH reduction via small molecule activation catabolism dietary interventions combats...
ABSTRACT Objectives To measure changes in cause of death dynamics 2019 and 2020 the relationship between concurrent occurrence COVID-19 pandemic mortality outcome by race ethnicity. Patients Methods We used resident data from Minnesota Department Health (MDH) to conduct retrospective statistical analysis deaths relative assess a pre-pandemic period. Results strongly contributed ethnicity-related disparities Minnesota. Not only was there greater proportion decedents within Black Hispanic...
Introduction: Microtubules (MTs) are crucial for cardiomyocyte function as they regulate t-tubule structure, nuclear morphology, and gap junction protein localization. Glycoprotein-130 (GP130) signaling promotes pathological MT remodeling right ventricular (RV) dysfunction in pulmonary arterial hypertension (PAH), but the trigger inflammation-MT connection is unknown. Microbiome dysbiosis activates systemic inflammation, levels of anti-inflammatory bacteria Lactobacillus associated with RV...
Introduction: Pulmonary arterial hypertension (PAH) patients exhibit sexual dimorphism in pulmonary vascular remodeling and right ventricular (RV) dysfunction. While female PAH have severe remodeling, male worse RV function. Inflammation, a key component of pathobiology, has been implicated as potential mechanism for dimorphism. Gut dysbiosis causes systemic inflammation. However, it is unknown whether gut contributes to PAH. Hypothesis: There are sex-specific differences the microbiome...