A5080522571- Silk-based biomaterials and applications
- Electrospun Nanofibers in Biomedical Applications
- Bone Tissue Engineering Materials
- Natural product bioactivities and synthesis
- Cancer, Lipids, and Metabolism
- Protein Hydrolysis and Bioactive Peptides
- Oral and gingival health research
- Angiogenesis and VEGF in Cancer
- Reproductive Physiology in Livestock
- NF-κB Signaling Pathways
- melanin and skin pigmentation
- Biopolymer Synthesis and Applications
- Inflammatory mediators and NSAID effects
- Cellular Mechanics and Interactions
- biodegradable polymer synthesis and properties
- Dental Implant Techniques and Outcomes
- Bone and Dental Protein Studies
- Edible Oils Quality and Analysis
- Wound Healing and Treatments
- Dental materials and restorations
- Immune Response and Inflammation
- Polymer Surface Interaction Studies
- Effects of Environmental Stressors on Livestock
- PI3K/AKT/mTOR signaling in cancer
- Graphene and Nanomaterials Applications
Sapienza University of Rome
2017-2021
Magna Graecia University
2021
Wound healing is a dynamic process that can be seriously delayed by many factors including infectious complications. The development of dressings with intrinsic wound activity and/or releasing bioactive compounds may help addressing such an issue. In this study, hyaluronic acid (HA) at different percentages (1–35%) was used to modify chitosan (CS) biological and physico-chemical properties in order obtain 2D-matrices able promote protect from infection. HA incorporation the CS matrix...
Liquid fibrinogen is an injectable platelet concentrate rich in platelets, leukocytes, and obtained by blood centrifugation. The aim of this study was to analyze the release different growth factors liquid at times assess possible correlations between cell counts. concentration transforming factor beta 1 (TGF-β1), platelet-derived factor-AB (PDGF-AB), factor-BB (PDGF-BB), bone morphogenetic protein 2 (BMP-2), fibroblast (FGF-2) vascular endothelial (VEGF) released were examined with ELISA...
Tissue engineering is a highly interdisciplinary field of medicine aiming at regenerating damaged tissues by combining cells with porous scaffolds materials. Scaffolds are templates for tissue regeneration and should ensure suitable cell adhesion mechanical stability throughout the application period. Chitosan (CS) biocompatible polymer investigated scaffold preparation but suffers from poor strength. In this study, graphene oxide (GO) was conjugated to chitosan two weight ratios 0.3% 1%,...
Pegbovigrastim is a commercial long-acting analog of bovine granulocyte colony-stimulating factor (rbG-CSF) that promotes the increased count and functionality polymorphonuclear cells in dairy cows around time parturition. We hypothesized pegbovigrastim administered to periparturient at approximately seven days before parturition within 24 hours after calving could affect profiles gene networks involved leukocyte function. Blood was collected on Day 3 from treated groups (pegbovigrastim...
The ultraviolet (UV) component of solar radiation is the driving force life on earth, but it can cause photoaging and skin cancer. In this study, we investigated effects glucosamine-derivative 2-(N-Acetyl)-L-phenylalanylamido-2-deoxy-β-D-glucose (NAPA) human primary fibroblasts (FBs) stimulated in vitro with environmental levels UVB radiation. FBs were irradiated 0.04 J cm-2 dose, which resulted a mild dosage as shown by cell viability ROS production measurement. This dose induced activation...
Cell culture is usually performed in 2D polymer surfaces; however, several studies are conducted with the aim to screen functional coating molecules find substrates more suitable for cell adhesion and proliferation. The of this manuscript compare cytoskeleton organization different types on surfaces. Human primary fibroblasts, chondrocytes osteoblasts isolated from patients undergoing surgery were seeded polystyrene, poly-d-lysine-coated glass titanium carbide slides left grow days. Then...
The glucosamine derivative 2-(N-Acetyl)-L-phenylalanylamido-2-deoxy-β-D-glucose (NAPA), was shown to inhibit the kinase activity of IKKα, one two catalytic subunits IKK complex, decreasing inflammatory status in osteoarthritis chondrocytes. In present work we have investigated inhibition mechanism IKKα by NAPA combining computational simulations, vitro assays and Mass Spectrometry (MS) technique. assay conducted using a recombinant IKKtide, 20 amino acid peptide substrate derived from IkBα...
Objective: The aim of the present study was to investigate how different extravirgin olive oils (EVOOs), obtained by blending Olea europea cultivars, could influence cell growth, response inflammatory stimuli, and oxidative stress in a culture osteosarcoma line Saos-2.Methods: Three were physicochemically characterized, determining free acidity, oxidation status, polyphenols content, antioxidative activity. Moreover, effects on Saos-2 determined, studying mRNA expression level real-time...
The aim of this ex vivo study was to assess the ability remove oral biofilm by different combinations mechanical and chemical treatments on smooth rough titanium surfaces, as well their impact osteoconduction.Forty-eight sandblasted acid-etched (SLA) 48 machined disks were contaminated with bacterial exposed following treatments: (1) brush (TB), (2) TB + 40% citric acid (CA), (3) 5.25% sodium hypochlorite (NaOCl), (4) air polishing glycine powder (AP), (5) AP CA, (6) NaOCl. Residual bacteria...
During the last decade interest for mesenchymal cells is growing due to their possible uses in therapies treat certain degenerative pathologies. Mesenchymal stem have been found bone marrow and they shown be responsible repair fat production. stromal can obtained from a wide variety of tissues addition differentiate into many other cell types. The study differentiation programming provides new models drug discovery therapy that now overcomes gene therapy. Senescence, cancer development...