A5085705068- Spine and Intervertebral Disc Pathology
- Musculoskeletal pain and rehabilitation
- Health, Environment, Cognitive Aging
- Pregnancy-related medical research
- Nutrition and Health in Aging
- Dementia and Cognitive Impairment Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Rheumatoid Arthritis Research and Therapies
- Osteoarthritis Treatment and Mechanisms
- Connective tissue disorders research
- Spondyloarthritis Studies and Treatments
- Health, psychology, and well-being
- Wikis in Education and Collaboration
- Healthcare and Venom Research
- Pain Mechanisms and Treatments
- Nutrition, Genetics, and Disease
- Chronic Disease Management Strategies
- Cardiovascular and exercise physiology
- Systemic Lupus Erythematosus Research
- Health disparities and outcomes
- Medical Imaging and Analysis
- Cytokine Signaling Pathways and Interactions
- Alzheimer's disease research and treatments
- Hip and Femur Fractures
- Birth, Development, and Health
University College London
2016-2025
MRC Unit for Lifelong Health and Ageing
2016-2025
King's College London
2010-2012
Objective Low back pain (LBP) is a common musculoskeletal disorder, but it still unclear which individuals develop it. The authors examined the contribution of genetic factors, lumbar disc degeneration (LDD) and other risk factors in female sample general population. Material Methods A cross-sectional study was conducted among 2256 women (371 698 monozygotic dizygotic twin pairs 29 sibling 60 singletons) with mean age 50 years (18–84). self-reported validated questionnaire used to collect...
Cross-sectional open population based study (nested in a prospective cohort study).To explore the association of different individual radiographic features, including osteophytes and disc space narrowing, with self-reported low back pain (LBP). Different definitions lumbar degeneration LBP disability were considered large sample. Furthermore, order to disentangle discrepancies reported strength associations, we characterized frequency features degeneration, as well their status, by age,...
A life course approach to ageing relies on maintaining participation rates in national birth cohorts and other long-term longitudinal studies. This reduces the risk of selective attrition biasing associations between lifetime factors health outcomes later ensures studies remain as representative possible original population. We report patterns for a postal questionnaire home visit at 68–69 years study members MRC National Survey Health Development, oldest longest-running British cohort...
Obesity and chronic low-grade inflammation have both been implicated in the onset of physical fatigue. However, few studies investigated independence these associations older community-dwelling populations. We therefore aimed to investigate body mass index (BMI) inflammatory markers at age 60–64 with perceived fatigability 68 assess whether any such were independent each other potential confounding factors. A secondary aim was association BMI extended back into earlier adulthood....
Objective Osteoarthritis (OA) and osteoporosis are often considered to lie at opposite ends of a spectrum bone phenotypes. Lumbar degenerative disc disease (LDD) may be associated with low back pain (LBP) is similar in many ways OA. LDD reported small studies increased spine mineral density (BMD). The present work aimed confirm this association large population sample using MRI explore the relationship further, particular determine whether it mediated genetically. Methods A based (N=908, age...
<h3>Objectives</h3> Lumbar disc degeneration (LDD) is prevalent, age-related and contributes to low back pain. Cross-sectional LDD as determined by MRI scan known be highly heritable. The authors postulated that the rate of progression might also controlled genetic factors. <h3>Methods</h3> A 10-year follow-up MRI-determined was performed in 234 pairs twin volunteers UK Australia, comprising 90 monozygotic 144 dizygotic same-sex pairs. Of total sample, 95% were female. mean age at baseline...
Abstract BACKGROUND Alzheimer's disease‐related biomarkers detect pathology years before symptoms emerge, when disease‐modifying therapies might be most beneficial. Remote cognitive testing provides a means of assessing early changes. We explored the relationship between neurodegenerative and cognition in cognitively normal individuals. METHODS remotely deployed 13 computerized Cognitron tasks 255 Insight 46 participants. generated amyloid load positivity, white matter hyperintensity volume...
Background Blood pressure, grip strength and lung function are frequently assessed in longitudinal population studies, but the measurement devices used differ between studies within over time. We aimed to compare measurements ascertained from different commonly devices. Methods a randomised cross-over study. Participants were 118 men women aged 45–74 years whose blood using two sphygmomanometers (Omron 705-CP Omron HEM-907), four handheld dynamometers (Jamar Hydraulic, Jamar Plus+ Digital,...
ABSTRACT INTRODUCTION Online assessments are scalable and cost-effective for detecting cognitive changes, especially in elderly cohorts with limited mobility higher vulnerability to neurological conditions. However, determining the uptake, adherence, usability of these older adults, who may have less experience mobile devices is crucial. METHODS 1,776 members (aged 77) MRC National Survey Health Development (NSHD) were invited complete 13 online tasks. Adherence was measured through task...
Background & IntroductionThe Medical Research Council National Survey of Health and Development (NSHD) is the oldest longest-running British birth cohort studies. In 2018 we launched Skylark Wiki, a central metadata repository first port call for any data sharing queries. 2023 utilised HDRUK funding initiative to work with our advisory group research community improve transparency access process make content more accessible. MethodsWe conducted focus session NSHD Participant Advisory...
BACKGROUND: Alzheimer's disease-related biomarkers detect pathology years before symptoms emerge, when disease-modifying therapies might be most beneficial. Remote cognitive testing provides a means of assessing early changes. We explored the relationship between neurodegenerative and cognition in cognitively normal individuals. METHODS: remotely deployed 13 computerised Cognitron tasks 255 members Insight 46 study. generated whole brain, hippocampal white matter hyperintensity volumes at...
Abstract Background Dementia‐related biomarkers can detect pathology years before clinical diagnostic criteria are met. Understanding the relationship between and early cognitive changes is crucial as disease‐modifying therapies may have maximum benefits when delivered early. We aimed to demonstrate utility of remote computerised tests in a large cohort cognitively normal older individuals, comparing these standard in‐person assessments investigating their associations with biomarkers....
Abstract Background Cognitive assessments are essential for detecting and monitoring cognitive changes in neurological populations. Compared to standard pen‐and‐paper tests, online tasks offer a more accessible, scalable, repeatable cost‐effective approach assessment. Cognitron is an assessment platform with previously demonstrated validity reliability (1). This study aims derive meaningful insights into the application of computerized older age cohorts by examine usability MRC National...
While there is an acknowledged need for biomarkers to progress arthritis research, imaging the spine have lagged behind those peripheral joint osteoarthritis. Progress has been slow a number of reasons. First and perhaps most importantly, currently no international agreement on definition osteoarthritis (OA), either histologically or imaging. Secondly, OA comprises two main pathologies, debate continues as whether they are separate entities linked: degenerative disc disease facet arthritis....
Physical fatigability, the level of fatigue experienced while undertaking specified physical tasks, increases with age. These age-related changes, which reflect reductions in energy availability, precipitate declines function and activity participation. Cross-sectional analyses suggest that obesity inflammation may be modifiable risk factors for fatigability require further investigation longitudinal studies. Using data on 2095 participants from MRC National Survey Health Development, a...
<h3>Background</h3> Physical fatigability, the level of fatigue experienced while undertaking specified physical tasks, increases with age throughout adulthood. These age-related changes, which reflect reductions in energy availability, precipitate declines activity participation and function. Higher levels are also related to increased risk disability premature mortality so it is imperative identify modifiable factors across life associated fatigability. Cross-sectional analyses suggest...