A5048275556- Dementia and Cognitive Impairment Research
- Traumatic Brain Injury and Neurovascular Disturbances
- Traumatic Brain Injury Research
- Health, Environment, Cognitive Aging
- Alzheimer's disease research and treatments
- Cardiac Arrest and Resuscitation
- Intensive Care Unit Cognitive Disorders
- Advanced Neuroimaging Techniques and Applications
- Sleep and related disorders
- Psychosomatic Disorders and Their Treatments
- Anesthesia and Neurotoxicity Research
- Cerebrospinal fluid and hydrocephalus
- Healthcare Decision-Making and Restraints
- Stress Responses and Cortisol
- Palliative Care and End-of-Life Issues
- Ethics in Clinical Research
- Blood Pressure and Hypertension Studies
- Sleep and Work-Related Fatigue
- Health and Well-being Studies
- Long-Term Effects of COVID-19
- Non-Invasive Vital Sign Monitoring
- Neurosurgical Procedures and Complications
- Sleep and Wakefulness Research
- Fetal and Pediatric Neurological Disorders
- Cardiovascular Syncope and Autonomic Disorders
Imperial College London
2021-2025
UK Dementia Research Institute
2021-2025
University of Surrey
2021-2025
Hammersmith Hospital
2023-2025
University College London
2023
Brain (Germany)
2022
<h2>Summary</h2><h3>Background</h3> Preliminary evidence has highlighted a possible association between severe COVID-19 and persistent cognitive deficits. Further research is required to confirm this association, determine whether deficits relate clinical features from the acute phase or mental health status at point of assessment, quantify rate recovery. <h3>Methods</h3> 46 individuals who received critical care for Addenbrooke's hospital 10th March 2020 31st July (16 mechanically...
Background Dysfunction of the locus coeruleus-noradrenergic system occurs early in Alzheimer’s disease, contributing to cognitive and neuropsychiatric symptoms some patients. This offers a potential therapeutic target, although noradrenergic treatments are not currently used clinical practice. Objective To assess efficacy drugs with principally action improving disease. Methods The MEDLINE, Embase ClinicalTrials.gov databases were searched from 1980 December 2021. We generated pooled...
BackgroundOnline technology could potentially revolutionise how patients are cognitively assessed and monitored. However, it remains unclear whether assessments conducted remotely can match established pen-and-paper neuropsychological tests in terms of sensitivity specificity.MethodsThis observational study aimed to optimise an online cognitive assessment for use traumatic brain injury (TBI) clinics. The tertiary referral clinic which this tool has been clinically implemented typically sees...
Abstract BACKGROUND Alzheimer's disease‐related biomarkers detect pathology years before symptoms emerge, when disease‐modifying therapies might be most beneficial. Remote cognitive testing provides a means of assessing early changes. We explored the relationship between neurodegenerative and cognition in cognitively normal individuals. METHODS remotely deployed 13 computerized Cognitron tasks 255 Insight 46 participants. generated amyloid load positivity, white matter hyperintensity volume...
Internet of Things (IoT) technology enables physiological measurements to be recorded at home from people living with dementia and monitored remotely. However, in this context have not been previously studied. We report on the distribution 82 over approximately 2 years.Our objective was characterize physiology when measured their own homes. also wanted explore possible use an alerts-based system for detecting health deterioration discuss potential applications limitations kind system.We...
Survivors of moderate-to-severe traumatic brain injury (msTBI) frequently experience troublesome unexplained somatic symptoms. Autonomic dysfunction may contribute to these However, there is no previous study clinical subjective and objective autonomic in msTBI.We present results from two groups patients with msTBI. The first, a case-control comparative study, comprises prospectively recruited msTBI outpatients, whom we measured burden symptoms using the Composite Symptom Score (COMPASS31)...
ABSTRACT INTRODUCTION Online assessments are scalable and cost-effective for detecting cognitive changes, especially in elderly cohorts with limited mobility higher vulnerability to neurological conditions. However, determining the uptake, adherence, usability of these older adults, who may have less experience mobile devices is crucial. METHODS 1,776 members (aged 77) MRC National Survey Health Development (NSHD) were invited complete 13 online tasks. Adherence was measured through task...
Abstract Background Idiopathic normal pressure hydrocephalus (iNPH) is characterised by gait disturbance, urinary incontinence and cognitive impairment. Symptoms are potentially reversible via cerebrospinal fluid (CSF) diversion; thus early accurate diagnosis crucial. imaging features of iNPH often overlap with Alzheimer’s disease (AD) other neurodegenerative conditions, which represent a major diagnostic challenge. We aimed to demonstrate the utility computerised neuropsychology testing aid...
Background Dysfunction of the locus coeruleus-noradrenergic system occurs early in Alzheimer’s disease. This results a low-noradrenergic state some patients, which contributes to cognitive and neuropsychi- atric symptoms. We aimed assess efficacy noradrenergic drugs for improving these Methods The MEDLINE, Embase, ClinicalTrials.gov databases were searched from 1980 December 2021. generated pooled estimates using random effects meta-analyses. Results 19 randomised controlled trials, six...
Dementia represents a potentially overwhelming health burden, both for the UK and worldwide. Addressing this fast-growing issue is key priority government, service public. Advances in care including development of efficacious disease-modifying, eventually curative, treatments can only be achieved through effective dementia research. Specifically, research directly involving participants with essential to further understanding. However, working cognitively impaired without capacity consent...
