A5011562943- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Catalytic C–H Functionalization Methods
- Molecular spectroscopy and chirality
- Axial and Atropisomeric Chirality Synthesis
- Asymmetric Synthesis and Catalysis
- Cyclopropane Reaction Mechanisms
- Chemical synthesis and alkaloids
- Catalytic Alkyne Reactions
- Asymmetric Hydrogenation and Catalysis
- Bone Metabolism and Diseases
- Chemical Reactions and Isotopes
- Radical Photochemical Reactions
- Perovskite Materials and Applications
- Carcinogens and Genotoxicity Assessment
- Synthesis and Catalytic Reactions
- Analytical Chemistry and Chromatography
- Antimicrobial agents and applications
- Optical properties and cooling technologies in crystalline materials
- Synthesis and Reactivity of Heterocycles
- CRISPR and Genetic Engineering
- Synthesis of Organic Compounds
- Sphingolipid Metabolism and Signaling
- Pharmacogenetics and Drug Metabolism
- Phytoestrogen effects and research
National University of Singapore
2022-2024
Tianjin University
2022-2024
China Pharmaceutical University
2024
Guiyang Medical University
2023
Key Laboratory of Chemistry for Natural Products of Guizhou Province and Chinese Academy of Sciences
2023
Anhui Medical University
2019
Shenyang Pharmaceutical University
2008-2009
Abstract Cyclopropanes are structural motifs that widely present in natural products and bioactive molecules, they also tremendously useful building blocks synthetic organic chemistry. Asymmetric synthesis of cyclopropane derivatives has been an intensively researched area over the years, but efficient asymmetric preparation alkylcyclopropane scaffolds remains a challenging topic. Herein, we report nickel‐hydride‐catalyzed enantioselective diastereoselective hydroalkylation cyclopropenes for...
The C-N axially chiral N-arylpyrrole motifs are privileged scaffolds in numerous biologically active molecules and natural products, as well ligands/catalysts. Asymmetric synthesis of N-arylpyrroles, however, is still challenging, the simultaneous creation contiguous axial central chirality remains unknown. Herein, a diastereo- atroposelective N-arylpyrroles enabled by light-induced phosphoric acid catalysis has been developed. key transformation one-pot, three-component oxo-diarylation...
Heterocyclic scaffolds are commonly found in numerous biologically active molecules, therapeutic agents, and agrochemicals. To probe chemical space around heterocycles, many powerful molecular editing strategies have been devised. Versatile C-H functionalization allow for peripheral modifications of heterocyclic motifs, often being specific taking place at multiple sites. The past few years seen the quick emergence exciting "single-atom skeletal editing" strategies, through one-atom deletion...
Axially chiral molecular scaffolds are widely present in therapeutic agents, natural products, catalysts, and advanced materials. The construction of such molecules has garnered significant attention from academia industry. catalytic asymmetric synthesis axially biaryls, along with other non-biaryl molecules, been extensively explored the past decade. However, atroposelective C-O axial chirality remains largely underdeveloped. Herein, we document a copper-catalyzed compounds using novel...
Abstract Chiral α,α‐diaryl ketones are structural motifs commonly present in bioactive molecules, and they also valuable building blocks synthetic organic chemistry. However, catalytic asymmetric synthesis of bearing a tertiary stereogenic center remains largely unsolved. Herein, we report de novo enantioselective from simple alkynes via chiral phosphoric acid (CPA) catalysis. A broad range enolizable prepared good yields with excellent enantioselectivities. The described protocol serves as...
Abstract Chiral aldehydes containing a tertiary stereogenic center are versatile building blocks in organic chemistry. In particular, such structural motifs bearing an α,α‐diaryl moiety very challenging scaffolds and their efficient asymmetric synthesis is not reported. this work, phosphoric acid‐catalyzed enantioselective of from simple terminal alkynes presented. This approach yields wide range highly enolizable good with excellent enantioselectivities. Facile transformations the products,...
Abstract Cyclopropanes are structural motifs that widely present in natural products and bioactive molecules, they also tremendously useful building blocks synthetic organic chemistry. Asymmetric synthesis of cyclopropane derivatives has been an intensively researched area over the years, but efficient asymmetric preparation alkylcyclopropane scaffolds remains a challenging topic. Herein, we report nickel‐hydride‐catalyzed enantioselective diastereoselective hydroalkylation cyclopropenes for...
Abstract The development of simple‐to‐operate methods for the preparation indolizidine derivatives are great importance. A mild one‐pot protocol [3+2] cycloaddition isoquinolinium/pyridinium ylides and electron‐deficient alkenes using NaBH 3 CN as reductant has been developed. a broad substrate scope (more than 40 examples) provides various novel hexahydroindolizidine in high yields excellent diastereoselectivities (up to >20/1).
Bacterial fatty acid synthase system is a well validated target for the development of novel antimicrobial agents. This study reports synthesis Schiff bases and their reductive N-benzylanilines. Most N-benzylanilines were active against Gram-positive bacteria, among which compound 4k performed best both S. aureus MRSA with MIC value at 0.5 mg/L. Moreover, we identified strong antibacterial activity 19 clinical strains isolated from different specimen, indicated its potential in application....
Abstract Chiral α,α‐diaryl ketones are structural motifs commonly present in bioactive molecules, and they also valuable building blocks synthetic organic chemistry. However, catalytic asymmetric synthesis of bearing a tertiary stereogenic center remains largely unsolved. Herein, we report de novo enantioselective from simple alkynes via chiral phosphoric acid (CPA) catalysis. A broad range enolizable prepared good yields with excellent enantioselectivities. The described protocol serves as...