A5050800122- Anesthesia and Sedative Agents
- Airway Management and Intubation Techniques
- Tracheal and airway disorders
- Anesthesia and Pain Management
- Traumatic Brain Injury and Neurovascular Disturbances
- Pharmacological Effects and Toxicity Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Anesthesia and Neurotoxicity Research
- Hemodynamic Monitoring and Therapy
- Intensive Care Unit Cognitive Disorders
- Glioma Diagnosis and Treatment
- Voice and Speech Disorders
- Cholinesterase and Neurodegenerative Diseases
- Optical Imaging and Spectroscopy Techniques
- Epilepsy research and treatment
- Pain Management and Opioid Use
- Treatment of Major Depression
- Gastroesophageal reflux and treatments
- Ultrasound in Clinical Applications
- Electroconvulsive Therapy Studies
- Peroxisome Proliferator-Activated Receptors
- Enhanced Recovery After Surgery
- Thermal Regulation in Medicine
- Respiratory Support and Mechanisms
- Pediatric Pain Management Techniques
Copenhagen University Hospital
2011-2025
Rigshospitalet
2012-2025
Herlev Hospital
2012-2015
Centre for Sight
2013
University of Copenhagen
2011-2013
Hudklinikken
2010
Succinylcholine is usually metabolized quickly by the butyrylcholinesterase enzyme (BChE) but genetic variants of BChE may prolong duration action. The Kalow (K) variant most common mutation in gene (BCHE), being present 25% Caucasians. significance K-variant for action succinylcholine has not been well studied. Our hypothesis was that would be prolonged patients heterozygous genotype compared with normal (wild-type).We included 70 adult surgical who received 1 mg/kg rapid sequence...
Summary Background: Propofol–remifentanil anesthesia is widely used in adults but few studies are available infants. We aimed at comparing the hemodynamic effects of propofol–remifentanil vs sevoflurane–fentanyl anesthesia. In addition, we sought to investigate recovery and whether remifentanil induced acute opioid tolerance. Methods: total, 39 infants 4–6 months old were prospectively enrolled randomized receive either a combination propofol ( n = 17) or 22) for surgical repair cleft lip...
Background Tracheal intubation may cause vocal fold damage. The trial was designed to assess laryngeal morbidity comparing the E ndoflex ® tube with a conventional endotracheal stylet. We hypothesised that within first 24 h after extubation would be lower than stylet because of less rigidity. Methods This randomised included 130 elective surgical patients scheduled for general anaesthesia intubation. Pre‐ and post‐operative assessment hoarseness, pathology, voice analysis using M...
New laryngoscopes have become available for use in small children. The aim of the study was to compare Storz® videolaryngoscope (SVL) Airtraq® Optical laryngoscope (AOL) tracheal intubation children younger than two years age who had a normal airway assessment. Our hypothesis that SVL would better success rate AOL.Ten aged 2 or scheduled elective cleft lip/palate surgery were included. anesthesia standardized and Cormack-Lehane (CL)-score obtained using Macintosh laryngoscope. After...
Abstract Hyperlactatemia is common during tumor craniotomy, but the underlying pathophysiology unclear. This study measured simultaneous arterial and jugular‐bulb lactate concentrations in patients undergoing brain craniotomy to investigate hypothesis that hyperlactatemia was associated with a net cerebrovascular input. In 20 patients, blood collected hourly from start of surgery 6 h postoperatively for measurement lactate, glucose, oxygen concentration. For each marker, data were analyzed...
Background: The induction dose of hypnotic agents should be reduced in the elderly, but it is not well studied whether thiopental or propofol preferred this group patients. aim study was to compare onset time, hypnosis level and haemodynamic response after vs. for anaesthesia. Our primary hypothesis that had a shorter time than propofol, defined as bispectral index (BIS) <50. Methods: In randomized double-blinded study, we included 78 Patients were eligible, if they scheduled elective...
Acute and persistent pain after surgery is well described. However, no large-scale studies on immediate postoperative in the operating room (OR) exist, hindering potential areas of research to improve clinical outcomes. Thus, we aimed describe occurrence severity a large, unselected cohort.This was prospective cohort study, encompassing all procedures 31 public hospitals Danish Realm, during 5-day period including weekend. Data anesthesia were collected main outcome moderate or severe OR....
Abstract Aim An increasing number of children undergo magnetic resonance imaging requiring anesthesia or sedation to ensure their immobility; however, may increase body temperature whereas decrease it. We investigated changes in who underwent for imaging. Methods Children aged 12 weeks–12 years undergoing and were included this prospective observational study. Tympanic was measured before after imaging, the difference between measurements calculated. Associations patient‐ procedure‐related...
Oxygen supply to the brain is of special importance during intracranial surgery because it may be compromised by pathology. A high arterial blood pressure (mean above 80 mmHg) and a oxygen tension (PaO2 12 kPa) therefore often targeted in these patients, when for example increased or mass effect on tissue from tumour present, pursued administering vasopressors such as phenylephrine increasing inspiratory fraction (FiO2 ). However, whether interventions increase cerebral oxygenation remains...
Hyperlactatemia occurs frequently after brain tumor surgery. Existing studies are scarce and predominantly retrospective, reporting inconsistent associations to new neurological deficits prolonged hospital stay. Here we describe a protocol for prospective observational study of hyperlactatemia during elective craniotomy the association with postoperative outcome, as well selected pathophysiological aspects, possible risk factors. We will include 450 patients scheduled craniotomy. Arterial...
A man in his mid-30s was admitted with a thunderclap headache. He conscious and hypertensive. decade earlier, severe hypertension had been diagnosed extensively investigated without revealing an underlying cause. Brain imaging showed subarachnoid haemorrhage caused by ruptured pericallosal aneurysm. Endovascular occlusion attempted, but as the sheath could not pass aortic arch, it converted to surgical aneurismal clipping. Intraoperative blood pressure measurement revealed peak-to-peak...
Abstract Background The reliability of near‐infrared spectroscopy (NIRS) for measuring cerebral oxygenation (ScO 2 ) is controversial due to the possible contamination from extracranial tissues. We compared ScO measured with NIRS optode on forehead, skull and dura mater in anaesthetised patients undergoing craniotomy. hypothesised that directly would differ skin. Methods This prospective observational study included 17 adult scheduled elective After induction general anaesthesia, was...
Sørensen, M.K.*; Bretlau, C.†; Gätke, M.R.†; A.M.*; Rasmussen, L.S.* Author Information