A5067064957- Psychedelics and Drug Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Memory and Neural Mechanisms
- Neural dynamics and brain function
- Chemical synthesis and alkaloids
- Injury Epidemiology and Prevention
- Neuroscience and Neuropharmacology Research
- Traumatic Brain Injury Research
- Traffic and Road Safety
- Misinformation and Its Impacts
- Dementia and Cognitive Impairment Research
- Complementary and Alternative Medicine Studies
- Risk Perception and Management
- Paranormal Experiences and Beliefs
- Pain Management and Placebo Effect
- Cardiomyopathy and Myosin Studies
- Advanced Neuroimaging Techniques and Applications
- Cannabis and Cannabinoid Research
- Multiple Sclerosis Research Studies
- Neurobiology of Language and Bilingualism
- Boron Compounds in Chemistry
- Noise Effects and Management
- Hate Speech and Cyberbullying Detection
- Parkinson's Disease Mechanisms and Treatments
- Trace Elements in Health
Imperial College London
2017-2025
King's College London
2025
Hammersmith Hospital
2023
Wellcome Centre for Human Neuroimaging
2020-2021
University of Birmingham
2017-2020
Psychedelic microdosing describes the ingestion of near-threshold perceptible doses classic psychedelic substances. Anecdotal reports and observational studies suggest that may promote positive mood well-being, but recent placebo-controlled failed to find compelling evidence for this. The present study collected web-based mental health related data using a prospective (before, during after) design. Individuals planning weekly regimen completed surveys at strategic timepoints, spanning core...
Abstract Poor outcomes after traumatic brain injury (TBI) are common yet remain difficult to predict. Diffuse axonal is important for outcomes, but its assessment remains limited in the clinical setting. Currently, diagnosed based on presentation, visible damage white matter or via surrogate markers of such as microbleeds. These do not accurately quantify leading misdiagnosis a proportion patients. Diffusion tensor imaging provides quantitative measure vivo, with fractional anisotropy often...
Abstract Automated online cognitive assessments are set to revolutionise clinical research and healthcare. However, their applicability for Parkinson’s Disease (PD) REM Sleep Behavioural Disorder (RBD), a strong PD precursor, is underexplored. Here, we developed an battery measure early changes in RBD. Evaluating 19 candidate tasks showed significant global accuracy deficits (0.65 SD, p = 0.003) RBD (0.45 0.027), driven by memory, language, attention executive underperformance, reaction time...
BackgroundOnline technology could potentially revolutionise how patients are cognitively assessed and monitored. However, it remains unclear whether assessments conducted remotely can match established pen-and-paper neuropsychological tests in terms of sensitivity specificity.MethodsThis observational study aimed to optimise an online cognitive assessment for use traumatic brain injury (TBI) clinics. The tertiary referral clinic which this tool has been clinically implemented typically sees...
Abstract This commentary explores public priorities in psychedelic research, drawing insights from extensive conversations between the author and general during lectures seminars across UK. Two primary themes emerged this exchange: areas where further research is desired concerns about current direction of research. Key topics interest include psychedelics' effects on neurodivergent individuals, ageing, pain management, cognitive enhancement, psychosis, interactions with female menstrual...
Background Metacognition is the ability to monitor and self-assess cognitive performance. It can be impaired in neurodegenerative diseases, with implications for daily function, of patients reliably report their symptoms health professionals. However, metacognition has not been systematically assessed early-mid stage Parkinson’s disease (PD) REM sleep behavioral disorder (RBD), a prodrome PD. Objectives This study aimed evaluate metacognitive accuracy self-confidence PD RBD across various...
The large-scale disruption to peoples' daily lives during the COVID-19 pandemic provides a context for examining whether use of substances such as psychedelics in naturalistic (outside controlled environment) setting, is associated with better mental wellbeing and resilience relative those who other drugs, or do not drugs at all. We interrogate data from Great British Intelligence Test identify that 7.8% out
The current study was conducted on a sample of 91 patients diagnosed with diastolic dysfunction (DD) preserved systolic function caused by painful chronic ischaemic cardiopathy – angina pectoris stable at the effort. diagnosis established following anamnesis, electrocardiogram, and echocardiography. Myeloperoxidase (MPO) serum levels were assessed in all then these values correlated some echocardiography parameters that proved mentioned diagnosis.In conclusion, execution this investigation...
