A5057888506- Orthopedic Surgery and Rehabilitation
- Traumatic Brain Injury and Neurovascular Disturbances
- Alzheimer's disease research and treatments
- Autoimmune Bullous Skin Diseases
- Elbow and Forearm Trauma Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Dementia and Cognitive Impairment Research
- Pituitary Gland Disorders and Treatments
- Aortic aneurysm repair treatments
- Shoulder Injury and Treatment
- Traumatic Brain Injury Research
- Bone fractures and treatments
- Embodied and Extended Cognition
- Spinal Fractures and Fixation Techniques
- Intensive Care Unit Cognitive Disorders
- Renal and Vascular Pathologies
- Intramuscular injections and effects
- Platelet Disorders and Treatments
- COVID-19 and healthcare impacts
- Migraine and Headache Studies
- EEG and Brain-Computer Interfaces
- Psychosomatic Disorders and Their Treatments
- Neural and Behavioral Psychology Studies
- Scoliosis diagnosis and treatment
- Cerebrospinal fluid and hydrocephalus
Coventry (United Kingdom)
2024
University Hospitals Coventry and Warwickshire NHS Trust
2024
Imperial College London
2020-2024
King's College London
2022-2024
UK Dementia Research Institute
2020-2024
Hammersmith Hospital
2022-2024
University of Surrey
2022-2024
King's College Hospital
2024
Wellcome Trust
2024
Queen Elizabeth Hospital
2024
"How we learn: the new science of education and brain." Cognitive Neuropsychiatry, 26(1), pp. 73–74
Background Dysfunction of the locus coeruleus-noradrenergic system occurs early in Alzheimer’s disease, contributing to cognitive and neuropsychiatric symptoms some patients. This offers a potential therapeutic target, although noradrenergic treatments are not currently used clinical practice. Objective To assess efficacy drugs with principally action improving disease. Methods The MEDLINE, Embase ClinicalTrials.gov databases were searched from 1980 December 2021. We generated pooled...
In an interview for “Consciousness Live” in 2019 (available here: https://www.youtube.com/watch?v=QsAh-Wl3Eac), Steve Fleming talked about developing his skills as a science communicator—someone wh...
BackgroundOnline technology could potentially revolutionise how patients are cognitively assessed and monitored. However, it remains unclear whether assessments conducted remotely can match established pen-and-paper neuropsychological tests in terms of sensitivity specificity.MethodsThis observational study aimed to optimise an online cognitive assessment for use traumatic brain injury (TBI) clinics. The tertiary referral clinic which this tool has been clinically implemented typically sees...
Abstract An accurate diagnosis of neurodegenerative disease and traumatic brain injury is important for prognostication treatment. Neurofilament light glial fibrillary acidic protein (GFAP) are leading biomarkers neurodegeneration activation that detectable in blood. Yet, current recommendations require rapid centrifugation ultra-low temperature storage post-venepuncture. Here, we investigated if these markers can be accurately measured finger-prick blood using dried plasma spot cards. Fifty...
Internet of Things (IoT) technology enables physiological measurements to be recorded at home from people living with dementia and monitored remotely. However, in this context have not been previously studied. We report on the distribution 82 over approximately 2 years.Our objective was characterize physiology when measured their own homes. also wanted explore possible use an alerts-based system for detecting health deterioration discuss potential applications limitations kind system.We...
Familial pemphigus vulgaris was found in a Jewish woman and her son who developed the disease within period of 18 months from one another. HLA typing performed mother as well unaffected father sister. Examination antigens this family indicates that there may be different variants DR4, DQw3 them carried by part haplotype A30, B18, is associated with vulgaris. Our findings are favor concept particular polymorphic residues class II major histocompatibility molecules correlated susceptibility.
Aims: The demand for elective hand surgery has increased substantially over the last 10 years. With COVID-19 providing an added challenge of restrictions on face-to-face consultations, already overflowing follow-up clinics will be stressed further. Our aim is to assess viability, effectiveness, and safety early discharge directly from operating theatre following common procedures with net open-access follow-up. Methods: All eligible patients undergoing open-hand under local anaesthesia...
Abstract Traumatic brain injury commonly impairs attention and executive function, disrupts the large-scale networks that support these cognitive functions. Abnormalities of functional connectivity are seen in corticostriatal networks, which associated with dysfunction damage to neuromodulatory catecholaminergic systems caused by head injury. Methylphenidate, a stimulant medication increases extracellular dopamine noradrenaline, can improve function following TBI. In this experimental...
Abstract Background Idiopathic normal pressure hydrocephalus (iNPH) is characterised by gait disturbance, urinary incontinence and cognitive impairment. Symptoms are potentially reversible via cerebrospinal fluid (CSF) diversion; thus early accurate diagnosis crucial. imaging features of iNPH often overlap with Alzheimer’s disease (AD) other neurodegenerative conditions, which represent a major diagnostic challenge. We aimed to demonstrate the utility computerised neuropsychology testing aid...