Coronavirus Disease 2019 (COVID-19) is a newly emerging infectious disease caused by novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). After its first occurrence in Wuhan of China from December 2019, COVID-19 rapidly spread around the world. According to World Health Organization statement on 13 March 2020, there had been over 132 500 confirmed cases globally. Nevertheless, case reports children are rare, which results lack evidence for preventing and...

To observe the effect of corticosteroids in treatment children with refractory Mycoplasma pneumoniae pneumonia (RMPP) under different doses, to summarize clinical features treated glucocorticoid pulse therapy.

In children, refractory Mycoplasma pneumoniae pneumonia (RMPP) may result in severe complications and high medical costs. There is research on a simple easy-to-use nomogram for early prediction timely treatment of RMPP.From December 2018 to June 2021, we retrospectively reviewed records 299 children with (MPP) hospitalized Tianjin Children's Hospital. According their clinical manifestations, patients were divided into the RMPP group general (GMPP) group. The laboratory indicators,...

Early identification of plastic bronchitis (PB) is great importance and may aid in delivering appropriate treatment. This study aimed to develop validate a nomogram for predicting PB patients with refractory Mycoplasma pneumoniae pneumonia (RMPP).A total 547 consecutive children RMPP who underwent fiberoptic bronchoscopy (FOB) intervention from January 2016 June 2021 were enrolled this study. Subsequently, 374 (PB: 137, without PB: 237) December 2019 assigned the development dataset...

<title>Abstract</title> Background The early prediction of pulmonary necrosis in children with severe pneumonia improves patient prognosis and prevents complications. aim this study was to establish a linear model for predicting necrotizing (NP) caused by <italic>Mycoplasma pneumoniae</italic> (MP) infection investigate the risk factors lung refractory (RMPP). Methods A total 536 RMPP were enrolled, including 95 NP 441 nonnecrotizing (NNP). built on 375 cases validated 161 cases, which...

This study is to evaluate the usefulness of pathogen detection using metagenomic next-generation sequencing (mNGS) on bronchoalveolar lavage fluid (BALF) specimens from children with community-acquired pneumonia (CAP). We retrospectively collected BALF 121 CAP at Tianjin Children's Hospital February 2021 December 2021. The diagnostic performances mNGS and conventional tests (CT) (culture targeted polymerase chain reaction tests) were compared, composite diagnosis as reference standard....

Rapid and accurate identification of pathogens is very important for the treatment Severe community-acquired pneumonia (SCAP) in children. Metagenomic Next-generation sequencing (mNGS) has been applied detection pathogenic bacteria recent years, while overall evaluation application SCAP children lacking.In our study, 84 cases were enrolled. Bronchoalveolar lavage fluid (BALF) samples analysed using mNGS; sputum, blood, BALF conventional technology (CT).Among children, 41 boys, 43 girls, with...

To analyze the clinical characteristics of Mycoplasma pneumoniae pneumonia with hypoxia in children, and identify associated risk factors MPP.A retrospective case-control study was performed on 345 children (MPP) admitted to our hospital wards from January 2017 June 2019. They were divided into three groups, namely MPP hypoxia, refractory (RMPP), general (GMPP). The features, laboratory findings, imaging, management collected compared groups.The patients (n = 69) had longer disease duration,...

Mycoplasma pneumoniae pneumonia (MPP) is a prevalent disease in community-acquired among children. However, addition to respiratory manifestations, it may also develop extra-pulmonary complications. Embolism one of the uncommon extra-respiratory manifestations prone severe sequelae and even death. This study aims analyze clinical features MPP with embolism children, explore associated risk factors patients.A retrospective case-control analysis was performed on 48 children admitted our...

Acute myelogenous leukemia (AML) is a common pediatric malignancy in children younger than 15 years old. Although the overall survival (OS) has been improved recent years, mechanisms of AML remain largely unknown. Hence, purpose this study to explore differentially methylated genes and investigate underlying mechanism initiation progression based on bioinformatic analysis.Methylation array data gene expression were obtained from TARGET Data Matrix. The consensus clustering analysis was...

A multicenter study was performed to evaluate the value of testing gastric aspirate (GA) with Xpert MTB/RIF Ultra assay (Ultra) for childhood tuberculosis (TB) detection in China. In total, 129 children active TB and 173 without were enrolled. The sensitivity bacteriologically confirmed probable cases 87.5% (42/48) 44.4% (36/81), respectively. specificity high (99.4%, 172/173). When Ultra, culture, acid-fast bacilli outcomes integrated as a composite reference standard, percentage definite...

