A5052311517- Ferroptosis and cancer prognosis
- Bladder and Urothelial Cancer Treatments
- Prostate Cancer Treatment and Research
- Cancer, Lipids, and Metabolism
- Urinary and Genital Oncology Studies
- Epigenetics and DNA Methylation
- Chronic Disease Management Strategies
- Prostate Cancer Diagnosis and Treatment
- Medical Research and Treatments
- Traditional Chinese Medicine Studies
- Advanced Chemical Sensor Technologies
- Peroxisome Proliferator-Activated Receptors
- Cardiovascular Health and Risk Factors
- Phytochemicals and Antioxidant Activities
- Renal cell carcinoma treatment
- Renal and related cancers
- Medical Research and Practices
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Cancer Immunotherapy and Biomarkers
- Economic and Financial Impacts of Cancer
- Phagocytosis and Immune Regulation
- Recycling and utilization of industrial and municipal waste in materials production
- Botanical Research and Applications
- Waste Management and Recycling
- Diabetes Management and Education
Nanchang University
2012-2025
First Affiliated Hospital of Nanchang University
2022-2025
First Affiliated Hospital of Jiangxi Medical College
2024
Institute for Clinical Evaluative Sciences
2016
Women's College Hospital
2016
University of Alberta
2016
Songjiang District Central Hospital
2012
Drexel University
2009
Project Management Institute
2004
Abstract Background This study aimed to investigate the relationship between serum testosterone levels and risk of congestive heart failure (CHF) in adult males. Previous research has suggested a potential link cardiovascular health, but findings have been inconclusive. Methods was cross-sectional, data were obtained from 2011–2016 cycle National Health Nutrition Examination Survey (NHANES), which included sample 6,841 male participants. Serum measured using standardized assay, CHF status...
Aronia melanocarpa fruit contains a variety of active ingredients, such as phenolic acids, anthocyanins, proanthocyanidins, etc. Relevant in vivo and vitro studies have concluded that it has beneficial effects terms treating dyslipidemia, hypertension, glucose metabolism disorders, This article discusses the nutritional value food processing reviews chemical components pharmacological activities related substances order to summarize characteristics its development prospects. The process...
Coal fly ash has a strong alkaline buffering capacity which may render heavy metals in sewage sludge unavailable and the aim of this project is to study potential coal as co-composting material for by evaluating its effect on microbial decomposition sludge. Lagoon at 0, 2.5, 5, 10, 20, 50% w/w were mixed with dewatered incubated 25°C 3 months. Carbon dioxide evolution all treatments followed same trend except amendment both residues. When compared control (sludge only), higher levels...
Background Plasma membrane tension-related genes (MTRGs) are known to play a crucial role in tumor progression by influencing cell migration and adhesion. However, their specific mechanisms bladder cancer (BLCA) remain unclear. Methods Transcriptomic, clinical mutation data from BLCA patients were collected The Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases. Clusters associated with MTRGs identified consensus unsupervised cluster analysis. of different clusters analyzed...
Objective: The aim of this study was to develop and validate predictive models for perineural invasion (PNI) in gastric cancer (GC) using clinical factors radiomics features derived from contrast-enhanced computed tomography (CE-CT) scans compare the performance these models. Methods: This included 205 GC patients, who were randomly divided into a training set (n=143) validation (n=62) 7:3 ratio. Optimal selected least absolute shrinkage selection operator (LASSO) algorithm. A model...
To characterize comorbid chronic conditions, describe health services use, and estimate care costs among community-dwelling older adults with prior stroke.This is a retrospective cohort study using administrative data from Ontario, Canada. We identified all individuals aged 66 over on April 1, 2008 (baseline), who had experienced stroke at least 6 months prior. estimated the prevalence of 14 conditions baseline; we captured physician visits, emergency department hospital admissions, home...
