A5054919591- Renal and related cancers
- Organ Donation and Transplantation
- Tissue Engineering and Regenerative Medicine
- Pediatric Urology and Nephrology Studies
- Renal Transplantation Outcomes and Treatments
- Organ Transplantation Techniques and Outcomes
- Renal Diseases and Glomerulopathies
- Prenatal Screening and Diagnostics
- Nutrition and Health in Aging
- Urological Disorders and Treatments
- Renal cell carcinoma treatment
- Renal and Vascular Pathologies
- Nephrotoxicity and Medicinal Plants
- Dialysis and Renal Disease Management
- Organ and Tissue Transplantation Research
- Pluripotent Stem Cells Research
- Xenotransplantation and immune response
- Reconstructive Surgery and Microvascular Techniques
- Orthopedic Surgery and Rehabilitation
- Ureteral procedures and complications
- Metabolism and Genetic Disorders
- Facial Trauma and Fracture Management
- Central Venous Catheters and Hemodialysis
- Pregnancy and Medication Impact
- Sarcoma Diagnosis and Treatment
Jikei University School of Medicine
1994-2025
The University of Tokyo
1992-2025
Jichi Medical University
2019-2021
Jichi Medical University Hospital
2019-2021
Japanese Red Cross Medical Center
2017-2018
Nagoya University
1988-1989
Takano Hospital
1987
Tokyo Dental College
1977-1979
Crosslinking of membrane-bound immunoglobulins, which are B-cell antigen receptors, causes proliferation and differentiation B cells or the inhibition their growth. The receptor-mediated signaling involves tyrosine phosphorylation cellular proteins. Src-like protein-tyrosine kinase Lyn is expressed preferentially in an intracytoplasmic constituent receptor complex. immunoglobulin M with antibody induced rapid increases activities Lyn-associated phosphatidylinositol 3-kinase. also association...
Abstract Potter sequence consists of various symptoms associated with renal dysplasia. For bilateral agenesis, there is no hope survival. As a novel therapeutic approach for sequence, we develop unique “transplantation fetal kidneys from different species during the stage.” In this study, first validate using allogeneic transplantation. Fetal bladders green fluorescent protein-expressing rats (embryonic day 14.0–16.5) are subcutaneously transplanted into rat fetuses in utero 18.0–18.5)....
Abstract The objective of this study was to identify the prognostic factors and propose a new risk model in metastatic castration-resistant prostate cancer (mCRPC) patients. clinical data were retrospectively obtained for 102 mCRPC patients who received treatment between 2005 2018 at University Tokyo Hospital. We investigated pathological parameters, including prostate-specific antigen (PSA) kinetic profiles under androgen deprivation treatment, identified predictors overall survival (OS)....
Abstract Fetal cell ablation models are crucial for studying congenital diseases, organ regeneration, and xenotransplantation. However, conventional knockout offer limited control over disease severity, while conditional often require fetus-harming inducers. In the present study, we demonstrate that inducible caspase 9 system enables precise targeting of fetal nephron progenitor cells in mice through intrinsic apoptotic pathway. Using a safe, placenta-permeable inducer, this facilitates...
Novel transplantable organs need to be developed address the global organ shortage. Transplantation of embryonic kidney tissue, or metanephros, facilitates glomerular and tubular maturation offers partial functional support. However, adult environments do not permit exponential growth in size, limiting life-supporting functionality replacement effect this approach. Here, we a novel strategy that combines fusion bladders with multiple anastomoses host ureter, enabling significant increase...
Background: Formalin is widely used as a standard fixative in histopathological analysis; however, its high toxicity and strict regulatory restrictions create challenges for the safe transport external evaluation of specimens. In translational research utilizing large animal models, establishing reliable protocol that preserves both tissue structure antigenicity remains essential. Objective: This study aimed to develop validate formalin-fixed renal specimens while maintaining their...
Kidney xenotransplantation has been attracting attention as a treatment option for end-stage renal disease. Fetal porcine kidneys are particularly promising grafts because they can reduce rejection through vascularization from host vessels. We proposing xenogeneic regenerative medicine using fetal injected with human nephron progenitor cells. For clinical application, it is desirable to establish reliable methods the preservation and quality assessment of grafts. evaluated differentiation...
