A5037277824- Epilepsy research and treatment
- Psychosomatic Disorders and Their Treatments
- EEG and Brain-Computer Interfaces
- Suicide and Self-Harm Studies
- Functional Brain Connectivity Studies
- Schizophrenia research and treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Obsessive-Compulsive Spectrum Disorders
- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Dementia and Cognitive Impairment Research
- Pharmacological Effects and Toxicity Studies
- Ion channel regulation and function
- Neuroscience and Neural Engineering
- Genetic Neurodegenerative Diseases
- Neurology and Historical Studies
King's College London
2021-2025
St George’s University Hospitals NHS Foundation Trust
2020-2023
Maastricht University
2018
University of East London
2018
Background and purpose Hypomimia is a prominent clinical feature in people with Parkinson’s disease (PD), but it remains under‐investigated. We aimed to examine the correlates of hypomimia PD determine whether this levodopa‐responsive sign. Methods included 89 PD. was assessed from digital video recordings by movement disorder specialists. Clinical evaluation use Unified Disease Rating Scale part III (UPDRS‐III), assessment motor non‐motor symptoms using standardized scales. The...
BackgroundOnline technology could potentially revolutionise how patients are cognitively assessed and monitored. However, it remains unclear whether assessments conducted remotely can match established pen-and-paper neuropsychological tests in terms of sensitivity specificity.MethodsThis observational study aimed to optimise an online cognitive assessment for use traumatic brain injury (TBI) clinics. The tertiary referral clinic which this tool has been clinically implemented typically sees...
The underrepresentation of acute psychiatric settings in epilepsy research presents a barrier to delivering equitable healthcare for people with comorbid and severe mental illness. We aimed report the prevalence among receiving inpatient care examine sociodemographic clinical characteristics influencing their treatment outcomes. analysed electronic patient records estimate lifetime retrospective cohort 9,237 admitted wards South London between 2015 2019. Hospital national databases were used...
Background People with functional/dissociative seizures (FDS) are at elevated suicidality risk. Objective To identify risk factors for in FDS or epilepsy. Methods Retrospective cohort study from the UK’s largest tertiary mental healthcare provider, linked national admission data Hospital Episode Statistics. Participants were 2383 people a primary secondary diagnosis of epilepsy attending between 01 January 2007 and 18 June 2021. Outcomes first report suicidal ideation hospital suicide...
STRUCTURED ABSTRACT Objective To explore the relationship between cognitive functioning and psychopathological features in Functional/Dissociative Seizures (FDS), test whether this differs from that observed epilepsy. Methods We recruited a cross-sectional sample of adults (age > 18) with diagnosis non-lesional epilepsy or FDS January 2021 July 2022. Participants completed series psychiatric questionnaires neuropsychological measures. Spearman’s Correlation Coefficient was computed each...
Objectives To test the hypothesis that people with concurrent diagnosis of epilepsy and psychogenic nonepileptic seizures (PNES) are at increased risk attempting suicide as compared to or PNES alone. report on rates. Methods Retrospective cohort study from UK largest tertiary mental health care provider, linked nationwide admission mortality data Hospital Episode Statistics Office for National Statistics. Participants were 2460 a primary secondary epilepsy, attending between 1 January 2007...
ABSTRACT Objective To identify risk factors for first episodes of suicidal ideation and suicide attempt in people with functional/dissociative seizures (FDS) or epilepsy. Methods Retrospective cohort study from the UK’s largest tertiary mental health care provider, linked national admission data Hospital Episode Statistics (HES). Participants were 2383 a primary secondary diagnosis FDS epilepsy attending between 01/01/2007 18/06/2021. Outcomes report hospital (ICD-10 X60-X84). Demographic...
Background: Online technology could potentially revolutionise how patients are cognitively assessed and monitored. However, it remains unclear whether assessments conducted remotely can match established pen-and-paper neuropsychological tests in terms of sensitivity or domain specificity.Methods: We applied a novel approach to optimise multi-scale online assessment for use traumatic brain injury (TBI) clinics. First, we cross-group, cross-device factor analyses identify battery tasks that...
Differentiating between epilepsy and psychogenic non-epileptic seizures presents a considerable challenge in clinical practice, resulting frequent misdiagnosis, unnecessary treatment long diagnostic delays. Quantitative markers extracted from resting-state EEG may reveal subtle neurophysiological differences that are diagnostically relevant. Two observational, retrospective accuracy studies were performed to test the validity of univariate for differential diagnosis seizures. Clinical data...