Background Both lactylation and m6A modification have important implications for the development of clear cell renal carcinoma (ccRCC), we aimed to use crosstalk genes both reveal prognostic immunological features ccRCC. Methods Our first step was look lactylation-related that differed between normal tumor tissues, then by correlation analysis, found associated with M6A. Following that, ccRCC subtypes will be identified risk models constructed compare prognosis microenvironment among...
Purpose: Currently, there is limited knowledge about platinum resistance-related long non-coding RNAs (lncRNAs) in bladder cancer. We aim to identify lncRNAs and construct a risk model for accurate prognostic prediction of Methods: Transcriptomic clinical data were extracted from The Cancer Genome Atlas (TCGA) database, genes obtained HGSOC-Platinum. by the Spearman correlation analysis. Then, we constructed score through Cox regression analysis LASSO algorithm. was verified analyzing median...
Predicting the accurate preoperative staging of bladder cancer (BLCA), which markedly affects treatment decisions and patient outcomes, using traditional clinical parameters is challenging. Nevertheless, emerging studies in radiomics, especially machine learning-based computed tomography (CT) image-based hold promise improving stage prediction accuracy various tumors. However, comparative performance utility models for BLCA are under investigation.
Bladder cancer (BLCA) is a prevalent malignancy. Dysregulated propionate metabolism, key factor, suggests potential target for treating metastatic cancer. However, complete understanding of the link between metabolism-related genes (PMRGs) and bladder lacking. From Cancer Genome Atlas (TCGA) Gene Expression Omnibus (GEO) databases, we gathered BLCA patient data, which was classified into distinct subgroups using non-negative matrix factorization (NMF). Survival pathway analyses were...
To construct and validate unfavorable pathology (UFP) prediction models for patients with the first diagnosis of bladder cancer (initial BLCA) to compare comprehensive predictive performance these models.A total 105 initial BLCA were included randomly enrolled into training testing cohorts in a 7:3 ratio. The clinical model was constructed using independent UFP-risk factors determined by multivariate logistic regression (LR) analysis cohort. Radiomics features extracted from manually...
To identify the molecular subtypes and develop a scoring system for tumor immune microenvironment (TIME) prognostic features of bladder cancer (BLCA) based on platinum-resistance-related (PRR) genes analysis while identifying P4HB as potential therapeutic target.In this study, we analyzed gene expression data clinical information 594 BLCA samples. We used unsupervised clustering to levels PRR genes. Functional pathway enrichment analyses were performed understand biological activities these...
<title>Abstract</title> Bladder cancer (BLCA) is ranked among the main causes of mortality in male patients, and research into targeted therapies guided by its genomics molecular biology has been a prominent focus BLCA studies. Fatty acid transporter protein 2 (FATP2/SLC27A2), member FATPs/SLC27As family,is key contributor to progression cancers such as hepatocellular carcinomas melanomas.However,its role remains poorly understand. This study delved function FATP2 through succession...
Abstract Prostate cancer bone metastasis is a predominant cause of death for prostate (PCa) patients. However, the underlying mechanisms are poorly understood. Here, we report that high levels RNF41 associated with metastatic human cancer. silencing inhibits cell growth, migration and invasion in vitro vivo. Mechanistically, identify induces K27- K63-linked noncanonical polyubiquitination MYO1C to enhance its stability induce actin remodeling, which promotes PCa metastasis. was significantly...
Abstract Purpose Abnormal spermatozoa significantly impact reproductive health, affecting fertility rates, potentially prolonging conception time, and increasing the risk of miscarriages. This study employs Mendelian randomization to explore their potential link with immune cells, aiming reveal causal association wider implications for health. Methods We conducted forward reverse analyses connection between 731 cell signatures abnormal spermatozoa. Using publicly available genetic data, we...
Metastatic prostate cancer (mPCa) complicates treatment due to its unpredictable progression. Current prognostic tools often lack precision. This study aimed develop an effective tool predict overall survival (OS) in mPCa patients undergoing radiotherapy, thereby addressing the clinical need for personalized decisions.