In this paper, we integrate the blueonline-updating Gaussian Process (GP) models into Model Predictive Control (MPC) design of nonlinear systems with time-varying dynamics to obtain a more accurate data-based prediction state, and relaxed constraints. Specifically, considering that GP inferred from Bayesian framework provides both predictive value estimation uncertainties, mechanism updating model stability constraint based on Lyapunov techniques is designed according online mismatch between...

Abstract Background This study investigated clinical and laboratory characteristics of human bocavirus type 1 (HBoV1)‐plastic bronchiolitis (PB), Mycoplasma pneumoniae (MP)‐associated plastic bronchitis (PB) MP‐NPB in children, highlighting inflammation, coagulation, bronchoscopic needs. Methods Data on preschool children with PB during HBoV1 or MP infection were collected, comparing MP‐PB to severe pneumonia . Result Compared the group, HBoV1‐PB younger had significantly milder symptoms but...

Background: Increasing evidence has revealed that epithelial-mesenchymal transition (EMT) and immunity play key roles in idiopathic pulmonary fibrosis (IPF). However, correlation between EMT immune response the prognostic significance of IPF remains unclear. Methods: Two microarray expression profiling datasets (GSE70866 GSE28221) were downloaded from Gene Expression Omnibus (GEO) database. EMT- immune-related genes identified by gene set variation analysis (GSVA) Estimation STromal Immune...

The Gaussian process model inferred from the Bayesian framework is a powerful data modeling method. It provides not only predictive value but also uncertainty measure for result. In this paper, we combine online-updating GP models with Tube MPC to achieve safety control system of unknown dynamics, and especially use its capability quantification assist in guarantee under certain probability. Tightened constraints used determine center are computed according designed method based on mean...

Fulminant Mycoplasma pneumoniae pneumonia (FMPP) accounts for 0.5-2% of all MPP cases, which is considered as combined with severe complications such hypoxemia, acute respiratory distress syndrome, or failure. It primarily affects young adults no underlying disease. Although some studies have proved the severity FMPP, details about clinical diagnosis and treatment FMPP in children been rarely reported. In this case study, we described three cases who suffered from FMPP. These not only...

Mycoplasma pneumoniae (MP) is a common pathogen of lower respiratory tract infection in children and adolescents. Some patients with MP are self-limiting, while the increase severe or refractory pneumonia (MPP) recent years, there great reports thromboembolism multiple organs, including lung, brain, spleen, peripheral arteries. Cardiac thrombi pulmonary embolism associated have not been reported. The most effective treatment option for cardiac thrombus was surgical resection fear detachment...

Objective: To explore the relevant influencing factors of neonatal respiratory distress syndrome (NRDS) in southern China and provide scientific basis for improving quality life neonates.Methods: A retrospective analysis 320 cases with NRDS neonates admitted from January 2015 to December 2017 a department Maternal Child Health Hospital South was conducted. Three hundred twenty non-NRDS patients same hospital during period were also included as control. The basic characteristics compared risk...

This work explores the design of distributed model predictive control (DMPC) systems using Gaussian process (GP) models to predict nonlinear dynamic behavior for processes with unknown dynamics. Specifically, DMPC is designed and analyzed concerning closed-loop stability performance properties based on Lyapunov techniques. First, GP used in developed updated a manner where each subsystem only considers its physically interacted states except own get sufficiently accurate relatively smaller...

Abstract Background : Analyze the clinical characteristics of Mycoplasma pneumoniae pneumonia with hypoxia in children, and identify related factors MPP. Methods A retrospective case-control study was performed on 345 children (MPP) hospitalized our hospital from January 2017 to June 2019. The features, laboratory data radiological findings were compared between MPP hypoxia, refractory (RMPP) general (GMPP) groups. Results patients (n=69) had a higher incidence extra-pulmonary complications...

This study aimed to investigate the efficacy and safety of CO2 cryotherapy for lymph node fistula tracheobronchial tuberculosis (TBTB) in infants.A retrospective analysis was undertaken on seven patients with who underwent fiberoptic bronchoscopy (FB) interventional therapy respiratory department Tianjin Children's Hospital from July 2012 2020. The efficacy, safety, prognosis intervention treatment TBTB infants were summarized analyzed.Seven included this study. Their ages ranged 6-13...

Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis and related to severity disease. This study aimed develop validate a nomogram for predicting severe in infants young children with RSV infection.

With the rapid increase in number of infections, children with Staphylococcus aureus (S. aureus) infection secondary to Influenza A virus (IAV), appear have a great possibility causing severe complications and illness. Despite some cases research findings regarding death IAV S. aureus, coinfection included, there were few details about successful treatment pleural empyema necrotizing pneumonia caused by methicillin-resistant (MRSA) following IAV. In this case report, we describe clinical...