A5017204113- Retinopathy of Prematurity Studies
- Neonatal and fetal brain pathology
- Neonatal Respiratory Health Research
- Retinal Diseases and Treatments
- Pregnancy and preeclampsia studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Child Nutrition and Water Access
- Congenital Diaphragmatic Hernia Studies
- Iron Metabolism and Disorders
- Cardiovascular Conditions and Treatments
- Anesthesia and Neurotoxicity Research
- Optical Imaging and Spectroscopy Techniques
- Ophthalmology and Visual Health Research
- Neonatal Health and Biochemistry
- Immune Response and Inflammation
- Retinal Development and Disorders
- Infant Nutrition and Health
- Racial and Ethnic Identity Research
- Patient-Provider Communication in Healthcare
- Breastfeeding Practices and Influences
- Respiratory Support and Mechanisms
- Healthcare Systems and Reforms
- Global Health and Epidemiology
- Family and Patient Care in Intensive Care Units
- Blood Coagulation and Thrombosis Mechanisms
University of Wisconsin–Madison
2014-2022
University of Rochester
2022
Highland Community College - Illinois
2015
University of Illinois Chicago
2012-2013
Comer Children's Hospital
2013
ObjectiveTo investigate recombinant human insulin-like growth factor 1 complexed with its binding protein (rhIGF-1/rhIGFBP-3) for the prevention of retinopathy prematurity (ROP) and other complications among extremely preterm infants.Study designThis phase 2 trial was conducted from September 2014 to March 2016. Infants born at a gestational age 230/7 weeks 276/7 were randomly allocated rhIGF-1/rhIGFBP-3 (250 µg/kg/ 24 hours, continuous intravenous infusion <24 hours birth postmenstrual...
ABSTRACT Purpose Retinopathy of prematurity (ROP) is a potentially blinding vasoproliferative disease. There no standardized way to quantify plus disease (tortuous and dilated retinal vessels) or characterize abnormal recovery during ROP monitoring. This study objectively studies vascular features in live mice development using noninvasive imaging. Methods Using fluorescein angiography (FA), were quantified with oxygen induced retinopathy (OIR). A total 105 wild-type exposed 77% from...
Purpose.: Oxygenation abnormalities are implicated in the development of retinopathy prematurity (ROP). The purpose this study is to report vivo retinal vascular oxygen tension (PO2) measurements and fluorescein angiography (FA) findings mouse model oxygen-induced (OIR). Methods.: We exposed 19 neonatal mice 77% from postnatal day 7 (P7) P12 (OIR), while 11 were kept under room air (control). Using phosphorescence lifetime imaging, PO2 was measured followed by FA. Repeated measures ANOVA...
Purpose: Retinopathy of prematurity (ROP) is a condition abnormal retinal vascularization with reduced levels vascular endothelial growth factor (VEGF) causing vaso-obliteration (Phase I), followed by neovascularization from increased VEGF II). We hypothesized that intravitreal pro-angiogenic VEGF-A in microparticle form would promote earlier revascularization an oxygen-induced ischemic retinopathy (OIR) mouse model.Materials and Methods: Wildtype mice (39) were exposed to 77% oxygen...
Retinopathy of prematurity (ROP) is a condition abnormal retinal vascular development (RVD) in premature infants. Fluorescein angiography (FA) has depicted phases (early, mid, late, and mature) RVD oxygen-induced retinopathy (OIR) mice. We sought to establish the relationship between structural changes using simultaneous FA spectral domain optical coherence tomography (SD-OCT). 63 mice were exposed 77% oxygen at postnatal day 7 (P7) for 5 days, while remained room air (RA). Total thickness...
Introduction . Child mortality rate in sub-Saharan Africa is 29 times higher than that industrialized countries. Anemia one of the preventable causes child morbidity. During a humanitarian medical mission rural South-Eastern Nigeria, prevalence and risk factors anemia were determined region order to identify strategies for reduction. Methods A cross-sectional study was done on 96 children aged 1-7 years from 50 randomly selected families. questionnaire used collect information regarding...
<strong>Objectives:</strong> Iron-deficiency anemia (IDA) is a global cause of morbidity in children under five, particularly sub-Saharan Africa. In southeast Nigeria, poor dietary intake and caregiver knowledge about childhood are observed; however, there no consensus on how to best prevent it. This study seeks test the effectiveness education improving prevention strategies promoting sustainable lifestyle changes reduce prevalence IDA. <strong>Study Design: </strong>A questionnaire was...
Abstract Background Pathologic ocular neovascularization in retinopathy of prematurity (ROP) and other proliferative retinopathies are characterized by dysregulation vascular endothelial growth factor-A (VEGF-A). A study Vegfa isoform expression during oxygen-induced ischemic (OIR) may enhance our understanding Vegf dysregulation. Methods Following induction OIR, immunohistochemistry polymerase chain reaction (PCR) was performed on room air (RA) OIR mice. Results Total messenger RNA (mRNA)...
In both fetal and neonatal physiologic pathologic processes in most organs, endothelial cells are known to play critical roles. Although the endothelium is one of ubiquitous cell type body, tight adherence blood vessel wall has made it difficult study their diverse function structure. this article, we have reviewed origins explored heterogeneity terms structure, function, developmental changes, role inflammatory infectious diseases. We also attempted evaluate untapped therapeutic potentials...
Purpose: Cataract is a leading cause of visual impairment globally. This study explored medical, behavioral, and socioeconomic factors associated with cataract development in rural community Imo State, Nigeria. Methods: A case-control was done on 61 patients above 40 years old from medical outreach program to determine the presence its risk factors. Results: Of 54 complete records, 52% had cataracts (while 48% no cataracts). There were significant differences co-morbidities such as ocular...
Hypoxic ischemic encephalopathy (HIE) secondary to perinatal asphyxia leads long-term visual disabilities. Dilated retinal exams in human newborns with HIE is an emerging diagnostic tool, but phenotypes of hypoxia ischemia (HI) related vascular injury are unclear. 7,8-Dihydroxyflavone (7,8-DHF) a TrkB agonist protective effects on HI-related brain damage. We studied vessels mouse model neonatal and the efficacy 7,8-DHF ameliorating injury. C57BL6/J mice at post-natal day (P) 9 received...
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