A5028842875- Maternal and Perinatal Health Interventions
- Maternal and fetal healthcare
- Cholesterol and Lipid Metabolism
- Monoclonal and Polyclonal Antibodies Research
- Global Cancer Incidence and Screening
- Lipoproteins and Cardiovascular Health
- Pharmacogenetics and Drug Metabolism
- Biosimilars and Bioanalytical Methods
- Colorectal Cancer Screening and Detection
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Antioxidant Activity and Oxidative Stress
- Pelvic floor disorders treatments
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Peroxisome Proliferator-Activated Receptors
- Cancer, Lipids, and Metabolism
- Drug Transport and Resistance Mechanisms
- Statistical Methods in Clinical Trials
- Health Systems, Economic Evaluations, Quality of Life
- COVID-19 Impact on Reproduction
- Gene expression and cancer classification
- Biochemical Acid Research Studies
- Anorectal Disease Treatments and Outcomes
- Foot and Ankle Surgery
- Viral Infectious Diseases and Gene Expression in Insects
Bristol-Myers Squibb (Switzerland)
2024
Royal College of Obstetricians and Gynaecologists
2021-2023
London School of Hygiene & Tropical Medicine
2015-2023
Faculty of Public Health
2021-2022
University College London
2019-2021
MRC Clinical Trials Unit at UCL
2020-2021
Technical University of Darmstadt
2021
Comprehensive Clinical Trials
2019
Novartis (Switzerland)
2009-2018
Cancer Research UK
2015
Background The COVID-19 pandemic has disrupted maternity services worldwide and imposed restrictions on societal behaviours. This national study aimed to compare obstetric intervention pregnancy outcome rates in England during the corresponding pre-pandemic calendar periods, assess whether differences these varied according ethnic socioeconomic background. Methods findings We conducted a of singleton births English National Health Service hospitals. compared period (23 March 2020 22 February...
We provide an up-to-date international comparison of cancer survival, assessing whether England is 'closing the gap' compared with other high-income countries.
B-cell depletion with rituximab is commonly used for patients systemic lupus erythematosus (SLE) that refractory to conventional therapy, but it yields variable responses. We hypothesized high activating factor (BAFF) levels after can cause disease flares, thereby limiting its effectiveness.To obtain preliminary evidence efficacy of the anti-BAFF therapeutic belimumab in SLE.Phase 2, randomized, double-blind (patients, assessors, researchers, care providers), placebo-controlled,...
Die autologe Chondrozytentransplantation oder -implantation (ACT/ACI) stellt ein anerkanntes und etabliertes Verfahren zur Behandlung lokalisiert vollschichtiger Knorpelschäden des Kniegelenks dar. vorliegende Übersichtsarbeit der Arbeitsgemeinschaft "Klinische Geweberegeneration" Deutschen Gesellschaft für Orthopädie Unfallchirurgie (DGOU) beschreibt zunächst die Biologie Funktionsweise gesunden Gelenkknorpels, aktuelle Kenntnislage zu den möglichen Folgen eines primären Knorpelschadens...
Pregnant women with pre-existing mental illnesses have increased risks of adverse obstetric and neonatal outcomes compared pregnant without illnesses. We aimed to estimate these differences in according the highest level pre-pregnancy specialist health care, defined as psychiatric hospital admission, crisis resolution team (CRT) contact, or community care only, timing most recent episode 7 years before pregnancy. Hospital birth registration records singleton births between April 1, 2014,...
Few treatment options exist for patients with systemic lupus erythematosus (SLE) who fail conventional therapy. Although widely used to treat lupus, the efficacy of B cell depletion therapy using rituximab has not been demonstrated in randomised clinical trials. Following rituximab, elevated levels serum activating factor (BAFF) have associated failure remit or subsequent relapse. The administration belimumab, a monoclonal antibody specific BAFF and approved therapy, could potentiate enable...
A single-nucleotide polymorphism (3'322C/G) was identified in the gene encoding a key cholesterol/triglyceride regulator, sterol-regulatory element-binding protein 1c (SREBP-1c). Although it did not alter amino acid sequence, SREBP-1c-3'322C/G predictive of highly active antiretroviral therapy-related hyperlipoproteinaemia. Increases cholesterol were less frequently associated with homozygous SREBP-1c-3'322G (genotype 22) than heterozygous/homozygous SREBP-1c-3'322C (genotypes 11/12) and...
Background A syndrome characterized by hypertriglyceridaemia, hypercholesterolaemia, hyperinsulinaemia, and lipodystrophy has been found to be associated with highly active antiretroviral treatment (HAART) including protease inhibitors. marker predicting this previously identified in the gene encoding sterol-regulatory element-binding protein (SREBP)-1c, a regulator of triglycerides, cholesterol, insulin, adipocytes. Objective possible inhibition SREBP-1c-dependent genes inhibitor indinavir...
Background Ethnic and socioeconomic inequalities in obstetric outcomes are well established. However, the role of induction labour (IOL) to reduce these is controversial, part due insufficient evidence. This national cohort study aimed identify adverse perinatal associated with IOL birth at 39 weeks gestation (“IOL group”) compared expectant management (“expectant according maternal characteristics women low-risk pregnancies. Methods findings All English National Health Service (NHS)...
Human cells maintain their cholesterol homeostasis by regulated cleavage of membrane bound transcription factors, so-called sterol regulatory element binding proteins (SREBPs). If are deprived cholesterol, SREBPs cleaved two proteolytic steps. The NH<sub>2</sub>-terminal domain the is released from membranes endoplasmic reticulum and transported into nucleus, where it binds to specific nucleotide sequences in promoters low density lipoprotein receptor gene key genes involved triglyceride...
To assess the association between hospital-level rates of induction labour and emergency caesarean section, as measures "practice style", adverse perinatal outcomes.
A key component of recent English cancer policy is the monitoring trends in early diagnosis cancer. Early can be defined by disease stage at or other indicators derived from electronic health records. We evaluate association between different and survival, discuss implementation surveillance diagnosis. searched PubMed database grey literature to identify their with survival. analysed registrations for 355,502 patients diagnosed England during period 2009–2013, quantified each indicator...
The increasing complexity of surgical patients and working time constraints represent challenges for training. In this study, the European Association Cardio-Thoracic Surgery Residents' Committee aimed to evaluate satisfaction with current training programmes across Europe.We conducted an online survey between October 2018 April 2019, completed by a total 219 participants from 24 countries.The average respondent was in fourth or fifth year training, mostly on cardiac surgery pathway. Most...
Abstract Background The total ankle replacement versus arthrodesis (TARVA) trial aims to determine which surgical procedure confers the greatest improvement in pain-free function for patients with end-stage osteoarthritis. Both procedures are effective but there has not yet been a direct comparison establish is superior. This article describes statistical analysis plan this as an update published protocol. It written prior end of patient follow-up, while outcome still unknown. Design and...