A5011377295- Epigenetics and DNA Methylation
- Genetics and Neurodevelopmental Disorders
- Child Abuse and Trauma
- RNA modifications and cancer
- Migration, Health and Trauma
- Genomics and Chromatin Dynamics
- Cancer Genomics and Diagnostics
- Genetic factors in colorectal cancer
- Adolescent Sexual and Reproductive Health
- DNA Repair Mechanisms
- Molecular Biology Techniques and Applications
- Chromosomal and Genetic Variations
- Intimate Partner and Family Violence
- Congenital heart defects research
- Telomeres, Telomerase, and Senescence
LabCorp (United States)
2024-2025
National Institute on Aging
2021-2024
University of Baltimore
2023
Institute on Aging
2023
University of South Florida
2020-2022
National Institutes of Health
2022
Epigenetic alterations are a key hallmark of aging but have been limitedly explored in tissues. Here, using naturally aged murine liver as model and extending to other quiescent tissues, we find that is driven by temporal chromatin promote refractory cellular state compromise identity. Using an integrated multi-omics approach the first direct visualization chromatin, globally, old cells show H3K27me3-driven broad heterochromatinization transcriptional suppression. At local level,...
Cardiovascular disease (CVD) is the leading cause of mortality and morbidity for all sexes, racial ethnic groups. Age, its associated physiological pathological consequences, exacerbate CVD incidence progression, while modulation biological age with interventions track cardiovascular health. Despite strong link between aging CVD, surprisingly few studies have directly investigated heart failure vascular dysfunction in aged models subjects. Nevertheless, correlations been found disease,...
Intimate partner violence (IPV) is a significant public health issue with detrimental consequences for women's reproductive, mental, and physical health. In Haiti, IPV major obstacle to development. Yet, the determinants of victimization are still not well understood. this study, we utilized 2016-2017 Haiti Demographic Health Survey determine prevalence its subtypes (emotional, physical, sexual abuse) among married or cohabiting women (N = 3,805) reproductive age (15-49) by their current...
Abstract DNA hydroxymethylation (5hmC), the most abundant oxidative derivative of methylation, is typically enriched at enhancers and gene bodies transcriptionally active tissue-specific genes. Although aberrant genomic 5hmC has been implicated in age-related diseases, its functional role aging remains unknown. Here, using mouse liver cerebellum as model organs, we show that accumulates associated with function restricts magnitude expression changes age. Mechanistically, decreases binding...
3063 Background: To help guide treatment decisions and enable clinical trial matching for cancer patients, tumor genomic profiling is an essential precision oncology tool. Liquid biopsy may be used as a complementary approach to assess tumor-specific DNA alterations circulating in the blood. The Labcorp Plasma Complete test next-generation-sequencing (NGS), cell-free (cfDNA) comprehensive that identifies actionable clinically relevant variants advanced metastatic solid cancers across 521...
Epigenetic alterations are a key hallmark of aging but have been limitedly explored in tissues. Here, using naturally aged murine liver as model and extending to other quiescent tissues, we find that is driven by temporal chromatin promote refractory cellular state compromise identity. Using an integrated multi-omics approach, the first direct visualization globally, old cells show H3K27me3-driven broad heterochromatinization transcription suppression. At local level, site-specific loss...
DNA hydroxymethylation (5hmC), the most abundant oxidative derivative of methylation, is typically enriched at enhancers and gene bodies transcriptionally active tissue-specific genes. Although aberrant genomic 5hmC has been implicated in age-related diseases, its functional role aging remains unknown. Here, using mouse liver cerebellum as model organs, we show that accumulates associated with function restricts magnitude expression changes age. Mechanistically, decreases binding splicing...
Abstract Background The mechanisms through which exposure to differing trauma types become biologically embedded shape the risk for subsequent post-traumatic stress disorder (PTSD) is unclear. DNA methylation (5-mC), particularly in stress-relevant genes, may play a role this relationship. Methods We conducted path analysis using generalized structural equation modeling investigate whether blood-derived 5-mC Nuclear Factor of Activated T Cells 1 ( NFATC1 ) mediated prospective association...