A5000230184- Advanced Polymer Synthesis and Characterization
- Supramolecular Self-Assembly in Materials
- Chemical Synthesis and Analysis
- Luminescence and Fluorescent Materials
- biodegradable polymer synthesis and properties
- Synthetic Organic Chemistry Methods
- Dendrimers and Hyperbranched Polymers
- Protein Structure and Dynamics
- Synthesis and properties of polymers
- Photopolymerization techniques and applications
- Silicone and Siloxane Chemistry
- Nanoparticle-Based Drug Delivery
- Biopolymer Synthesis and Applications
- Click Chemistry and Applications
- Nanoplatforms for cancer theranostics
- Graphene and Nanomaterials Applications
- Hydrogels: synthesis, properties, applications
- Glycosylation and Glycoproteins Research
- Polymer Surface Interaction Studies
- Catalytic Cross-Coupling Reactions
- Epoxy Resin Curing Processes
- Supramolecular Chemistry and Complexes
- Photochromic and Fluorescence Chemistry
- Carbon dioxide utilization in catalysis
- Advanced Battery Technologies Research
University of Illinois Urbana-Champaign
2014-2022
Johnson Controls (United States)
2018
Urbana University
2014-2017
University of Connecticut
2017
Significance Biomacromolecules are synthesized in cells with high precision, although the cellular environment contains numerous molecules and species other than building blocks. In contrast, even state-of-the-art chemical synthesis of macromolecules is exclusively carried out under a specific condition containing only clean, essential starting materials to minimize side reactions. Inspired by ribozyme-catalyzed protein synthesis, we report here controlled polypeptide nonpurified N...
Cooperative interactions and transitions are among the most important strategies utilized by biological systems to regulate a variety of physical chemical processes. We report herein an auto-accelerated, rapid cooperative polymerization N-carboxyanhydrides (NCAs) with initiators structurally as simple linear aliphatic diamines for synthesis polypeptides. The initiated proceeds via formation "hinged" polypeptides, which two blocks helical chains connected head-to-head diamine molecules in...
Polypeptide micelles are widely used as biocompatible nanoplatforms but often suffer from their poor structural stability. Unimolecular polypeptide can effectively address the structure instability issue, synthesis with uniform and well-controlled desired sizes remains challenging. Herein we report convenient preparation of spherical unimolecular through dendritic polyamine-initiated ultrafast ring-opening polymerization N-carboxyanhydrides (NCAs). Synthetic polypeptides exceptionally high...
Enzymes provide optimal three-dimensional structures for substrate binding and the subsequent accelerated reaction. Such folding-dependent catalytic behaviors, however, are seldom mechanistically explored with reduced structural complexity. Here, we demonstrate that α-helix, a much simpler motif of enzyme, can facilitate its own growth through self-catalyzed polymerization N-carboxyanhydride (NCA) in dichloromethane. The reversible between N terminus α-helical polypeptides NCAs promotes rate...
Abstract Synthetic polypeptides have received increasing attention due to their ability form higher ordered structures similar proteins. The control over secondary structures, which enables dynamic conformational changes, is primarily accomplished by tuning the side-chain hydrophobic or ionic interactions. Herein we report a strategy modulate conformation of utilizing donor–acceptor interactions emanating from H-bonding ligands. Specifically, 1,2,3-triazole groups, when incorporated onto...
Water-soluble, acrylate-terminated poly(β-amino esters) with built-in trigger-responsive domains were synthesized through Michael addition of diacrylates and primary amines. They used as macromolecular precursors for photoinitiated cross-linking reactions to prepare hydrogels protein encapsulation. The encapsulated proteins could be rapidly released upon external triggering.
Multilamellar membranes are important building blocks for constructing self-assembled structures with improved barrier properties, such as multilamellar lipid vesicles. Polymeric vesicles (polymersomes) have attracted growing interest, but polymersomes much less explored. Here, we report the formation of polypeptide unprecedented densely packed multilayer membrane poly(ethylene glycol)-block-poly(γ-(4,5-dimethoxy-2-nitrobenzyl)-l-glutamate) (PEG-b-PL), an amphiphilic diblock rod-coil...
Hydrosilylation is one of the most ubiquitous reactions in silicone chemistry, used to make and cure a variety products that consumers interact with on daily basis. A longstanding complication this reaction propensity platinum catalysts isomerize terminal alkenes internal are far less reactive toward hydrosilylation. Here, we demonstrate appropriate choice Si–H substrate control over conditions, these isomers can be reisomerized alkene then undergo hydrosilylation Karstedt's catalyst, an...
Alternating polymerization of norbornene containing polyesters and their functionalization.
We report the synthesis and characterization of high-molecular weight poly(<sc>l</sc>-glutamic acid) based brush polymers.
Surfactant-resistant polymersomes have substantial potential to be used as delivery vehicles in industrial applications. Herein, we report the preparation of poly(ethylene oxide)-block-polystyrene copolymers with ultrahigh hydrophobic-block molecular weights through RAFT dispersion polymerization, which allows polymerization-induced self-assembly into well-defined ultrathick membranes up ∼47 nm. These significantly enhance resistance against surfactant solubilization vesicles, improving...
A UV-responsive polymer was prepared via condensation polymerization of 2-nitrobenzyl(4-(1,2-dihydroxyethyl)phenyl)carbamate and azalaic acid dichloride. When the irradiated with UV light, nitrobenzyl urethane protecting group removed deprotected aniline underwent spontaneous 1,6-elimination reactions, resulting in degradation polymer. Nanoparticles encapsulated Nile Red were formulated degradable triggered burst release observed when nanoparticles by light. © 2015 Wiley Periodicals, Inc. J....
Using synthetic polypeptides as a model system, the theories of helix–coil transition were developed into one most beautiful and fruitful subjects in macromolecular science. The classic models proposed by Schellman Zimm–Bragg more than 50 years ago, differ assumption on whether configuration multiple helical sequences separated random coil sections is allowed longer polypeptide chain. Zimm also calculated critical chain lengths that facilitate such interrupted helices different solvent...
The objective of this project is to develop a load forecasting technique and demand management algorithm using the Model Predictive Control (MPC). This paper will demonstrate present state art with respect control strategies within market place, taxonomy such algorithms their respective strengths weaknesses. uses two-part forecaster where deterministic part exponentially weighted moving average (EWMA) model accounts for longer term trends second order regression (AR2) short variations. be...
The dynamic assembly of actin and tubulin microfilaments from their subunits is imperative in enabling cell motility, division, organismal muscle function. nucleation-controlled growth kinetics that characterizes these protein polymerizations facilitated by the cooperative reversible noncovalent interactions subunits. Although this has been realized supramolecular polymerization numerous synthetic molecules, it rare covalent since a binding event between monomer polymer must also lead to...
A liquid ROMP based thermosetting resin is developed which undergoes slow polymerization at room temperature and rapid elevated temperatures.
Model-based studies on helix–coil transition and folding cooperativity of synthetic polypeptides have contributed to the understanding protein stability development polypeptide-based functional materials. Polypeptide-containing macromolecules with complex architectures, however, remain a challenge in model-based analysis. Herein, modified Schellman–Zimm–Bragg model has been utilized quantitatively analyze polypeptide-containing macromolecules. While homopolypeptides (e.g.,...
Abstract Review: overview of smart chemistry developed and utilized in the last 5—10 years polymer‐based drug delivery nanomedicine; 506 refs.