Identifying disease-specific imaging features of idiopathic Normal Pressure Hydrocephalus (iNPH) is crucial to develop accurate diagnoses, although the abnormal brain anatomy patients with iNPH creates challenges in neuroimaging analysis. We quantified cortical thickness and volume using FreeSurfer 7.3.2 19 iNPH, 28 Alzheimer's disease (AD), 30 healthy controls (HC). noted frequent need for manual correction automated segmentation examined effect on results. identified statistically...
<title>Abstract</title> Disturbed sleep is common in ageing and dementia, but objectively quantifying it over time challenging. We validated a contactless under-mattress pressure sensor developed data analysis method to assess patterns the home long periods. Data from 13,588 individuals (3.7 million nights) general population were compared dementia cohort of 93 patients (>40,000 nights). Dementia was associated with heterogeneous disturbances primarily characterised by advanced delayed...
BACKGROUND: Alzheimer's disease-related biomarkers detect pathology years before symptoms emerge, when disease-modifying therapies might be most beneficial. Remote cognitive testing provides a means of assessing early changes. We explored the relationship between neurodegenerative and cognition in cognitively normal individuals. METHODS: remotely deployed 13 computerised Cognitron tasks 255 members Insight 46 study. generated whole brain, hippocampal white matter hyperintensity volumes at...
Abstract Background Dementia‐related biomarkers can detect pathology years before clinical diagnostic criteria are met. Understanding the relationship between and early cognitive changes is crucial as disease‐modifying therapies may have maximum benefits when delivered early. We aimed to demonstrate utility of remote computerised tests in a large cohort cognitively normal older individuals, comparing these standard in‐person assessments investigating their associations with biomarkers....
Abstract Background Cognitive assessments are essential for detecting and monitoring cognitive changes in neurological populations. Compared to standard pen‐and‐paper tests, online tasks offer a more accessible, scalable, repeatable cost‐effective approach assessment. Cognitron is an assessment platform with previously demonstrated validity reliability (1). This study aims derive meaningful insights into the application of computerized older age cohorts by examine usability MRC National...
Abstract Background Growing evidence suggests sleep disturbance may promote Alzheimer’s disease (AD) pathology. However, the relationship between and AD progression remains poorly defined due to lack of longitudinal monitoring methods. We previously presented a novel approach for contactless in people living with dementia (PLWD) 1 . Here, we examine association Dementia Research Institute Sleep Index (DRI‐SI) ‐ an interpretable measure disturbances derived from sensor data clinical...
Abstract Background The hippocampus is a key site of atrophy in Alzheimer’s disease (AD) and MRI derived estimates hippocampal volume have been shown to be robust biomarker AD‐related neurodegeneration. However, its application at the individual level limited by lack reference standards from large normative datasets that can applied across wide range settings. We aimed investigate utility centile scores adjusted for age, sex total intracranial (TIV) data 101,457 participants life course, as...
Abstract Introduction Many commonly prescribed medications have inadvertent anticholinergic effects. People with Dementia (PwD) are more vulnerable to these effects and at risk of adverse outcomes, the being higher a greater degree exposure. We investigated prescribing patterns Anticholinergic burden (ACB) in cohort community-dwelling older adults dementia aimed explore effect ACB on cognition, mood, quality life(QoL). Method The medication demographic information for 87 (39 female) PwD were...
Background: Online technology could potentially revolutionise how patients are cognitively assessed and monitored. However, it remains unclear whether assessments conducted remotely can match established pen-and-paper neuropsychological tests in terms of sensitivity or domain specificity.Methods: We applied a novel approach to optimise multi-scale online assessment for use traumatic brain injury (TBI) clinics. First, we cross-group, cross-device factor analyses identify battery tasks that...
Abstract Background Identifying age‐inappropriate cortical neurodegeneration on structural MRI is a key component of Alzheimer’s disease (AD) assessment. However, widely available reference standards that enable objective interpretation are lacking. BrainChart (www.BrainChart.io; https://github.com/BrainChart/Lifespan) calculates age and sex adjusted centile scores for metrics using normative data from 101,457 participants across the lifecourse can be applied different datasets. We this...
Abstract Background Identifying age‐inappropriate cortical neurodegeneration on structural MRI is a key component of Alzheimer’s disease (AD) assessment. However, widely available reference standards that enable objective interpretation are lacking. BrainChart (www.BrainChart.io; https://github.com/BrainChart/Lifespan) calculates age and sex adjusted centile scores for metrics using normative data from 101,457 participants across the lifecourse can be applied different datasets. We this...
Background Survivors of moderate-severe traumatic brain injury (msTBI) frequently experience trouble- some unexplained somatic symptoms, which may be attributable to autonomic dysfunction. Methods We conducted two cohort studies. Cohort 1 comprises msTBI patients (with controls) prospec- tively recruited from a regional referral TBI outpatient clinic, in whom we assessed subjective burden symptoms using the Composite Autonomic Symptom Score (COMPASS31) questionnaire. 2 who had clinical...
Abstract Background and Objective Survivors of moderate-severe traumatic brain injury (msTBI) frequently experience chronic, debilitating somatic symptoms, which are largely unexplained. The phenomenon paroxysmal sympathetic hyperactivity, reflecting hyperacute autonomic dysfunction, is well-documented after msTBI. Limited animal human studies, using experimental measures, have found evidence for dysfunction However, no studies investigated the range type symptoms existing in We set out to...