A5025029318- Food Allergy and Anaphylaxis Research
- Gut microbiota and health
- Pulmonary Hypertension Research and Treatments
- Liver Disease and Transplantation
- Clostridium difficile and Clostridium perfringens research
- Cancer-related molecular mechanisms research
- Eosinophilic Esophagitis
- Allergic Rhinitis and Sensitization
- Microscopic Colitis
- Liver Disease Diagnosis and Treatment
- Gastrointestinal motility and disorders
- Inflammatory Bowel Disease
- Plant Virus Research Studies
- Respiratory viral infections research
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Transgenic Plants and Applications
- Esophageal and GI Pathology
- Metabolomics and Mass Spectrometry Studies
- Mycobacterium research and diagnosis
- Tissue Engineering and Regenerative Medicine
- Gallbladder and Bile Duct Disorders
- Cardiovascular Health and Risk Factors
- Abdominal vascular conditions and treatments
- Contact Dermatitis and Allergies
- Infant Health and Development
Minneapolis VA Health Care System
2024-2025
University of Minnesota
2021-2025
Minneapolis VA Medical Center
2025
University of Minnesota System
2025
Texas Tech University
2024
Texas Tech University Health Sciences Center
2024
Ohio Department of Transportation
2021-2022
Biotechnology Institute
2021
University of Colorado Denver
2011-2017
University of Colorado Hospital
2017
Inflammation drives pulmonary arterial hypertension (PAH). Gut dysbiosis causes immune dysregulation and systemic inflammation by altering circulating microbial metabolites; however, little is known about gut metabolites in PAH.
Background Intermittent fasting (IF) confers pleiotropic cardiovascular benefits including restructuring of the gut microbiome and augmentation cellular metabolism. Pulmonary arterial hypertension (PAH) is a rare lethal disease characterized by right ventricular (RV) mitochondrial dysfunction resultant lipotoxicity dysbiosis. However, effects IF on RV function in PAH are unexplored. Therefore, we investigated how altered microbiota composition, function, survival monocrotaline model PAH....
Reliable engraftment assessment of donor microbial communities and individual strains is an essential component characterizing the pharmacokinetics microbiota transplant therapies (MTTs). Recent methods for measuring use whole-genome sequencing reference databases or metagenome-assembled genomes (MAGs) to track bacterial but lack ability disambiguate DNA that matches both patient microbiota. Here, we describe a new, cost-efficient analytic pipeline, MAGEnTa, which compares post-MTT samples...
Peanut allergy (PNA) has been reported to be transferred tolerant recipients through organ and bone marrow (BM) transplantation. The roles T B cells play in establishing, the cell subsets maintaining lifelong anti-peanut IgE levels are unknown.To determine cellular requirements for transfer of murine PNA role CD20(+) long-lived levels.We developed a novel adoptive model investigate transferring PNA. We also treated peanut-allergic (PA) mice with anti-CD20 antibody measured throughout...
Abstract Background and Aims Microbiota transplant therapy (MTT) is an emerging treatment for ulcerative colitis (UC). One proposed mechanism the benefit of MTT through engraftment donor microbiota; however, kinetics are unknown. We identified SourceTracker as efficient method both to determine kinetic study engrafting taxa aid in determining how this may treat UC. Methods Ulcerative patients received either encapsulated (drug name MTP-101C) or placebo capsules daily 8 weeks followed by a...
Abstract Emerging data demonstrate systemic and local inflammation regulate right ventricular (RV) adaption in preclinical human pulmonary arterial hypertension (PAH). Pathological RV is targetable as antagonism of glycoprotein-130 (GP130) signaling counteracts pathological microtubule remodeling improves function rodents. Microtubules control several aspects cardiomyocyte biology including cellular nuclear size/structure, t-tubule homeostasis, the proper localization connexin-43. The...
Mycobacterium chimaera , a member of the avium complex, is slow-growing, nontuberculous mycobacterium associated with outbreaks in cardiac-surgery patients supported on heart-lung machines. We report case an elderly woman chronic prednisone who presented six-month history worsening back pain, recurrent low-grade fevers, and weight loss. Imaging identified multilevel vertebral osteomyelitis lumbar soft-tissue abscess. Abscess culture M. .
<b><i>Background:</i></b> Anti-peanut immunoglobulin E (anti-Pn IgE) can persist throughout life, suggesting that this condition could be maintained by long-lived antibody-secreting cells (ASCs). To determine the role of ASCs, peanut-allergic mice underwent prolonged treatment with proteasome inhibitor, bortezomib (Bz). <b><i>Methods:</i></b> Intravenous Bz was given twice weekly for 21 weeks to mice. During treatment, serum anti-Pn IgE...
Introduction: Inflammation plays a mechanistic role in pulmonary arterial hypertension (PAH); however, what triggers inflammation remains unclear. Hypothesis: PAH is characterized by gut dysbiosis and barrier dysfunction, leading to an altered burden of circulating microbial metabolic products, promoting disease. We aimed characterize the microbiome products healthy controls patients. Methods: The V4 hypervariable region 16S rRNA gene was analyzed from fecal samples 40 57 Plasma for...