A5040388388- Metabolism and Genetic Disorders
- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Biochemical Acid Research Studies
- Peroxisome Proliferator-Activated Receptors
- Mitochondrial Function and Pathology
- Essential Oils and Antimicrobial Activity
- Selenium in Biological Systems
- Phytochemicals and Antioxidant Activities
- Pesticide Exposure and Toxicity
- Sirtuins and Resveratrol in Medicine
- GDF15 and Related Biomarkers
- Alcoholism and Thiamine Deficiency
- Ovarian function and disorders
- Molecular Biology Techniques and Applications
- Hedgehog Signaling Pathway Studies
- Tannin, Tannase and Anticancer Activities
- Reproductive Health and Technologies
- Nanoparticles: synthesis and applications
- Sexual Differentiation and Disorders
- Sarcoma Diagnosis and Treatment
- Biochemical and biochemical processes
- Prenatal Screening and Diagnostics
- Biochemical and Molecular Research
- Seaweed-derived Bioactive Compounds
University of Siena
2014-2025
Istituto per il Sistema Produzione Animale in Ambiente Mediterraneo
2008
National Research Council
2008
Currently, many environmental and energy-related problems are threatening the future of our planet. In October 2022, Worldmeter recorded world population as 7.9 billion people, estimating that there will be an increase 2 by 2057. The rapid growth continuous in needs causing worrying conditions, such pollution, climate change, global warming, waste disposal, natural resource reduction. Looking for novel innovative methods to overcome these troubles is a must common welfare. circular...
The “circular bioeconomy” offers numerous opportunities for the health, cosmetic, and nutrition sectors through potential reuse of Castanea sativa by-products. This abundant sustainable resource provides valuable bioactive secondary metabolites with antioxidants anti-inflammatory properties. transformation these by-products into high-value products human health can contribute to economic growth reduce environmental impact traditional waste disposal practices, thus creating added value from...
Utilizing plant-based resources, particularly their by-products, aligns with sustainability principles and circular bioeconomy, contributing to environmental preservation. The therapeutic potential of plant extracts is garnering increasing interest, this study aimed demonstrate promising outcomes from an extract obtained underutilized waste. Chaetomorpha linum, invasive macroalga found in the Orbetello Lagoon, thrives eutrophic conditions, forming persistent mats covering approximately 400...
Repurposing saffron (
This retrospective study was aimed at evaluating the effects of cigarette consumption on semen parameters in a group men with idiopathic infertility. The quality 2 groups infertility, smokers (n = 118) and nonsmokers 153), were compared. Conventional analysis performed sperm morphology assessed by transmission electron microscopy (TEM). TEM data elaborated means mathematical formula based Bayesian technique able to furnish fertility index (FI), percentages apoptosis, necrosis, immaturity....
Background . Alkaptonuria, a rare autosomal recessive metabolic disorder caused by deficiency in homogentisate 1,2-dioxygenase activity, leads to accumulation of oxidised homogentisic acid cartilage and collagenous structures present all organs tissues, especially joints heart, causing pigmentation called ochronosis. A secondary amyloidosis is associated with AKU. Here we report study an aortic valve from AKU patient. Results Congo Red birefringence, Th-T fluorescence, biochemical assays...
Currently, one-third of global food production, accounting for 1.3 billions tons, goes wasted due to major humanitarian and environmental challenges. In such a scenario, the circular bioeconomy model stands as an innovative solution by promoting sustainable utilizing agri-food waste, converting non-renewable products into valuable resources. Here, concept was applied on previously obtained chestnut burr extract (agri-food waste) composed gallic acid, quinic protocatechuic brevifolin...
The sustainable utilization of biomass-derived bioactives addresses the growing demand for natural health products and supports development goals by reducing reliance on synthetic chemicals in healthcare. Cannabis sativa biomass, particular, has emerged as a valuable resource within this context. This study focuses hydroethanolic extract C. leaves (CSE), which exhibited significant levels phenolic compounds contributing to robust antioxidant activity. Evaluation using potassium ferricyanide,...