Some cases of cubital tunnel syndrome are caused by anatomical abnormalities such as the epitrochleo-anconeus muscle or snapping and bulkiness medial head triceps brachii muscle. We report a rare cause that has not been reported previously. It was an abnormal insertion into epicondyle. The clinical course operative findings described.
We aimed to identify prognostic factors of cancer-specific survival (CSS) in non-metastatic castration-resistant prostate cancer (M0CRPC) patients. The final analysis this retrospective cohort included 82 patients who were diagnosed as M0CRPC between 1998 and 2018 at the University Tokyo Hospital. CRPC was defined prostate-specific antigen (PSA) progression (increased PSA ≥ 25% 2 ng/mL above nadir or detection a metastatic lesion). median value age time 76 (range 55-94) years 2.84 2.04-22.5)...
Abstract Kidney organoids have shown promise as evaluation tools, but their in vitro maturity remains limited. Transplantation into adult mice has aided maturation; however, lack of urinary tract connection limits long-term viability. Thus, viable generated nephrons not been demonstrated. In this study, we present an approachable method which mouse and rat renal progenitor cells are injected the developing kidneys neonatal mice, resulting generation chimeric integrated with host tracts....
Background. Intragraft microthrombi prevent complete organ perfusion, thereby compromising the viability maintained by preservation solutions or machine perfusion. Herein, we developed and evaluated a hypobaric perfusion method for flushing from kidney grafts with prolonged circulatory arrest in porcine model. Methods. Porcine renal 1-h warm ischemia were flushed heparin-containing perfusate normobaric environment (control group) of −20 to −30 mm Hg (hypobaric 10 min using gravity drip 1-m...
Abstract Potter sequence, characterized by bilateral renal agenesis, oligohydramnios, and consequent pulmonary hypoplasia, presents a significant challenge in the management of affected neonates. Due to their prematurity associated abdominal complications, these infants often fail reach stage where dialysis can be safely initiated sustained, leading an exceedingly high mortality rate. Therefore, there is hopeful anticipation that interventions serving as bridge achieve state performed will...
Fetal organs and organoids are important tools for studying organ development. Recently, porcine have garnered attention as potential xenotransplantation because of their high degree similarity to human organs. However, meet the prompt demand fetal by patients researchers, effective methods producing, retrieving, cryopreserving pig fetuses indispensable. Therefore, in this study, collect kidney extraction, we employed cesarean sections preserve survival fertility mother a method storing...
Acute kidney injury and its central pathology, renal ischemia reperfusion (IRI), have been studied in many animal models. Although IRI has induced pig models ways, simultaneous bilateral or unilateral along with contralateral nephrectomy only provide data on the response to a single time. Moreover, it reported that prolonged time pigs for 120 min more can cause irreversible damage increase mortality.We developed model induces subsequent without threatening lives of by subjecting left right...
Although transplanting two kidneys from a single donor to recipients has some advantages, the right and left are not anatomically identical; thus, surgical procedure considering anatomical features of is needed when them into opposite renal fossae. Based on vast experience, details pig orthotopic kidney transplantation one was reported.
Evidence regarding volume-outcome effects on peritoneal dialysis (PD) catheter implantation is limited. This study aimed to investigate associations between hospital volume (annual caseload of implantation) and perioperative outcomes.Clinical data for patients who underwent PD from 2007 2012 were extracted the Japanese nationwide Diagnosis Procedure Combination database. Hospital was divided into tertiles: low-volume (1 - 6 cases/year), medium-volume (7 13 high-volume (≥ 14 cases/year)....
Objectives To evaluate the relationship between creatinine reduction ratio postoperative days 1 and 2 post‐transplantation clinical outcomes after living donor kidney transplantation. Methods Clinical data of patients who underwent transplantation at Jichi Medical University Hospital, Tochigi, Japan, 2006 2019 were retrieved. The was calculated based on formula: (Cre1 − Cre2) × 100/Cre1; then classified into either slow graft function (creatinine ≤30%) or immediate >30%) group. We carried...
To align the xeno-metanephros and renal progenitor cell timing for transplantation treatments, cryopreservation techniques an efficient transportation of regenerated products such as xeno-metanephroi cells should be established. Therefore, we propose a novel method xenogeneic regenerative medicine patients with chronic kidney disease by grafting porcine fetal kidneys injected human cells. develop useful cryopreserve system cells, examined implanted in mouse model. First, developed new direct...