Abstract Two experiments aimed to determine whether working memory capacity (WMC) and high‐order executive functions predict drown detection performance maintenance under heightened task demands. Experiment 1 ( n = 111) found a positive correlation between enhanced scores higher WMC, while function showed no comparable association. 2 28) individuals with elevated WMC demonstrated an ability detect greater number of drowning events over extended period overall, relative their lower scoring...
The gamma-glutamyltransferase (GGT) is recognized in medical practice as a useful indicator for the detection of liver lesions, especially those induced by excessive consumption alcoholic or cholesterol-associated drinks. present study, although it includes very small number cases diagnosed with colon diverticulosis-diverticulitis associated polyposis at same intestinal level, identifies presence increased circulating concentrations this enzyme serum. Its serum levels are tracked...
For the medical practice, our manuscript acts as a signal, despite only presenting three cases which feature association between hepatocytolysis, haemolysis and hypermagnesaemia. This clinical-biologic triad was highlighted with workers who through nature of their profession were exposing themselves periodically to vapours contained copper sulphate neutralised calcium hydroxide, fungicide used for fruit trees. We are exclusively assessing haematological perturbation. In this aetiological...
Abstract This commentary addresses the potential for a nocebo effect arising from public discourse on psychedelics, especially considering increasing interest and engagement with these substances. The resurgence of psychedelics in scientific arenas has led to proliferation discussions, both positive cautionary, about their use. However, an imbalance this discourse, particularly focus harms without adequate contextualisation, might inadvertently create effect. could manifest naturalistic...
This case report examines the profound experience of spontaneous, unmedicated labour in a home setting. The 28-year-old woman, with prior history emergency caesarean section due to failed induction labour, underwent natural and birth that elicited an altered state consciousness. During she experienced significant euphoria, unique perceptual alteration her environment, alongside sense connection body. account provides crucial insights into psychological (and even spiritual) dimensions...
Psychoactive drugs are agents with significant potential, intriguing in their complexity and powerful effects. However, the moral valence often attributed to these effects – whether positive or negative is not an intrinsic property of themselves. Instead, it by humans, for whom shaped surrounding context, including socio-cultural factors, specific circumstances, intentions those administering experimenting them. The present study uses natural language processing perform sentiment mining...
Abstract The COVID-19 pandemic represents a unique context for studying the spread of conspiratorial beliefs within general population and their role in mediating compliance with government guidance. Here, we apply multivariate machine learning methods to analyse data from tens thousands members British public at 6-monthly timepoints during pandemic. We report that distrust significantly predict non-compliant behaviours covary sociodemographic variables, being most prevalent disadvantaged...
Which population factors have predisposed people to disregard government safety guidelines during the COVID-19 pandemic and what justifications do they give for this non-compliance? To address these questions, we analyse fixed-choice free-text responses survey questions about compliance handling of pandemic, collected from tens thousands members UK public at three 6-monthly timepoints. We report that sceptical opinions mainstream-media narrative, especially as pertaining justification...
Background: Online technology could potentially revolutionise how patients are cognitively assessed and monitored. However, it remains unclear whether assessments conducted remotely can match established pen-and-paper neuropsychological tests in terms of sensitivity or domain specificity.Methods: We applied a novel approach to optimise multi-scale online assessment for use traumatic brain injury (TBI) clinics. First, we cross-group, cross-device factor analyses identify battery tasks that...
Traumatic brain injury (TBI) is a complex and heterogeneous disorder. Potentially preventable ‘secondary injury’ develops after trauma believed to underlie the functional impairments seen in TBI patients. Current treatment mainly supportive no specific neuroprotective drugs are available. Over-activation of N-methyl-d-aspartate (NMDA) receptors thought play crucial role secondary development. Xenon, general anaesthetic competitive inhibitor at glycine site NMDA receptor,1 models ischaemia....
Abstract Studies of memory reconsolidation pavlovian memories have typically employed unimodal conditioned stimuli, despite the use multimodal compound stimuli in other settings. Here we studied sign-tracking behaviour to a audiovisual stimulus. First, observed not unexpectedly that was poorer than visual stimuli. Then, showed that, depending on parameters stimulus re-exposure at reactivation, systemic MK-801 treatment either impaired extinction improve signtracking test, or disrupted impair...