Green chemistry principles are pivotal in driving sustainable and innovative solutions to global health challenges. This study explores a hydroalcoholic extract from Castanea sativa (chestnut) burrs, an underutilized natural resource, as potent source of antimicrobial compounds against Helicobacter pylori (H. pylori). The demonstrated significant bactericidal activity, synergizing effectively with clarithromycin showing additive effects metronidazole. Remarkably, combining the sub-inhibitory...
Human activities have greatly raised global temperatures by producing greenhouse gases such as carbon dioxide, methane, and nitrous oxide, posing several environmental issues. Addressing these difficulties, we propose a scalable methodology for increasing CO2 absorption reforestation on privately owned agricultural land. This strategy focuses planting commercially valuable high carbon-sequestering trees, mulberry, fig, olive, linden, almond, hemp, one-hectare area. The design features ten...
Alkaptonuria (AKU) is an ultra-rare genetic disorder caused by mutations in the homogentisate 1,2-dioxygenase (HGD) gene, leading to accumulation of homogentisic acid (HGA). Current treatment options are limited, with Nitisinone (Orfadin or NTBC) being only approved drug. However, its long-term use raises concerns due significant adverse effects, highlighting urgent need for safer alternatives. AKU manifests progressive and often painful symptoms, severely impacting patients’ quality life....
Objective. Alkaptonuria (AKU) is an ultra-rare autosomal recessive disease that currently lacks appropriate therapy. Recently we provided experimental evidence AKU a secondary serum amyloid A (SAA)-based amyloidosis. The aim of the present work was to evaluate use antioxidants inhibit SAA and pro-inflammatory cytokine release in AKU. Methods. We adopted human chondrocytic cell model anti-amyloid capacity set had previously been shown counteract ochronosis model. Amyloid presence evaluated by...
Alkaptonuria (AKU) is an ultra-rare genetic disease, in which the accumulation of a toxic metabolite, homogentisic acid (HGA) leads to systemic development ochronotic aggregates. These aggregates cause severe complications mainly at level joints with extensive degradation articular cartilage. Primary cilia have been demonstrated play essential role and maintenance cartilage homeostasis, through their involvement mechanosignaling Hedgehog signaling pathways. has be activated osteoarthritis...
The enzyme 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) is involved in the catabolism of amino acid tyrosine organisms such as bacteria, plants, and animals. It catalyzes conversion to a homogenisate presence molecular oxygen Fe(II) cofactor. This represents key step biosynthesis important compounds, its activity deficiency leads severe, rare autosomal recessive disorders, like tyrosinemia type III hawkinsinuria, for which no cure currently available. 4-HPPD C-terminal tail plays crucial...
Alkaptonuria (AKU) is a rare autosomal recessive metabolic disorder caused by mutations in the homogentisate 1,2-dioxygenase (HGD) gene, leading to accumulation of homogentisic acid (HGA), causing severe inflammatory conditions. Recently, presence serum amyloid A (SAA) has been reported AKU tissues, classifying as novel secondary amyloidosis; AA amyloidosis characterized extracellular tissue deposition fibrils composed fragments SAA. may complicate several chronic conditions, like rheumatoid...
Osteosarcoma (OS) is a highly malignant bone tumour, affecting mainly children and young adults between 10 20 years of age. It represents the most frequent primitive tumour skeletal system characterized by an extremely aggressive clinical course, with rapid development lung metastases. In last few years, targeting Src in treatment OS has become one major challenges new drugs, since elevated kinase activity been associated maintenance phenotype. Recently, SI-83, novel...
Abstract Alkaptonuria (AKU) is a rare multisystem metabolic disease caused by deficient activity of homogentisate 1,2‐dioxygenase (HGD), which leads to the accumulation homogentisic acid (HGA). Currently, there no treatment for AKU. The sole drug with some beneficial effects herbicide nitisinone ( 1 ), an inhibitor p ‐hydroxyphenylpyruvate dioxygenase (4‐HPPD). has been used as life‐saving in infants type I tyrosinemia despite severe side due buildup tyrosine. Four clinical trials treat AKU...